β-D-Man p-(1->2)-α-D-Man | 50271-58-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: β-D-Man p-(1->2)-α-D-Man
• 英文别名: β-D-mannopyranosyl-(1->2)-D-mannopyranoside；Manβ1-2Manα；2-O-beta-D-mannopyranosyl-alpha-D-mannopyranose；(2S,3S,4S,5S,6R)-6-(hydroxymethyl)-3-[(2S,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxane-2,4,5-triol
• CAS: 50271-58-4
• 化学式: C₁₂H₂₂O₁₁
• 分子量: 342.3
• InChiKey: HIWPGCMGAMJNRG-ONPLHCRPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.2
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  190
• 氢给体数：
  8
• 氢受体数：
  11

反应信息

• 作为产物：
  描述：

  benzyl 3-O-benzyl-4,6-O-benzylidene-β-D-mannopyranosyl-(1->2)-3-O-benzyl-4,6-O-benzylidene-α-D-mannopyranoside 在 palladium on activated charcoal 、 氢气 作用下， 以 甲醇 、 水 为溶剂， 20.0 ℃ 、345.01 kPa 条件下， 反应 16.0h， 生成 、 β-D-Man p-(1->2)-β-D-Man 、 β-D-Man p-(1->2)-α-D-Man
  参考文献：
  名称：

  β-(1→2)-连接寡甘露糖苷的合成

  摘要：

  β-(1→2)-连接的寡甘露糖苷构成了一类重要的碳水化合物结构，位于几种念珠菌属的细胞表面，包括白色念珠菌。由于这些化合物的免疫刺激特性，它们合成的放大是相关的。在本文中，β-(1→2)-连接的寡甘露糖苷的高度立体选择性合成是通过进一步开发和修改文献中先前描述的方法来进行的。除了合成完全脱保护的 β-(1→2)-连接的甘露二糖和甘露三糖之外，还介绍了对寡糖核心的一些初步修饰，从而产生了具有生物潜力的紧密类似物。完全脱保护的产品形成了筛选白色念珠菌的潜在目标，也可能导致疫苗开发的新模型结构。

  DOI：

  10.1002/ejoc.200801024

文献信息

• METHOD OF MAKING AND USING FLUORESCENT-TAGGED NANOPARTICLES AND MICROARRAYS
  申请人：Yan Mingdi

  公开号：US20130252843A1

  公开（公告）日：2013-09-26

  Disclosed embodiments concern differentiating and classifying one or more targets using a perhalophenylazide-derived nanoparticle probe, or multiple such probes. Particular embodiments concern using statistical analysis to produce score plots illustrating the level of differentiation and/or classification. Also disclosed are methods for making perhalophenylazide-derived nanoparticle probes, individually or by using a microarray technique. Particular embodiments concern methods for using the per halophenylazide-derived nanoparticle probes to diagnose, detect, and/or treat a disease. Kits comprising the perhalophenylazide-derived nanoparticle probes are also disclosed.

  公开实施例涉及使用经过卤代苯偶氮苯衍生的纳米颗粒探针或多个这样的探针，区分和分类一个或多个目标。特定实施例涉及使用统计分析来产生得分图，以说明区分和/或分类的水平。还公开了制备经过卤代苯偶氮苯衍生的纳米颗粒探针的方法，可以单独使用或使用微阵列技术。特定实施例涉及使用经过卤代苯偶氮苯衍生的纳米颗粒探针来诊断、检测和/或治疗疾病的方法。还公开了包含经过卤代苯偶氮苯衍生的纳米颗粒探针的试剂盒。
• Mannobiose derivatives
  申请人：MEITO SANGYO CO., LTD.

  公开号：EP0285178A2

  公开（公告）日：1988-10-05

  Novel mannobiose derivative represented by the general formula [I]: wherein groups of R₁ to R₅ each represents -OH, -OR₆, -NHR₆, (R₆ represents an acyl group) or a group represented by the following formula (a), (b), (c), (d) or (e), provided that one of R₁ to R₅ represents -OR₆ or -NHR₆, one of the other 4 groups of R₁ to R₅ represents one of the groups represented by the formulae (a) to (e), and the remaining 3 groups of R₁ to R₅ represent -OH: wherein represents α or β bond are provided by the invention. These compounds give liposomes a specific affinity for Kupffer cells of liver, and can be produced industrially.

