1-(4-Mercapto-phenyl)-2-methyl-propan-1-one | 91358-97-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(4-Mercapto-phenyl)-2-methyl-propan-1-one
• 英文别名: 2-Methyl-1-(4-sulfanylphenyl)propan-1-one
• CAS: 91358-97-3
• 化学式: C₁₀H₁₂OS
• 分子量: 180.271
• InChiKey: OWSRHZPVPADKSQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  18.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(4-Mercapto-phenyl)-2-methyl-propan-1-one 在 potassium triiodide 作用下， 以 氯仿 为溶剂， 以86%的产率得到1-[4-(4-Isobutyryl-phenyldisulfanyl)-phenyl]-2-methyl-propan-1-one
  参考文献：
  名称：

  The methyl group as a protectinq group for arylthiols: a mild and efficient method for the conversion of methyl aryl sulfides to arylthiols

  摘要：

  DOI：

  10.1016/s0040-4039(01)90033-4
• 作为产物：
  描述：

  p-(甲硫基)异丁酰苯 生成 1-(4-Mercapto-phenyl)-2-methyl-propan-1-one
  参考文献：
  名称：

  The methyl group as a protectinq group for arylthiols: a mild and efficient method for the conversion of methyl aryl sulfides to arylthiols

  摘要：

  DOI：

  10.1016/s0040-4039(01)90033-4

文献信息

• Novel 2-pyridinecarboxamide derivatives
  申请人：Mitsuya Morihiro

  公开号：US20060258701A1

  公开（公告）日：2006-11-16

  The present invention relates to a compound which has a glucokinase-activating effect and is useful as a therapeutic agent for diabetes mellitus, being represented by a formula (I): [wherein X 1 represents a nitrogen atom, sulfur atom, oxygen atom or the like; R 1 represents a 6- to 10-membered aryl group, 5- to 7-membered heteroaryl group or the like; D represents an oxygen atom or sulfur atom; R and R 3 are the same or different, each representing a hydrogen atom, lower alkyl group or the like; a formula (II) represents an optionally substituted 5- to 7-membered heteroaryl group or the like; a formula (III) represents a monocyclic or bicyclic heteroaryl group] or a pharmaceutically acceptable salt thereof.

  本发明涉及一种化合物，具有激活葡萄糖激酶的效果，并可用作糖尿病治疗剂，其化学式表示为（I）：[其中X1表示氮原子、硫原子、氧原子或类似物；R1表示6-至10-成员芳基基团、5-至7-成员杂芳基基团或类似物；D表示氧原子或硫原子；R和R3相同或不同，分别表示氢原子、低碳基或类似物；式（II）表示可选取代的5-至7-成员杂芳基团或类似物；式（III）表示单环或双环杂芳基团]或其药学上可接受的盐。
• NOVEL 2-PYRIDINECARBOXAMIDE DERIVATIVES
  申请人：MITSUYA MORIHIRO

  公开号：US20100041660A1

  公开（公告）日：2010-02-18

  The present invention relates to a compound which has a glucokinase-activating effect and is useful as a therapeutic agent for diabetes mellitus, being represented by a formula (I): [wherein X 1 represents a nitrogen atom, sulfur atom, oxygen atom or the like; R 1 represents a 6- to 10-membered aryl group, 5- to 7-membered heteroaryl group or the like; D represents an oxygen atom or sulfur atom; R 2 and R 3 are the same or different, each representing a hydrogen atom, lower alkyl group or the like; a formula (II) represents an optionally substituted 5- to 7-membered heteroaryl group or the like; a formula (III) represents a monocyclic or bicyclic heteroaryl group] or a pharmaceutically acceptable salt thereof.

  本发明涉及一种具有葡萄糖激酶激活作用并且可用作糖尿病治疗剂的化合物，其化学式为（I）：[其中X1代表氮原子、硫原子、氧原子或类似物；R1代表6到10个成员的芳基基团、5到7个成员的杂芳基团或类似物；D代表氧原子或硫原子；R2和R3相同或不同，每个代表氢原子、低碳基团或类似物；化学式（II）代表可选取代的5到7个成员的杂芳基团或类似物；化学式（III）代表单环或双环杂芳基团]或其药学上可接受的盐。
• YOUNG, R. N.;GAUTHJER, J. Y.;COOMBS, W., TETRAHEDRON LETT., 1984, 25, N 17, 1753-1756
  作者：YOUNG, R. N.、GAUTHJER, J. Y.、COOMBS, W.

  DOI：——

  日期：——
• US7629362B2
  申请人：——

  公开号：US7629362B2

  公开（公告）日：2009-12-08
• US8344003B2
  申请人：——

  公开号：US8344003B2

  公开（公告）日：2013-01-01