生物素二酸 | 57671-79-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 生物素及其衍生物
• 中文名称: 生物素二酸
• 中文别名: 生物素杂质B
• 英文名称: Diacid
• 英文别名: [3-((3aS)-2-oxo-(3ar,6ac)-hexahydro-thieno[3,4-d]imidazol-4t-yl)-propyl]-malonic acid；Biotin Diacid；2-[3-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]propyl]propanedioic acid
• CAS: 57671-79-1
• 化学式: C₁₁H₁₆N₂O₅S
• 分子量: 288.324
• InChiKey: XWJBVGZSIAZDKJ-FXQIFTODSA-N

物化性质

• 熔点：
  >212°C (dec.)
• 溶解度：
  碱性溶液（微溶）、DMSO（微溶）、甲醇（微溶）

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  141
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  生物素二酸 在 sodium hydroxide 作用下， 反应 0.5h， 生成 D-生物素
  参考文献：
  名称：

  从L（+）-半胱氨酸立体定向的总合成d-生物素。

  摘要：

  DOI：

  10.1021/ja00463a042
• 作为产物：
  描述：

  (3aS)-3t-azido-(3ar,7ac)-hexahydro-thieno[3,2-b]pyridin-5-one 在 palladium on activated charcoal 锂硼氢 、 氢溴酸 、 氢气 作用下， 以 四氢呋喃 、 乙醇 、 溶剂黄146 为溶剂， 25.0~100.0 ℃ 、310.27 kPa 条件下， 反应 20.0h， 生成 生物素二酸
  参考文献：
  名称：

  从L（+）-半胱氨酸立体定向的总合成d-生物素。

  摘要：

  DOI：

  10.1021/ja00463a042

文献信息

• Water soluble multi-biotin-containing compounds
  申请人：Wilbur Scott D.

  公开号：US20060228325A1

  公开（公告）日：2006-10-12

  Water-soluble discrete multi-biotin-containing compounds with at least three (3) biotin moieties are disclosed. The water-soluble biotin-containing compounds may additionally comprise one or more moieties that confer resistance to cleavage by biotinidase or that is cleavable in vitro or in vivo. The discrete multi-biotin-containing compounds may include a reactive moiety that provides a site for reaction with yet another moiety, such as a targeting, diagnostic or therapeutic functional moiety. Biotinylation reagents comprising water-soluble linker moieties are also disclosed and may additionally comprise a biotinidase protective group. Methods for amplifying the number of sites for binding biotin-binding proteins at a selected target using multi-biotin compounds also are disclosed.

  可溶于水的离散多生物素含有化合物，至少含有三个（3）生物素基团。这些可溶于水的生物素含有化合物可能还包括一个或多个使其对生物素酶的裂解具有抗性的基团，或者在体外或体内可被裂解的基团。这些离散的多生物素含有化合物可能包括一个反应性基团，提供与另一个基团（如靶向、诊断或治疗功能基团）反应的位点。还公开了包含可溶于水的连接基团的生物素化试剂，可能还包括生物素酶保护基团。还公开了使用多生物素化合物扩增在选定靶点上结合生物素结合蛋白的位点数量的方法。
• Polymerization method for the synthesis of polypeptide imaging agents
  申请人：Grimmond James Brian

  公开号：US20060104908A1

  公开（公告）日：2006-05-18

  A method for synthesizing extended poly(amino acids) conjugated to imaging agents, such as DTPA, is disclosed. The amino acid is initially conjugated to the imaging agent at the monomer stage, followed by formation of the corresponding N-carboxyanhydride. The method utilizes catalyzed ring opening polymerization of the N-carboxyanhydride of the amino acid-imaging agent monomer allowing the formation of a poly(amino acid) backbone having 100% imaging agent conjugation if desired. However, the present method also permits the degree of conjugation to be controlled by copolymerizing the N-carboxyanhydride of the amino acid-imaging agent monomer with one or more unconjugated monomers, i.e. N-carboxyanhydrides of the same or of other amino acids. Various imaging agents may be employed, and new hybrid random, block, and mixed copolymers may be prepared.