  通式[I]代表的新型甘露寡糖衍生物： 其中R₁至R₅的基团各自代表-OH、-OR₆、-NHR₆、（R₆代表酰基）或下式(a)、(b)、(c)、(d)或(e)所代表的基团、条件是 R₁ 至 R₅ 中的一个代表-OR₆ 或-NHR₆，R₁ 至 R₅ 的另外 4 个基团中的一个代表式 (a) 至 (e) 所代表的基团之一，R₁ 至 R₅ 的其余 3 个基团代表-OH： 其中代表 α 或 β 键的基团由本发明提供。 这些化合物使脂质体对肝脏的 Kupffer 细胞具有特异性亲和力，并且可以工业化生产。
• Label free biosensors, gram-negative bacteria detection, and real-time and end point determination of antibiotic effects
  申请人：Oakland University

  公开号：US10287616B2

  公开（公告）日：2019-05-14

  Real-time and end point determination of antibiotic effects are disclosed herein. In one example, a surface of a label free biosensor is exposed to a sample including a gram-negative bacteria. A frequency and/or a current of the biosensor is then allowed to reach a constant value. The surface of the biosensor is then exposed to an antibiotic. Using the biosensor, i) a frequency change versus time and a damping resistance versus time, or ii) a current versus voltage or the current versus time at a fixed potential, or iii) both i and ii are then measured. The frequency change versus time and the damping resistance versus time and/or the current versus voltage or the current versus time are correlated to determine an effect of the antibiotic on the gram-negative bacteria. Examples of the label free biosensors and methods for detecting gram-negative bacteria using the label free biosensors are also disclosed.

  本文公开了抗生素效果的实时和终点测定。在一个例子中，无标记生物传感器的表面暴露于包括革兰氏阴性细菌在内的样本中。然后让生物传感器的频率和/或电流达到恒定值。然后将生物传感器的表面暴露在抗生素中。然后使用该生物传感器测量 i) 频率变化与时间的关系和阻尼电阻与时间的关系，或 ii) 电流与电压的关系或固定电位下电流与时间的关系，或 iii) i 和 ii 的关系。将频率变化与时间、阻尼电阻与时间和/或电流与电压或电流与时间相关联，以确定抗生素对革兰氏阴性细菌的影响。此外，还公开了无标记生物传感器的实例以及使用无标记生物传感器检测革兰氏阴性细菌的方法。
• Preparing carbohydrate microarrays and conjugated nanoparticles
  申请人：Zhou Xichun

  公开号：US20080220988A1

  公开（公告）日：2008-09-11

  The present invention is directed to carbohydrate microarray and conjugated nanoparticles methods of making the same.
• LABEL FREE BIOSENSORS, GRAM-NEGATIVE BACTERIA DETECTION, AND REAL-TIME AND END POINT DETERMINATION OF ANTIBIOTIC EFFECTS
  申请人：Oakland University

  公开号：US20160355866A1

  公开（公告）日：2016-12-08

  Real-time and end point determination of antibiotic effects are disclosed herein. In one example, a surface of a label free biosensor is exposed to a sample including a gram-negative bacteria. A frequency and/or a current of the biosensor is then allowed to reach a constant value. The surface of the biosensor is then exposed to an antibiotic. Using the biosensor, i) a frequency change versus time and a damping resistance versus time, or ii) a current versus voltage or the current versus time at a fixed potential, or iii) both i and ii are then measured. The frequency change versus time and the damping resistance versus time and/or the current versus voltage or the current versus time are correlated to determine an effect of the antibiotic on the gram-negative bacteria. Examples of the label free biosensors and methods for detecting gram-negative bacteria using the label free biosensors are also disclosed.