Methyl (R)-2-hydroxy-3-phenylbutyrate | 1248973-18-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Methyl (R)-2-hydroxy-3-phenylbutyrate
• 英文别名: 2-Hydroxy-3-phenyl-butyric acid methyl ester；Methyl 2-hydroxy-3-phenylbutanoate
• CAS: 1248973-18-3
• 化学式: C₁₁H₁₄O₃
• 分子量: 194.23
• InChiKey: CIBFKVUVTTWVKH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Methyl (R)-2-hydroxy-3-phenylbutyrate 在 Saccharomyces cerevisiae 、 jones reagent 、 四丁基氟化铵 、 蔗糖 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 、 丙酮 为溶剂， 反应 105.5h， 生成 (2R,3R)-2-Hydroxy-3-phenylbutyric acid methyl ester
  参考文献：
  名称：

  Akita, Hiroyuki; Furuichi, Akiya; Koshiji, Hiroko, Chemical and pharmaceutical bulletin, 1984, vol. 32, # 4, p. 1342 - 1348

  摘要：

  DOI：
• 作为产物：
  描述：

  3-methyl-3-phenyl-oxiranecarboxylic acid methyl ester 在 palladium on activated charcoal 甲酸铵 作用下， 以 甲醇 为溶剂， 反应 3.0h， 以95%的产率得到Methyl (R)-2-hydroxy-3-phenylbutyrate
  参考文献：
  名称：

  Pd 催化的环氧化物和缩水甘油酯的区域特异性还原开环

  摘要：

  摘要 环氧化物的区域特异性开环是通过以甲酸铵为氢源的钯催化转移氢解实现的。

  DOI：

  10.1080/00397919508011782

文献信息

• POSITIVE-TYPE PHOTOSENSITIVE RESIN COMPOSITION, METHOD FOR PRODUCING SEMICONDUCTOR DEVICE INCLUDING CURED FILM USING THE SAME
  申请人：TORAY INDUSTRIES, INC.

  公开号：US20150212412A1

  公开（公告）日：2015-07-30

  The present invention provides a positive-type photosensitive resin composition capable of obtaining a cured film which exhibits low warpage, and is also excellent in high sensitivity and high resolution during firing at a lower temperature of 250° C. or lower. Disclosed is a positive-type photosensitive resin composition including (a) a polyimide resin including a structural unit represented by the general formula (1) and a structural unit represented by the general formula (2), and (b) a quinonediazide compound, wherein the polyimide resin including a structural unit represented by the general formula (1) and a structural unit represented by the general formula (2) has an imidation ratio of 85% or more, and also a ratio of the structural unit represented by the general formula (1) to the structural unit represented by the general formula (2) is within a range of 30:70 to 90:10, in which X 1 in the general formula (1) represents a tetracarboxylic acid residue including 1 to 4 aromatic rings, and Y 1 represents an aromatic diamine residue including 1 to 4 aromatic rings, and in which X 2 in the general formula (2) represents a tetracarboxylic acid residue including 1 to 4 aromatic rings, and Y 2 represents a diamine residue including at least two or more alkylene glycol units in the main chain.

  本发明提供了一种正型光敏树脂组合物，能够获得低翘曲性的固化膜，并且在低于250℃的较低温度下烧结时具有高灵敏度和高分辨率。本发明揭示了一种正型光敏树脂组合物，包括（a）聚酰亚胺树脂，包括由一般式（1）表示的结构单元和由一般式（2）表示的结构单元，以及（b）喹喔啉二酮化合物。其中，聚酰亚胺树脂包括由一般式（1）表示的结构单元和由一般式（2）表示的结构单元，其酰亚胺化比例为85％或更高，并且一般式（1）表示的结构单元与一般式（2）表示的结构单元的比例在30:70至90:10的范围内，其中，一般式（1）中的X1表示包括1至4个芳香环的四羧酸残基，Y1表示包括1至4个芳香环的芳香二胺残基，一般式（2）中的X2表示包括1至4个芳香环的四羧酸残基，Y2表示主链中包含至少两个或更多的烷基二醇单元的二胺残基。
• FXIA INHIBITORS AND PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF
  申请人：Shenzhen Salubris Pharmaceuticals Co. Ltd

