8-bromo-2,2-dimethyl-2H-pyrido[4,3-b][1,4]oxazin-3(4H)-one

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 8-bromo-2,2-dimethyl-2H-pyrido[4,3-b][1,4]oxazin-3(4H)-one
• 英文别名: 8-Bromo-2,2-dimethyl-4H-pyrido[4,3-B][1,4]oxazin-3-one；8-bromo-2,2-dimethyl-4H-pyrido[4,3-b][1,4]oxazin-3-one
• 化学式: C₉H₉BrN₂O₂
• 分子量: 257.087
• InChiKey: HHTZIRMUNPVEIU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  51.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  8-bromo-2,2-dimethyl-2H-pyrido[4,3-b][1,4]oxazin-3(4H)-one 在 硼烷四氢呋喃络合物 作用下， 以 四氢呋喃 为溶剂， 以3.5 g的产率得到8-bromo-2,2-dimethyl-3,4-dihydro-2H-pyrido[4,3-b][1,4]oxazine
  参考文献：
  名称：

  [EN] HETEROCYCLIC DERIVATIVES AS MALT1 INHIBITORS
  [FR] DÉRIVÉS HÉTÉROCYCLIQUES EN TANT QU'INHIBITEURS DE MALT1

  摘要：

  The present invention relates to compounds of formula (I) that are MALT1 inhibitors. The compounds have the structural formula I defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of diseases or disorders associated with MALT1.

  公开号：

  WO2023148501A1
• 作为产物：
  描述：

  3-溴-4-羟基-5-硝基吡啶 在 水 、 铁粉 、 potassium carbonate 、 氯化铵 作用下， 以 乙醇 、 乙腈 为溶剂， 反应 32.0h， 生成 8-bromo-2,2-dimethyl-2H-pyrido[4,3-b][1,4]oxazin-3(4H)-one
  参考文献：
  名称：

  [EN] HETEROCYCLIC DERIVATIVES AS MALT1 INHIBITORS
  [FR] DÉRIVÉS HÉTÉROCYCLIQUES EN TANT QU'INHIBITEURS DE MALT1

  摘要：

  The present invention relates to compounds of formula (I) that are MALT1 inhibitors. The compounds have the structural formula I defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of diseases or disorders associated with MALT1.

  公开号：

  WO2023148501A1

文献信息

• [EN] HETEROCYCLIC DERIVATIVES AS MALT1 INHIBITORS<br/>[FR] DÉRIVÉS HÉTÉROCYCLIQUES EN TANT QU'INHIBITEURS DE MALT1
  申请人：[en]C4X DISCOVERY LIMITED

  公开号：WO2023148501A1

  公开（公告）日：2023-08-10

  The present invention relates to compounds of formula (I) that are MALT1 inhibitors. The compounds have the structural formula I defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of diseases or disorders associated with MALT1.