A compound and method for producing an enantiomerically enriched epoxide from an olefin using a chiral ketone and an oxidizing agent is disclosed.
一种化合物及其生产方法被披露,该方法使用手性酮和氧化剂从烯烃生产具有对映体富集的环氧乙烷。
Asymmetric Epoxidation by Chiral Ketones Derived from Carbocyclic Analogues of Fructose
作者:Zhi-Xian Wang、Susie M. Miller、Oren P. Anderson、Yian Shi
DOI:10.1021/jo001343i
日期:2001.1.1
A number of carbocyclic analogues of the fructose-derived ketone 1 have been prepared and investigated for asymmetric epoxidation. The studies show that the oxygen atom of the pyranose ring of 1 has an impact on the catalyst's activity and selectivity. Conformational, electronic, and steric effects are discussed.