The invention provides a composition of matter of the formula (I): V—L—R where V is an organic group having binding affinity for an angiotensin II receptor site, L is a linker moiety or a bond, and R is a moiety detectable in in vivo imaging of a human or animal body, with the provisos that where V is angiotensin or a peptidic angiotensin derivative or analog then V—L—R is other than a non-metal radionuclide substituted peptide (e.g.
125
I substituted angiotensin II) and L—V is other than simply a peptide with a chelating agent amide bonded to a side chain thereof. This composition of matter may be used to image cardiovascular diseases and disorders.
本发明提供一种物质组成式(I)的组合物:V—L—R,其中V是具有与
血管紧张素II受体位点结合亲和力的有机基团,L是连接基团或键,R是在人体或动物体内成像中可检测到的基团,但须注意,当V是
血管紧张素或
血管紧张素衍
生物或类似物时,V—L—R不是非
金属放射性核素替代肽(例如125I替代
血管紧张素II),而L—V不是仅具有与其侧链缀合剂酰胺键合的肽。该物质组合物可用于成像心血管疾病和障碍。