7-(4-hydroxyphenyl)-3-methyl-7,10,11,12-tetrahydro-9H-benzo[b][1,7]phenanthrolin-8-one | 1246517-65-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 7-(4-hydroxyphenyl)-3-methyl-7,10,11,12-tetrahydro-9H-benzo[b][1,7]phenanthrolin-8-one
• 英文别名: 7-(4-Hydroxyphenyl)-3-methyl-7,10,11,12-tetra-hydro-9h-benzo[b][1,7]phenanthrolin-8-one；7-(4-hydroxyphenyl)-3-methyl-9,10,11,12-tetrahydro-7H-benzo[b][1,7]phenanthrolin-8-one
• CAS: 1246517-65-6
• 化学式: C₂₃H₂₀N₂O₂
• 分子量: 356.424
• InChiKey: WXXDWSFTDGJVML-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  27
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  62.2
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  5-氨基喹哪啶 、 1,3-环己二酮 、 对羟基苯甲醛 以 正丁醇 为溶剂， 以76%的产率得到7-(4-hydroxyphenyl)-3-methyl-7,10,11,12-tetrahydro-9H-benzo[b][1,7]phenanthrolin-8-one
  参考文献：
  名称：

  Synthesis of methyl-substituted 1,7-phenanthroline derivatives by condensation of 2-methylquinolin-5-amine with aromatic aldehydes and cyclic 1,3-diketones

  摘要：

  Previously unknown 7-aryl(hetaryl)-3-methyl-7,10,11,12-tetrahydro-9H-benzo[b][1,7]phenanthrolin-8-ones and their 10,10-dimethyl-substituted analogs were synthesized by three-component condensation of 2-methylquinolin-5-amine with aromatic aldehydes and cyclic beta-diketones (cyclohexane-1,3-dione and dimedone) in butyl alcohol.

  DOI：

  10.1134/s1070428010070195

文献信息

• Synthesis of methyl-substituted 1,7-phenanthroline derivatives by condensation of 2-methylquinolin-5-amine with aromatic aldehydes and cyclic 1,3-diketones
  作者：N. G. Kozlov、K. N. Gusak

  DOI：10.1134/s1070428010070195

  日期：2010.7

  Previously unknown 7-aryl(hetaryl)-3-methyl-7,10,11,12-tetrahydro-9H-benzo[b][1,7]phenanthrolin-8-ones and their 10,10-dimethyl-substituted analogs were synthesized by three-component condensation of 2-methylquinolin-5-amine with aromatic aldehydes and cyclic beta-diketones (cyclohexane-1,3-dione and dimedone) in butyl alcohol.