  公开号：EP4036087A1

  公开（公告）日：2022-08-03

  Provided in the present invention is a series of selective Factor XIa (FXIa) inhibitors, relating to the technical field of chemical drugs. The present invention also relates to pharmaceutical compositions containing said compounds and a use of said compounds in drugs for the treatment of diseases such as thromboembolism.

  本发明提供了一系列选择性因子XIa（FXIa）抑制剂，涉及化学药物技术领域。本发明还涉及包含所述化合物的药物组合物以及利用所述化合物制备用于治疗血栓栓塞性疾病等疾病的药物。
• POSITIVE PHOTOSENSITIVE RESIN COMPOSITION, AND METHOD FOR PRODUCING SEMICONDUCTOR DEVICE CONTAINING A CURED FILM USING SAID COMPOSITION
  申请人：Toray Industries, Inc.

  公开号：EP2902847A1

  公开（公告）日：2015-08-05

  The present invention provides a positive-type photosensitive resin composition capable of obtaining a cured film which exhibits low warpage, and is also excellent in high sensitivity and high resolution during firing at a lower temperature of 250°C or lower. Disclosed is a positive-type photosensitive resin composition including (a) a polyimide resin including a structural unit represented by the general formula (1) and a structural unit represented by the general formula (2), and (b) a quinonediazide compound, wherein the polyimide resin including a structural unit represented by the general formula (1) and a structural unit represented by the general formula (2) has an imidation ratio of 85% or more, and also a ratio of the structural unit represented by the general formula (1) to the structural unit represented by the general formula (2) is within a range of 30:70 to 90:10, in which X1 in the general formula (1) represents a tetracarboxylic acid residue including 1 to 4 aromatic rings, and Y1 represents an aromatic diamine residue including 1 to 4 aromatic rings, and in which X2 in the general formula (2) represents a tetracarboxylic acid residue including 1 to 4 aromatic rings, and Y2 represents a diamine residue including at least two or more alkylene glycol units in the main chain.

  本发明提供了一种正型感光树脂组合物，该组合物能够获得低翘曲的固化膜，并且在 250°C 或更低温度下烧制时具有优异的高灵敏度和高分辨率。本发明公开了一种正型感光树脂组合物，包括 (a) 聚酰亚胺树脂（包括通式 (1) 所代表的结构单元和通式 (2) 所代表的结构单元）和 (b) 喹螨酯化合物、其中，包括通式(1)代表的结构单元和通式(2)代表的结构单元的聚酰亚胺树脂的亚胺化率为85%或以上，通式(1)代表的结构单元与通式(2)代表的结构单元的比例范围为30：通式（1）中的 X1 代表包括 1 至 4 个芳香环的四羧酸残基，Y1 代表包括 1 至 4 个芳香环的芳香二胺残基，通式（2）中的 X2 代表包括 1 至 4 个芳香环的四羧酸残基，Y2 代表主链中至少包括两个或更多亚烷基二醇单元的二胺残基。
• US9454078B2
  申请人：——

  公开号：US9454078B2

  公开（公告）日：2016-09-27
• Pd-Catalysed Regiospecific Reductive Ring Opening of Epoxides and Glycidic Esters
  作者：Jos P. Varghese、Arumugam Sudalai、Suresh Iyer

  DOI：10.1080/00397919508011782

  日期：1995.8

  Abstract The regiospecific ring opening of epoxides was achieved by Pd-catalysed transfer hydrogenolysis using ammonium formate as hydrogen source.

  摘要 环氧化物的区域特异性开环是通过以甲酸铵为氢源的钯催化转移氢解实现的。