2,2,4-Trimethyl-1,2-dihydroquinolin-6-yl benzoate | 5493-40-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2,2,4-Trimethyl-1,2-dihydroquinolin-6-yl benzoate
• 英文别名: (2,2,4-trimethyl-1H-quinolin-6-yl) benzoate
• CAS: 5493-40-3
• 化学式: C₁₉H₁₉NO₂
• mdl: MFCD00809935
• 分子量: 293.4
• InChiKey: OEEHFISDBQJLJD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• COMPOSITIONS AND METHODS RELATING TO HIV PROTEASE INHIBITION
  申请人：Carlson Heather A.

  公开号：US20110105477A1

  公开（公告）日：2011-05-05

  The present invention relates to HIV protease, and methods for inhibiting the function of HIV protease. In particular, present invention provides compounds that inhibit or block the biological activity of HIVp, thereby causing the replication of the HIV virus to be inhibited or to terminate. These compounds, as well as pharmaceutical compositions that contain these compounds and optionally other anti-viral agents as active ingredients, are suitable for treating patients or hosts infected with the HIV virus, which is known to cause AIDS. The compounds and formulations also find use in diagnostic and research settings.
• [EN] COMPOSITIONS AND METHODS RELATING TO HIV PROTEASE INHIBITION<br/>[FR] COMPOSITIONS ET PROCÉDÉS LIÉS À L'INHIBITION DE LA VIH PROTÉASE
  申请人：UNIV MICHIGAN

  公开号：WO2009036341A2

  公开（公告）日：2009-03-19

  The present invention relates to HIV protease, and methods for inhibiting the function of HIV protease. In particular, present invention provides compounds that inhibit or block the biological activity of HIVp, thereby causing the replication of the HIV virus to be inhibited or to terminate. These compounds, as well as pharmaceutical compositions that contain these compounds and optionally other anti-viral agents as active ingredients, are suitable for treating patients or hosts infected with the HIV virus, which is known to cause AIDS. The compounds and formulations also find use in diagnostic and research settings.