S-[5-(乙酰氨基)-2-羟基苯基]-L-半胱氨酸 | 53446-10-9

• 物质功能分类: 生物化工 - 氨基酸及其衍生物 - 半胱氨酸类衍生物
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: S-[5-(乙酰氨基)-2-羟基苯基]-L-半胱氨酸
• 中文别名: S-[5 - (乙酰氨基)- 2 -羟基苯基] - L -半胱氨酸
• 英文名称: (2R)-3-(5-acetamido-2-hydroxyphenyl)sulfanyl-2-azaniumylpropanoate
• CAS: 53446-10-9
• 化学式: C11H14N2O4S
• 分子量: 270.31
• InChiKey: LLHICPSCVFRWDT-QMMMGPOBSA-N

物化性质

• 熔点：
  190-193°C dec.
• 溶解度：
  可溶于水基（轻微）、DMSO（轻微、超声处理）、甲醇（轻微）

计算性质

• 辛醇/水分配系数(LogP)：
  -2.3
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  138
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• Anti-acetaminophen antibodies and acetaminophen protein adducts
  申请人：BioVentures, LLC

  公开号：US10570216B2

  公开（公告）日：2020-02-25

  The present disclosure provides isolated antibodies that bind to acetaminophen-protein adducts that are useful in the detection and diagnosis of acetaminophen-induced toxicity.

  本公开提供了与对乙酰氨基酚-蛋白质加合物结合的分离抗体，可用于检测和诊断对乙酰氨基酚引起的毒性。
• Small molecule metabolites for the diagnosis of bacterial vaginosis and assessment of disease risk
  申请人：Fred Hutchinson Cancer Research Center

  公开号：US10690651B2

  公开（公告）日：2020-06-23

  The invention disclosed herein generally relates to methods and kits for diagnosing, assessing disease risk, treating, and preventing bacterial vaginosis (BV) and associated conditions. Additional embodiments include methods for developing metabolic profiles associated with increased disease risk, and developing new approaches to treat BV based on interrupting metabolic networks.

  本文公开的发明一般涉及诊断、评估疾病风险、治疗和预防细菌性阴道病（BV）及相关疾病的方法和试剂盒。其他实施方案包括开发与疾病风险增加相关的代谢图谱的方法，以及开发基于干扰代谢网络治疗 BV 的新方法。
• Blood and tissue sample assessment of mitochondrial function and biochemistry as a tool for selection for feed efficiency and other production parameters
  申请人：Bottje Walter

  公开号：US20060154255A1

  公开（公告）日：2006-07-13

  The present invention provides methods for predicting feed efficiency in animals by correlating the association of mitochondrial function with feed efficiency. In one embodiment, the invention provides a method for determining feed efficiency comprising comparing proteins patterns and activity levels with antibody interaction of proteins associated with mitochondrial function and feed efficiency. In an alternative embodiment, the present invention also provides methods for predicting feed efficiency in animals by identifying animals having genetic mutations or polymorphisms that are associated with mitochondrial function and feed efficiency.

  本发明提供了通过线粒体功能与饲料效率的关联预测动物饲料效率的方法。在一个实施方案中，本发明提供了一种确定饲料效率的方法，包括比较与线粒体功能和饲料效率相关的蛋白质模式和活性水平与抗体相互作用。在另一个实施方案中，本发明还提供了通过鉴定具有与线粒体功能和饲料效率相关的基因突变或多态性的动物来预测动物饲料效率的方法。
• HIGH FLUORESCENCE SPECIFIC IMMUNE ENHANCING FACTOR AND METHODS OF USE FOR SAME
  申请人：BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA

  公开号：EP0873136B1

  公开（公告）日：2004-10-13
• METABOLOMIC PROFILING DEFINES ONCOGENES DRIVING PROSTATE TUMORS
  申请人：Dana-Farber Cancer Institute, Inc.

  公开号：EP2929352B1

  公开（公告）日：2018-11-21