2-Acetylamino-5-methyl-4-phenyl-thiophene-3-carboxylic acid ethyl ester | 43088-45-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-Acetylamino-5-methyl-4-phenyl-thiophene-3-carboxylic acid ethyl ester
• 英文别名: Ethyl 2-acetamido-5-methyl-4-phenylthiophene-3-carboxylate
• CAS: 43088-45-5
• 化学式: C₁₆H₁₇NO₃S
• mdl: MFCD00416485
• 分子量: 303.382
• InChiKey: HHHALVHWBGMWOB-UHFFFAOYSA-N

物化性质

• 沸点：
  466.8±45.0 °C(Predicted)
• 密度：
  1.223±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  83.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-Acetylamino-5-methyl-4-phenyl-thiophene-3-carboxylic acid ethyl ester 在 一水合肼 作用下， 反应 24.0h， 以61.2%的产率得到3-Amino-2,6-dimethyl-5-phenyl-3H-thieno[2,3-d]pyrimidin-4-one
  参考文献：
  名称：

  Functional derivatives of thiophen XX. Synthesis and antiviral activity of 3-aminothieno[2,3-d]pyrimidines

  摘要：

  DOI：

  10.1007/bf00760666

文献信息

• Compounds, Formulations, and Methods of Protein Kinase C Inhibition
  申请人：Antonetti David A.

  公开号：US20120302561A1

  公开（公告）日：2012-11-29

  The invention provides a method of inhibiting atypical protein kinase C (aPKC) comprising contacting an aPKC with a compound having a structure selected from the group consisting of structural formulas (I) to (IX). The invention further provides a method of inhibiting or reducing vascular permeability. The method comprising administering to a subject a composition comprising an amount of a compound having a structure selected from the group consisting of structural formulas (I) to (IX) effective to inhibit or reduce vascular permeability. A method of treating or preventing a disease or disorder characterized by abnormal vascular permeability, a method of inhibiting angiogenesis, a method of inhibiting cancer cell proliferation, a formulation, and a method of preparing a formulation also are provided.
• US8889672B2
  申请人：——

  公开号：US8889672B2

  公开（公告）日：2014-11-18
• [EN] COMPOUNDS, FORMULATIONS, AND METHODS OF PROTEIN KINASE C INHIBITION<br/>[FR] COMPOSÉS, FORMULATIONS ET PROCÉDÉS D'INHIBITION DE LA PROTÉINE KINASE C
  申请人：UNIV MICHIGAN

  公开号：WO2012149452A1

  公开（公告）日：2012-11-01

  The invention provides a method of inhibiting atypical protein kinase C (aPKC) comprising contacting an aPKC with a compound having a structure selected from the group consisting of structural formulas (I) to (IX). The invention further provides a method of inhibiting or reducing vascular permeability. The method comprising administering to a subject a composition comprising an amount of a compound having a structure selected from the group consisting of structural formulas (I) to (IX) effective to inhibit or reduce vascular permeability. A method of treating or preventing a disease or disorder characterized by abnormal vascular permeability, a method of inhibiting angiogenesis, a method of inhibiting cancer cell proliferation, a formulation, and a method of preparing a formulation also are provided.
• Functional derivatives of thiophen XX. Synthesis and antiviral activity of 3-aminothieno[2,3-d]pyrimidines
  作者：I. A. Kharizomenova、A. N. Grinev、N. V. Samsonova、E. K. Panisheva、N. V. Kaplina、I. S. Nikolaeva、T. V. Pushkina、G. N. Pershin

  DOI：10.1007/bf00760666

  日期：1981.9