Glycyl-aspartyl-aspartyl-aspartyl-aspartyl-lysine-2-naphthylamide | 70023-02-8

• 物质功能分类: 生物化工 - 氨基酸及其衍生物 - 天冬酰胺类衍生物
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Glycyl-aspartyl-aspartyl-aspartyl-aspartyl-lysine-2-naphthylamide
• 英文别名: (3S)-3-[(2-aminoacetyl)amino]-4-[[(2S)-1-[[(2S)-1-[[1-[[(2S)-6-amino-1-(naphthalen-2-ylamino)-1-oxohexan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-4-oxobutanoic acid
• CAS: 70023-02-8
• 化学式: C₃₄H₄₄N₈O₁₄
• 分子量: 788.8
• InChiKey: QLLWULMEPVZWTP-VPRBCIFISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -8.1
• 重原子数：
  56
• 可旋转键数：
  24
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  376
• 氢给体数：
  12
• 氢受体数：
  16

安全信息

• 危险品标志：
  Xn
• 安全说明：
  S22,S36
• 危险类别码：
  R40
• WGK Germany：
  3
• 危险标志：
  GHS08
• 危险性描述：
  H351
• 危险性防范说明：
  P281

文献信息

• Production of biologically active proteins
  申请人：ERA Biotech, S.A.

  公开号：EP2351834A2

  公开（公告）日：2011-08-03

  A fusion protein that is expressed in a recombinant protein body-like assembly (RPBLA) in host eukaryotic cells and organisms is disclosed. More particularly, a biologically active polypeptide fused to a protein sequence that mediates the induction of RPBLA formation is expressed and accumulated in host cells after transformation with an appropriate vector. The eukaryotic host cell does not produce protein bodies in the absence of the fusion protein. Methods for preparing and using the RPBLAs and the fusion protein are also disclosed, as are nucleic acid molecules that encode the fusion proteins.

  本发明公开了一种在宿主真核细胞和生物体内以重组蛋白体样装配（RPBLA）形式表达的融合蛋白。更具体地说，在用适当的载体转化后，一种与介导 RPBLA 形成的蛋白质序列融合的生物活性多肽在宿主细胞中表达和积累。真核宿主细胞在没有融合蛋白的情况下不会产生蛋白体。此外，还公开了制备和使用 RPBLA 和融合蛋白的方法，以及编码融合蛋白的核酸分子。
• Protein body-inducing polypeptide sequences
  申请人：ERA Biotech, S.A.

  公开号：EP2418284A1

  公开（公告）日：2012-02-15

  Polypeptide sequences for inducing recombinant protein bodies are described. The sequences comprise a polyproline II (PPII) structure between two cysteine residues on either end and an ER signal sequence Recombinant protein bodies are useful for protein production because they allow for simple and efficient purification of high quantities of recombinant protein. In addition, other methods of using recombinant protein bodies, for example, in vaccination, are also described.

  本文描述了用于诱导重组蛋白体的多肽序列。这些序列包括位于两个半胱氨酸残基两端之间的多脯氨酸 II（PPII）结构和一个 ER 信号序列 重组蛋白体可用于蛋白质的生产，因为它们可以简单高效地纯化大量重组蛋白。此外，还介绍了使用重组蛋白体的其他方法，例如用于疫苗接种。
• PRODUCTION OF BIOLOGICALLY ACTIVE PROTEINS
  申请人：ERA Biotech, S.A.

  公开号：EP1994145A2

  公开（公告）日：2008-11-26
• PROTEIN BODY-INDUCING POLYPEPTIDE SEQUENCES
  申请人：Zera Intein Protein Solutions, S.L.

  公开号：EP2576797B1

  公开（公告）日：2017-01-25
• Recombinant Protein Body-Inducing Polypeptides
  申请人：Ludevid Múgica Maria Dolores

  公开号：US20110305718A1

  公开（公告）日：2011-12-15

  Polypeptide sequences for inducing recombinant protein bodies are described. The sequences comprise a polyproline II (PPII) structure and/or a proline-rich sequence between two cysteine residues on either end. Recombinant protein bodies are useful for protein production because they allow for simple and efficient purification of high quantities of recombinant protein. In addition, other methods of using recombinant protein bodies, for example, in vaccination and food products, are also described.