2-dibutylamino-1-[6,8-dichloro-2-(3,4-dichloro-phenyl)-quinolin-4-yl]-ethanol | 57152-52-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-dibutylamino-1-[6,8-dichloro-2-(3,4-dichloro-phenyl)-quinolin-4-yl]-ethanol
• 英文别名: 2-dibutylamino-1-[6,8-dichloro-2-(3,4-dichloro-phenyl)-[4]quinolyl]-ethanol；2-Dibutylamino-1-[6,8-dichlor-2-(3,4-dichlor-phenyl)-[4]chinolyl]-aethanol；6,8-Dichloro-alpha-((dibutylamino)methyl)-2-(3,4-dichlorophenyl)-4-quinolinemethanol；2-(dibutylamino)-1-[6,8-dichloro-2-(3,4-dichlorophenyl)quinolin-4-yl]ethanol
• CAS: 57152-52-0
• 化学式: C₂₅H₂₈Cl₄N₂O
• 分子量: 514.322
• InChiKey: PGLJCSZNFGDTFZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.1
• 重原子数：
  32
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  36.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-dibutylamino-1-[6,8-dichloro-2-(3,4-dichloro-phenyl)-quinolin-4-yl]-ethanol 以80%的产率得到
  参考文献：
  名称：

  ATKINSON E. R., J. MED. CHEM. , 1974 17, NO 9, 1012-1013

  摘要：

  DOI：
• 作为产物：
  描述：

  二正丁胺 、 甲苯 、 alkaline earth salt of/the/ methylsulfuric acid 生成 2-dibutylamino-1-[6,8-dichloro-2-(3,4-dichloro-phenyl)-quinolin-4-yl]-ethanol
  参考文献：
  名称：

  抗疟药；7-氯-4-羟基-和4,7-二氯-1-甲基甲硫基。

  摘要：

  DOI：

  10.1021/ja01213a041

文献信息

• Compositions for the treatment of pancreatic cancer and uses thereof
  申请人：University of Florida Research Foundation, Incorporated

  公开号：US10835524B2

  公开（公告）日：2020-11-17

  The invention pertains to compositions comprising inhibitors of PI3K, AKT and/or mTOR, one or more 4-quinolinemethanols and a pharmaceutically acceptable excipient. These compositions can contain subtherapeutic amounts of each active ingredient (PI3K, AKT, mTOR, one or more 4-quinolinemethanols and various combinations thereof). The invention also provides a method of treating various forms of cancer, such as breast cancer, prostate cancer, multiple myeloma, hepatocyte carcinoma, brain cancer, lung cancer, non-small cell lung carcinoma, colorectal cancer, melanoma and/or pancreatic cancer.

  本发明涉及由 PI3K、AKT 和/或 mTOR 抑制剂、一种或多种 4-喹啉甲醇和药学上可接受的赋形剂组成的组合物。这些组合物可以包含亚治疗量的每种活性成分（PI3K、AKT、mTOR、一种或多种 4-喹啉甲醇及其各种组合）。本发明还提供了一种治疗各种形式癌症的方法，如乳腺癌、前列腺癌、多发性骨髓瘤、肝细胞癌、脑癌、肺癌、非小细胞肺癌、结直肠癌、黑色素瘤和/或胰腺癌。
• ATKINSON E. R., J. MED. CHEM. <JMCM-AR>, 1974 17, NO 9, 1012-1013
  作者：ATKINSON E. R.

  DOI：——

  日期：——
• CARROLL F. I.; BERRANG B.; LINN C. P., J. MED. CHEM., 1978, 21 NO 4, 326-330
  作者：CARROLL F. I.、 BERRANG B.、 LINN C. P.

  DOI：——

  日期：——
• COMPOSITIONS FOR THE TREATMENT OF CANCER AND USES THEREOF
  申请人：University of Florida Research Foundation Incorporated

  公开号：US20180177776A1

  公开（公告）日：2018-06-28

  The invention pertains to compositions comprising inhibitors of PI3K, AKT and/or mTOR, one or more 4-quinolinemethanols and a pharmaceutically acceptable excipient. These compositions can contain subtherapeutic amounts of each active ingredient (PI3K, AKT, mTOR, one or more 4-quinolinemethanols and various combinations thereof). The invention also provides a method of treating various forms of cancer, such as breast cancer, prostate cancer, multiple myeloma, hepatocyte carcinoma, brain cancer, lung cancer, non-small cell lung carcinoma, colorectal cancer, melanoma and/or pancreatic cancer.
• [EN] COMPOSITIONS FOR THE TREATMENT OF CANCER AND USES THEREOF<br/>[FR] COMPOSITIONS DESTINÉES AU TRAITEMENT DU CANCER, ET LEURS UTILISATIONS
  申请人：UNIV FLORIDA

  公开号：WO2016209688A1

  公开（公告）日：2016-12-29

  The invention pertains to compositions comprising inhibitors of PI3K, AKT and/or mTOR, one or more 4-quinolinemethanols and a pharmaceutically acceptable excipient. These compositions can contain subtherapeutic amounts of each active ingredient (PI3K, AKT, mTOR, one or more 4-quinolinemethanols and various combinations thereof). The invention also provides a method of treating various forms of cancer, such as breast cancer, prostate cancer, multiple myeloma, hepatocyte carcinoma, brain cancer, lung cancer, non- small cell lung carcinoma, colorectal cancer, melanoma and/or pancreatic cancer.