1-(5-(3-chlorophenyl)-4,5-dihydro-3-phenylpyrazol-1-yl)-2-(quinolin-8-yloxy)ethanone | 1252936-00-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-(5-(3-chlorophenyl)-4,5-dihydro-3-phenylpyrazol-1-yl)-2-(quinolin-8-yloxy)ethanone
• 英文别名: 1-[3-(3-Chlorophenyl)-5-phenyl-3,4-dihydropyrazol-2-yl]-2-quinolin-8-yloxyethanone
• CAS: 1252936-00-7
• 化学式: C₂₆H₂₀ClN₃O₂
• 分子量: 441.917
• InChiKey: XAUXHGOSSYRHNS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  32
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  54.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-(喹啉-8-基氧基)乙酰肼 、 (2E)-3-(3-chlorophenyl)-1-phenylprop-2-en-1-one 在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 以16%的产率得到1-(5-(3-chlorophenyl)-4,5-dihydro-3-phenylpyrazol-1-yl)-2-(quinolin-8-yloxy)ethanone
  参考文献：
  名称：

  Synthesis, characterization, antiamoebic activity and cytotoxicity of novel series of pyrazoline derivatives bearing quinoline tail

  摘要：

  The cyclization of chalcones (1a-1j) with 2-(quinolin-8-yloxy) acetohydrazide (2) under basic condition led to the formation of new compounds. pyrazoline derivatives (3a-3j) In vitro antiamoebic activity was performed against HM1: IMSS strain of Entamoeba histolytica The results showed that the compounds 3d, 3g, 3h, and 3j exhibited promising antiamoebic activity (IC(50) = 0 05 mu M, 0 31 mu M, 006 mu M, 0 29 mu M) respectively than the standard drug metronidazole (IC(50) = 1 84 mu M). The toxicological studies of these compounds on human breast cancer MCF-7 cell line showed that all the compounds 3d, 3g, 3h, 3j and metronidazole were nontoxic at the concentration range of 1.56-50 mu M. (C) 2010 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2010.07.028

文献信息

• Synthesis, characterization, antiamoebic activity and cytotoxicity of novel series of pyrazoline derivatives bearing quinoline tail
  作者：Faisal Hayat、Attar Salahuddin、Sadiq Umar、Amir Azam

  DOI：10.1016/j.ejmech.2010.07.028

  日期：2010.10

  The cyclization of chalcones (1a-1j) with 2-(quinolin-8-yloxy) acetohydrazide (2) under basic condition led to the formation of new compounds. pyrazoline derivatives (3a-3j) In vitro antiamoebic activity was performed against HM1: IMSS strain of Entamoeba histolytica The results showed that the compounds 3d, 3g, 3h, and 3j exhibited promising antiamoebic activity (IC(50) = 0 05 mu M, 0 31 mu M, 006 mu M, 0 29 mu M) respectively than the standard drug metronidazole (IC(50) = 1 84 mu M). The toxicological studies of these compounds on human breast cancer MCF-7 cell line showed that all the compounds 3d, 3g, 3h, 3j and metronidazole were nontoxic at the concentration range of 1.56-50 mu M. (C) 2010 Elsevier Masson SAS. All rights reserved.