  揭示了一种用于合成与成像剂（如DTPA）共轭的扩展型聚（氨基酸）的方法。氨基酸最初在单体阶段与成像剂共轭，然后形成相应的N-羧酸酐。该方法利用氨基酸-成像剂单体的N-羧酸酐的催化环开聚合，允许形成具有100%成像剂共轭的聚（氨基酸）骨架，如果需要的话。然而，该方法还允许通过与一个或多个未共轭单体共聚合，即氨基酸-成像剂单体的N-羧酸酐与相同或其他氨基酸的N-羧酸酐共聚合，来控制共轭程度。可以使用各种成像剂，并可以制备新的混合随机、块状和混合共聚物。
• [EN] PHOTOPROXIMITY PROFILING OF PROTEIN-PROTEIN INTERACTIONS IN CELLS<br/>[FR] PROFILAGE DE PHOTOPROXIMITÉ D'INTERACTIONS PROTÉINE-PROTÉINE DANS DES CELLULES
  申请人：UNIV CHICAGO

  公开号：WO2021055960A1

  公开（公告）日：2021-03-25

  Photoactive probes and probe systems for detecting biological interactions are described. The photoactive probes include probes that combine both photocleavable and photoreactive moieties. The photoactive probe systems can include a first probe comprising a photocatalytic group and a second probe comprising a group that can act as a substrate for the reaction catalyzed by the photocatalytic group. The probes and probe systems can also include groups that can specifically bind to a binding partner on a biological entity of interest and a detectable group or a precursor thereof. The probes and probe systems can detect spatiotemporal interactions of proteins or cells. In some embodiments, the interactions can be detected in live cells. Also described are methods of detecting the biological interactions.

  描述了用于检测生物相互作用的光活性探针和探针系统。光活性探针包括同时结合光解和光反应基团的探针。光活性探针系统可以包括第一探针，其中包括光催化基团，以及第二探针，其中包括可作为光催化基团催化反应底物的基团。探针和探针系统还可以包括能够特异性结合到感兴趣生物实体上的结合伙伴的基团，以及可检测的基团或其前体。这些探针和探针系统可以检测蛋白质或细胞的时空相互作用。在某些实施方式中，这些相互作用可以在活细胞中检测到。还描述了检测生物相互作用的方法。
• MODIFIED BIOTIN-BINDING PROTEINS FOR IMMOBILIZATION
  申请人：Pacific Biosciences of California, Inc.

  公开号：US20190249237A1

  公开（公告）日：2019-08-15

  Compositions comprising covalently modified and mutated biotin-binding proteins, particularly biotin-binding proteins having a negative charge at physiological pH, are provided. Methods of producing such proteins are also provided, as are methods of immobilizing, sequencing, and making nucleic acids employing such proteins.

  提供了包含共价修饰和突变生物素结合蛋白的组合物，特别是在生理pH下具有负电荷的生物素结合蛋白。 还提供了生产这种蛋白质的方法，以及使用这种蛋白质固定、测序和制备核酸的方法。
• [EN] DIAZINYL AMINO ACRIDINES AND MEDICAL USES THEREOF<br/>[FR] DIAZINYL AMINO ACRIDINES ET LEURS UTILISATIONS MÉDICALES
  申请人：LARSSON LARS GUNNAR OLOF

  公开号：WO2019145375A1

  公开（公告）日：2019-08-01

  There is provided herein compounds of formula (I) and pharmaceutically-acceptable salts and/or detectably-labelled derivatives thereof, wherein R1 to R3, X, Y, n and m have meanings as provided in the description, together with formulations and products comprising the same. There is also provided the use of such compounds, formulations and products in the treatment of cancers characterised by increased MYC activity.

  本文提供了式（I）的化合物和药用盐和/或可检测标记衍生物，其中R1到R3、X、Y、n和m的含义如描述中所提供，以及包含这些化合物的配方和产品。还提供了这些化合物、配方和产品在治疗因MYC活性增加而特征化的癌症中的用途。