PAMAM树枝状聚合物,乙二胺核,1.0代 | 142986-44-5

• 物质功能分类: 催化剂及助剂 - 聚合物
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: PAMAM树枝状聚合物,乙二胺核,1.0代
• 英文名称: PAMAM G1
• 英文别名: poly(amidoamine) dendrimer (G1 generation)；PAMAM generation-1 amine dendrimer；G1-PAMAM；PAMAM dendrimer, generation 1；Starburst(R)(pamam)dendrimer,generation 1；N-(2-aminoethyl)-3-[[3-(2-aminoethylamino)-3-oxopropyl]-[2-[3-[[3-[2-[bis[3-(2-aminoethylamino)-3-oxopropyl]amino]ethylamino]-3-oxopropyl]-[2-[bis[3-[2-[bis[3-(2-aminoethylamino)-3-oxopropyl]amino]ethylamino]-3-oxopropyl]amino]ethyl]amino]propanoylamino]ethyl]amino]propanamide
• CAS: 142986-44-5
• 化学式: C₆₂H₁₂₈N₂₆O₁₂
• 分子量: 1429.87
• InChiKey: QVWIZHOFYGKROL-UHFFFAOYSA-N

物化性质

• 沸点：
  64.7 °C
• 密度：
  0.82 g/mL at 25 °C
• 闪点：
  52 °F

计算性质

• 辛醇/水分配系数(LogP)：
  -16.1
• 重原子数：
  100
• 可旋转键数：
  67
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.81
• 拓扑面积：
  577
• 氢给体数：
  20
• 氢受体数：
  26

安全信息

• 安全说明：
  S16,S23,S45,S7
• 危险类别码：
  R23/24/25,R39/23/24/25,R11
• WGK Germany：
  3
• 危险标志：
  GHS02,GHS06,GHS08
• 危险品运输编号：
  UN 1230 3/PG 2
• 危险性描述：
  H225,H301 + H311 + H331,H315,H319,H335,H370
• 危险性防范说明：
  P210,P260,P280,P301 + P310,P305 + P351 + P338,P311

反应信息

• 作为反应物：
  描述：

  PAMAM树枝状聚合物,乙二胺核,1.0代 在 盐酸 作用下， 以 水 为溶剂， 反应 6.0h， 生成
  参考文献：
  名称：

  Antimicrobial Efficacy of Synthesized Quaternary Ammonium Polyamidoamine Dendrimers and Dendritic Polymer Network

  摘要：

  Water treatment to mitigate microbial contaminants is a major challenge across globe paving the way to develop novel antimicrobial compounds. We aim at architecting antibacterial moiety eventually catering to vast water treatment industry. In this research study, quaternary ammonium functionalized polyamidoamine (PAMAM) dendrimer and PAMAM-ethyleneglycol dimethacrylate (EGDMA) dendritic polymer network were synthesized. These materials were characterized by various analytical techniques like ATR-FTIR, 1HNMR, DSC etc. Water soluble generation (G) 1.0 PAMAM dendrimer and water insoluble PAMAM G1.0 EGDMA dendritic polymer network were quaternized by reacting with dilute hydrochloric acid (HCI) and octyl iodide (01) respectively. Both quaternary ammonium dendrimer products were found to exhibit potent bactericidal activity against a group of common Gram-negative and Gram-positive bacteria. 10 mg/L concentration of liquid PAMAM G1.0 QHCI was efficient to kill 100% bacteria rapidly within an incubation time of just 2 minutes. In addition, quaternary ammonium dendritic polymer network PAMAM G1.0-EGDMA Q OI demonstrated good contact killing antimicrobial property without releasing any active molecule into the surrounding medium and disinfected contaminated water within 5 minutes. Both quaternary ammonium dendrimer and dendritic polymer network showed negligible cytotoxicity in MTT assay indicating their potential as a viable antimicrobial agent.

  DOI：

  10.1166/jnn.2016.10656
• 作为产物：
  描述：

  乙二胺 、 PAMAM G0.5 以 甲醇 为溶剂， 反应 48.0h， 生成 PAMAM树枝状聚合物,乙二胺核,1.0代
  参考文献：
  名称：

  烟酸在聚酰胺胺树枝状聚合物溶液中的溶解度。

  摘要：

  在本研究中，我们研究了乙二胺（EDA）核心聚酰胺酰胺（PAMAM）树状聚合物对烟酸的水溶性的影响。在室温下在蒸馏水中在树枝状大分子的存在下测量烟酸的水溶解度。研究了变量的影响，例如pH条件，浓度，表面官能团和树枝状聚合物的生成（分子大小）。结果表明，烟酸在树枝状聚合物溶液中的溶解度与树枝状聚合物的浓度成正比，胺和酯封端的树枝状大分子都导致烟酸在较高pH条件下溶解度的增加更大。树枝状大分子在恒定pH条件下增加溶解度的顺序为G4> G3> G2> G1。另外，在每个pH下 与具有相同数目的表面官能团的胺酯封端的树枝状大分子相比，在胺封端的树枝状大分子的存在下烟酸的溶解度更大。在合适的条件下，PAMAM树状聚合物可以非常有效地用于增强烟酸的溶解性。

  DOI：

  10.1016/j.ejmech.2005.08.001

文献信息

• ENCAPSULATION OF VITAMIN C INTO WATER SOLUBLE DENDRIMERS
  申请人：Astruc Didier

  公开号：US20110021626A1

  公开（公告）日：2011-01-27

  The invention relates to a conjugated dendrimer that comprises at least one water-soluble dendrimer and at least one vitamin C molecule. The conjugated dendrimer can be used e.g. for preparing cosmetic or pharmaceutical compositions. The dendrimers have a good vitamin C load capacity and are biocompatible.

