Sequinavir | 1349873-79-5

• 物质功能分类: 原料药 - 人工合成抗感染类药 - 抗病毒类药
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Sequinavir
• 英文别名: (2S)-N-[(2S,3R)-4-[(3S)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1-phenylbutan-2-yl]-2-(quinoline-2-carbonylamino)butanediamide
• CAS: 1349873-79-5
• 化学式: C₃₈H₅₀N₆O₅
• 分子量: 670.8
• InChiKey: QWAXKHKRTORLEM-LINFGICFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  49
• 可旋转键数：
  13
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  167
• 氢给体数：
  5
• 氢受体数：
  7

文献信息

• COMPOUNDS FOR TREATING VIRAL INFECTIONS
  申请人：Yager Kraig M.

  公开号：US20110144069A1

  公开（公告）日：2011-06-16

  The invention relates to compounds, pharmaceutical compositions and methods useful for treating viral infection.

  本发明涉及用于治疗病毒感染的化合物、制药组合物和方法。
• Tuneable delivery of nanoparticle bound active plasmin for the treatment of thrombosis
  申请人：Indiana University Research and Technology Corporation

  公开号：US11207282B2

  公开（公告）日：2021-12-28

  Compositions and methods for therapeutic delivery are disclosed. More particularly, the present disclosure relates to nanoparticle compositions that sequester the activity of a target molecule while leaving other domains accessible to bind targeted tissues of interest. Methods for thrombus dissolution include administering a nanoparticle reversibly coupled to a target molecule that can dissolve a blood clot. Compositions and methods for inducing blood clotting are also disclosed. Methods for inducing blood clotting include administering a nanoparticle reversibly coupled to a target molecule that can induce the formation of a blood clot. Methods for sequestering a target molecule are also disclosed. The method includes reversibly coupling a target molecule to a nanoparticle having an affinity ligand that reversibly couples the target molecule, and thus, sequesters the target molecule activity until the target molecule interacts with its substrate resulting in the release of the target molecule.

  本发明公开了用于治疗递送的组合物和方法。更具体地说，本公开涉及纳米颗粒组合物，该组合物可封闭目标分子的活性，同时保留其他可接触的结构域以结合感兴趣的目标组织。溶解血栓的方法包括施用与目标分子可逆耦合的纳米粒子，该目标分子可溶解血栓。还公开了诱导血液凝结的组合物和方法。诱导血液凝结的方法包括施用与可诱导血凝块形成的靶分子可逆耦合的纳米粒子。还公开了封存目标分子的方法。该方法包括将目标分子可逆地偶联到具有亲和配体的纳米粒子上，亲和配体可逆地偶联目标分子，从而封存目标分子的活性，直到目标分子与其底物相互作用导致目标分子释放。
• PYRROLOBENZODIAZEPINE RESISTANCE
  申请人：ADC Therapeutics SA

  公开号：EP3899048A1

  公开（公告）日：2021-10-27
• TUNEABLE DELIVERY OF NANOPARTICLE BOUND ACTIVE PLASMIN FOR THE TREATMENT OF THROMBOSIS
  申请人：INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION

  公开号：US20200261386A1

  公开（公告）日：2020-08-20

  Compositions and methods for therapeutic delivery are disclosed. More particularly, the present disclosure relates to nanoparticle compositions that sequester the activity of a target molecule while leaving other domains accessible to bind targeted tissues of interest. Methods for thrombus dissolution include administering a nanoparticle reversibly coupled to a target molecule that can dissolve a blood clot. Compositions and methods for inducing blood clotting are also disclosed. Methods for inducing blood clotting include administering a nanoparticle reversibly coupled to a target molecule that can induce the formation of a blood clot. Methods for sequestering a target molecule are also disclosed. The method includes reversibly coupling a target molecule to a nanoparticle having an affinity ligand that reversibly couples the target molecule, and thus, sequesters the target molecule activity until the target molecule interacts with its substrate resulting in the release of the target molecule.
• METHODS FOR TREATING FLAVIVIRUSES AND ZIKA INFECTIONS
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：US20210052621A1

  公开（公告）日：2021-02-25

  There are provided, inter alia, methods of treatment of Zika virus infection.