(E)-N-(2-hydroxyethyl)-3-(2-methoxyphenyl)acrylamide | 1312806-93-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: (E)-N-(2-hydroxyethyl)-3-(2-methoxyphenyl)acrylamide
• 英文别名: N-(2-Hydroxyethyl)-2-methoxycinnamamide；(E)-N-(2-hydroxyethyl)-3-(2-methoxyphenyl)prop-2-enamide
• CAS: 1312806-93-1
• 化学式: C₁₂H₁₅NO₃
• mdl: MFCD01736630
• 分子量: 221.256
• InChiKey: RESCTOBKYJIMHJ-VOTSOKGWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  58.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (E)-N-(2-hydroxyethyl)-3-(2-methoxyphenyl)acrylamide 在 三溴化硼 、 水 作用下， 以 二氯甲烷 为溶剂， 反应 4.5h， 以49.7%的产率得到(E)-N-(2-hydroxyethyl)-3-(2-hydroxyphenyl)acrylamide
  参考文献：
  名称：

  Synthesis and antidepressant-like action of N-(2-hydroxyethyl) cinnamamide derivatives in mice

  摘要：

  This study described the chemical synthesis and pharmacological evaluation of a series of N-(2-hydroxyethyl) cinnamamide derivatives. The structures of them were characterized by IR, (1)H-NMR, MS and elemental analysis. Their antidepressant activities were evaluated by the forced swimming test (FST) and tail suspension test (TST). Pharmacological results of these compounds showed that some of them, given orally, significantly reduced the immobility time in the FST and TST, indicating the antidepressant-like action. Among them, compounds N-(2-hydroxyethyl)cinnamamide (1g), (E)-3-(4-hydroxy-3-methoxyphenyl)-N-(2-hydroxyethyl)acrylamide (1i) and (E)-N-(2-hydroxyethyl)-3-(3-hydroxyphenyl)acrylamide (1n), active in the two models, were considered as the most promising compounds in this study.

  DOI：

  10.1007/s00044-010-9470-7
• 作为产物：
  描述：

  反式-2-甲氧基肉桂酸 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 生成 (E)-N-(2-hydroxyethyl)-3-(2-methoxyphenyl)acrylamide
  参考文献：
  名称：

  Synthesis and antidepressant-like action of N-(2-hydroxyethyl) cinnamamide derivatives in mice

  摘要：

  This study described the chemical synthesis and pharmacological evaluation of a series of N-(2-hydroxyethyl) cinnamamide derivatives. The structures of them were characterized by IR, (1)H-NMR, MS and elemental analysis. Their antidepressant activities were evaluated by the forced swimming test (FST) and tail suspension test (TST). Pharmacological results of these compounds showed that some of them, given orally, significantly reduced the immobility time in the FST and TST, indicating the antidepressant-like action. Among them, compounds N-(2-hydroxyethyl)cinnamamide (1g), (E)-3-(4-hydroxy-3-methoxyphenyl)-N-(2-hydroxyethyl)acrylamide (1i) and (E)-N-(2-hydroxyethyl)-3-(3-hydroxyphenyl)acrylamide (1n), active in the two models, were considered as the most promising compounds in this study.

  DOI：

  10.1007/s00044-010-9470-7

文献信息

• QUINONE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF
  申请人：Kelley Mark R.

  公开号：US20100297113A1

  公开（公告）日：2010-11-25

  This application describes quinone derivatives which target the redox site of Ape1/Ref1. Also included in the invention are pharmaceutical formulations containing the derivatives and therapeutic uses of the derivatives.

  这个应用描述了目标为Ape1/Ref1的氧化还原位点的醌衍生物。发明还包括含有这些衍生物的药物制剂和这些衍生物的治疗用途。
• US9089605B2
  申请人：——

  公开号：US9089605B2

  公开（公告）日：2015-07-28