(-)-Isoproterenol (+)-bitartrate salt | 14638-70-1

• 物质功能分类: 生物 - 生化试剂盒
• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (-)-Isoproterenol (+)-bitartrate salt
• 英文别名: 2,3-dihydroxybutanedioic acid;4-[1-hydroxy-2-(propan-2-ylamino)ethyl]benzene-1,2-diol
• CAS: 14638-70-1
• 化学式: C15H23NO9
• 分子量: 361.34
• InChiKey: LBOPECYONBDFEM-UHFFFAOYSA-N

物化性质

• 熔点：
  175 °C (dec.)(lit.)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.99
• 重原子数：
  25
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  188
• 氢给体数：
  8
• 氢受体数：
  10

安全信息

• 危险品标志：
  Xi
• 安全说明：
  S24/25
• 危险类别码：
  R36/37/38

文献信息

• Methods and systems of delivering medication via inhalation
  申请人：Next Safety, Inc.

  公开号：EP1902742A1

  公开（公告）日：2008-03-26

  Systems and methods for delivery of a drug to the respiratory system of a patient in a stream of purified air are provided. In particular, the drugs are delivered to the respiratory system of the patient at a positive air pressure relatvie to atmopheric pressure. With the systems and methods of the present disclosure, medication available in a variety of forms is introduced in a controlled fashion into the air stream in aerosol, nebulized, or vaporized form.

  提供了在净化空气流中向病人呼吸系统输送药物的系统和方法。特别是，药物是在相对于大气压的正气压下输送到病人的呼吸系统的。利用本公开的系统和方法，可将各种形式的药物以气溶胶、雾化或汽化的形式有控制地引入气流中。
• NOVEL TARGET TO TREAT A METABOLIC DISEASE IN AN INDIVIDUAL
  申请人：Universidad del Pais Vasco

  公开号：EP3620520A1

  公开（公告）日：2020-03-11

  Provided herein are methods, compounds, and compositions for reducing expression of MAT1a in a cell or individual. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate a metabolic disease or disorder in an individual.

  本文提供了减少细胞或个体中 MAT1a 表达的方法、化合物和组合物。这些方法、化合物和组合物有助于治疗、预防、延缓或改善个体的代谢性疾病或紊乱。
• Aerosol forming device for use in inhalation therapy
  申请人：Alexza Pharmaceuticals, Inc.

  公开号：US11065400B2

  公开（公告）日：2021-07-20

  Inhalation delivery of aerosols containing small particles is described. Specifically, it relates to a device that forms drug containing aerosols for use in inhalation therapy. In a device aspect of the present disclosure, a device for delivering drug containing aerosols for inhalation therapy is provided. The device includes a housing and an airway that has a gas/vapor mixing airway. The airway further includes a subassembly, which has a metallic substrate coated on its surface with a composition comprising a drug.

  描述了吸入输送含有小颗粒的气溶胶。具体来说，它涉及一种可形成用于吸入疗法的含药气溶胶的装置。在本公开的一个装置方面，提供了一种用于吸入疗法的含药气溶胶输送装置。该装置包括外壳和气道，气道具有气体/蒸汽混合气道。气道还包括一个子组件，该子组件的金属基板表面涂有包含药物的组合物。
• Delivery system for ayahuasca-like substances
  申请人：Ellis Gregory

  公开号：US11235110B1

  公开（公告）日：2022-02-01

  Provided herein is a delivery device and vaporizable formulations that provide users or patients with the ability to safely, reliably, and conveniently obtain a high-quality, therapeutic vapor comprising an ayahuasca-like substance. The delivery device includes a chamber coupled to a power unit capable of providing power to vaporize the formulations for consumption of the substance in a consistently desirable and safe manner. Further included are kits and methods of treating psychological disorders using the delivery device and vaporizable formulations provided herein.

  本文提供了一种给药装置和可蒸发制剂，使用户或患者能够安全、可靠、方便地获得包含死藤水样物质的高质量治疗性蒸汽。该给药装置包括一个腔室，该腔室与一个动力装置相连，动力装置能够提供动力，以持续、理想和安全的方式使制剂汽化，从而服用该物质。此外，还包括使用本发明提供的给药装置和可蒸发制剂治疗心理障碍的试剂盒和方法。
• Method of forming an aerosol for inhalation delivery
  申请人：——

  公开号：US20030015197A1

  公开（公告）日：2003-01-23

  The present invention relates to the inhalation delivery of aerosols containing small particles. Specifically, it relates to a method of forming an aerosol for use in inhalation therapy. In a method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug at a rate greater than 1000° C./s, thereby forming an vapor; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug to form a vapor, wherein the coated composition is in the form of a film less than 10&mgr; thick; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug to form a vapor in less than 100 milliseconds, wherein the vapor has a mass greater than 0.1 mg; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy.

  本发明涉及吸入输送含有小颗粒的气溶胶。具体而言，本发明涉及一种用于吸入治疗的气溶胶的形成方法。在本发明的方法方面，提供了一种用于吸入治疗的气溶胶的形成方法。该方法包括以下步骤：(a) 以大于 1000° C./s的速度加热涂有包含药物的组合物的基底，从而形成蒸气；以及，(b) 使蒸气冷却，从而形成用于吸入疗法的气溶胶。在本发明的另一个方法方面，提供了一种用于吸入疗法的气雾剂形成方法。该方法包括以下步骤：(a) 加热涂有包含药物的组合物的基底以形成蒸气，其中涂布的组合物呈厚度小于 10&mgr; 的薄膜形式；以及，(b) 使蒸气冷却，从而形成用于吸入疗法的气雾剂。在本发明的另一个方法方面，提供了一种用于吸入疗法的气雾剂的形成方法。该方法包括以下步骤：(a) 在小于 100 毫秒的时间内加热涂有包含药物的组合物的基底以形成蒸汽，其中蒸汽的质量大于 0.1 毫克；以及，(b) 使蒸汽冷却，从而形成用于吸入疗法的气雾剂。

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