4,7-diphenylphenanthroline sulfonate | 68399-83-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4,7-diphenylphenanthroline sulfonate
• 英文别名: 4,7-Diphenyl-1,10-phenanthroline-1,10-diium;sulfate；4,7-diphenyl-1,10-phenanthroline-1,10-diium;sulfate
• CAS: 68399-83-7
• 化学式: C₂₄H₁₆N₂*H₂O₄S
• 分子量: 430.484
• InChiKey: BAPOQDKEZPBWEY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.46
• 重原子数：
  31
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  109
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  {Rh(bipyridine)2}Cl 、 4,7-diphenylphenanthroline sulfonate 以 水 为溶剂， 生成 [bis(4,7-diphenylphenanthroline)rhodium(I)]Cl
  参考文献：
  名称：

  Nature of bis(2,2'-bipyridine)rhodium(I) in aqueous solutions

  摘要：

  DOI：

  10.1021/ic00141a023

文献信息

• DETECTION OF PHOSPHO-SERINE 129 ALPHA-SYNUCLEIN IN BLOOD CELLS AS A BIOMARKER FOR SYNUCLEINOPATHIES
  申请人：YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD

  公开号：EP3765855A1

  公开（公告）日：2021-01-20
• US4245041A
  申请人：——

  公开号：US4245041A

  公开（公告）日：1981-01-13
• [EN] REGULATOR OF BMP-SMAD SIGNALING AND USES THEREOF<br/>[FR] RÉGULATEUR DE SIGNALISATION DE BMP-SMAD ET SES UTILISATIONS
  申请人：OSPEDALE SAN RAFFAELE SRL

  公开号：WO2018185341A1

  公开（公告）日：2018-10-11

  The present invention relates to a regulator of the BMP-SMAD signaling for use in the treatment and/or prevention of a disease selected from the group consisting of: a disease characterized by ineffective erythropoiesis, anemia, a disease characterized by low hepcidin and by iron overload or a combination thereof. Preferably said regulator is an inhibitor of erythroid TFR2 or an inhibitor of hepatocyte FKBP12 or a combination thereof. The present invention also refers to relative pharmaceutical compositions and uses thereof.
• [EN] DETECTION OF PHOSPHO-SERINE 129 ALPHA-SYNUCLEIN IN BLOOD CELLS AS A BIOMARKER FOR SYNUCLEINOPATHIES<br/>[FR] DÉTECTION DE PHOSPHO-SÉRINE 129 ALPHA-SYNUCLÉINE DANS DES CELLULES SANGUINES EN TANT QUE BIOMARQUEUR POUR SYNUCLÉINOPATHIES
  申请人：YISSUM RES DEV CO OF HEBREW UNIV JERUSALEM LTD

  公开号：WO2019175883A1

  公开（公告）日：2019-09-19

  The present invention relates to diagnostic methods and kits for the detection and/or diagnosis of at least one synucleinopathy in a subject. More particularly, the invention provides the use of a-Syn and its post translational modifications, specifically, serine 129 phosphorylated a-Syn, as diagnostic markers for Parkinson's disease specifically, for the diagnosis of PD with motor symptoms (PD-M).