  该发明涉及一种共轭树状聚合物，包括至少一种水溶性树状聚合物和至少一个维生素C分子。该共轭树状聚合物可用于制备化妆品或药用组合物。这些树状聚合物具有良好的维生素C负载能力，并且具有生物相容性。
• Use of Dendrimers to Stimulate Cell Growth
  申请人：Majoral Jean-Pierre

  公开号：US20090142316A1

  公开（公告）日：2009-06-04

  The present invention relates to the use of dendrimers with monophosphonic or bisphosphonic terminations in order to stimulate the growth of cell cultures or to activate cells in culture.

  本发明涉及在细胞培养中使用具有单磷酸或双磷酸端基的树枝状聚合物，以促进细胞培养的生长或激活细胞。
• A phosphorus–nitrogen containing dendrimer reduces the flammability of nanostructured polymers with embedded self-assembled gel networks
  作者：Guobo Huang、Jianguo Yang、Xu Wang、Jianrong Gao、Huading Liang

  DOI：10.1039/c2ta00246a

  日期：——

  A novel phosphorus–nitrogen containing dendrimer DPC–PAMAM has been obtained by the functionalization of amine terminated poly(amidoamine) (PAMAM) with diphenyl phosphoryl chloride (DPC), which is used to modify polyurethane (PU) as an intumescent flame retardant. The gel-phase network, made up of a number of nanofibers, is formed by the self-assembly of DPC–PAMAM dendrimer, which is embedded in the PU matrix by in situ polymerization. The results from thermogravimetric analysis (TGA) and cone calorimeter testing indicate that the addition of the DPC–PAMAM gelator improves thermal stability and reduces significantly the flammability (including peak heat release rate (PHRR), total heat release (THR), average mass loss rate (AMLR), etc.) of PU resin. Furthermore, incorporating the DPC–PAMAM gelator into the polymer matrix enhances the strength of PU resin. The scanning electron microscopy (SEM) images show that a compact and dense intumescent char is formed for PU composites filled with DPC–PAMAM after combustion, which results in the improvement of flame-retardant properties of the polymer matrix by condensed phase flame retardancy.

  一种新型含磷氮的树枝状高分子DPC–PAMAM是通过将氨基终止的聚（酰胺胺）（PAMAM）与二苯基磷酰氯（DPC）功能化得到的，该高分子用于将聚氨酯（PU）改性为膨胀型阻燃剂。由多个纳米纤维组成的凝胶相网络是通过DPC–PAMAM树枝状高分子的自组装形成的，该网络通过原位聚合嵌入PU基体中。热重分析（TGA）和锥形量热仪测试的结果表明，添加DPC–PAMAM凝胶剂可以提高PU树脂的热稳定性，并显著降低其可燃性（包括峰值热释放速率（PHRR）、总热释放量（THR）、平均质量损失率（AMLR）等）。此外，将DPC–PAMAM凝胶剂引入聚合物基体中增强了PU树脂的强度。扫描电子显微镜（SEM）图像显示，燃烧后填充有DPC–PAMAM的PU复合材料形成了致密且密集的膨胀炭，从而通过凝聚态阻燃性提高了聚合物基体的阻燃性能。
• Efficient modification of PAMAM G1 dendrimer surface with β-cyclodextrin units by CuAAC: impact on the water solubility and cytotoxicity
  作者：Kendra Sorroza-Martínez、Israel González-Méndez、Ricardo D. Martínez-Serrano、José D. Solano、Andrea Ruiu、Javier Illescas、Xiao Xia Zhu、Ernesto Rivera

  DOI：10.1039/d0ra02574g

  日期：——

  The toxicity of the poly(amidoamine) dendrimers (PAMAM) caused by the peripheral amino groups has been a limitation for their use as drug carriers in clinical applications.

  聚（酰胺胺）树状分子（PAMAM）由于外周氨基团引起的毒性限制了它们作为药物载体在临床应用中的使用。
• Interactions and Encapsulation of Vitamins C, B₃, and B₆with Dendrimers in Water
  作者：Elodie Boisselier、Liyuan Liang、Maria Dalko-Csiba、Jaime Ruiz、Didier Astruc

  DOI：10.1002/chem.200902995

  日期：2010.5.25

  (PAMAM) dendrimers by vitamins C (ascorbic acid, AA), B3 (nicotinic acid), and B6 (pyridoxine) were monitored by 1H NMR spectroscopy using the chemical shifts of both dendrimer and vitamin protons and analyzed by comparison with the titration of propylamine. Quaternarizations of the terminal primary amino groups and intradendritic tertiary amino groups, which are nearly quantitative with vitamin C, were

  维生素C（抗坏血酸，AA），B 3（烟酸）和B 6（吡ox醇）对商用二氨基丁烷（DAB）和聚酰胺基（PAMAM）树枝状聚合物的滴定通过1 H NMR光谱法进行监测，并使用了两种树枝状大分子的化学位移和维生素质子，并通过与丙胺滴定法进行比较进行分析。终端伯氨基和intradendritic叔氨基团，其与维生素C几乎定量的Quaternarizations进行表征通过更多或更少的尖锐变化（Δ δ所述的）1个ħ化学位移（δ）。DAB树状聚合物的外围伯氨基首先被季铵化，但不是选择性地进行季铵化，而在所有叔胺附近，内部亚甲基质子在叔胺附近记录到急剧的化学位移变化，从而表明了包封。对于DAB-G5-64-NH 2，需要一些过量的酸来使内部氨基质子化，这大概是由于过量电荷排斥导致碱度降低所致。另一方面，用PAMAM树状聚合物没有观察到这种选择性。维生素B 6滴定树枝状聚合物的特殊情况表示仅占优势的超分子