[(二甲基氨基)亚甲基]丙二酸 | 773109-21-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: [(二甲基氨基)亚甲基]丙二酸
• 中文别名: 5-苯氧基-4-氟-2-硝基苯甲胺(9CI)
• 英文名称: 2-[(dimethylamino)methylene]malonate
• 英文别名: 2-((Dimethylamino)methylene)malonic acid；2-(dimethylaminomethylidene)propanedioic acid
• CAS: 773109-21-0
• 化学式: C₆H₉NO₄
• mdl: MFCD06208292
• 分子量: 159.142
• InChiKey: CWSBYKYBZZIHSS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  77.8
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  异香兰素 、 [(二甲基氨基)亚甲基]丙二酸 在 甲醇 、 三氟乙酸 作用下， 以 氘代氯仿 为溶剂， 反应 16.0h， 生成 异阿魏酸
  参考文献：
  名称：

  Catalytic enamines from dialkylamide-dialkylacetals

  摘要：

  The formation of a transient enamine derived from DMF-DMA provides an effective alternative to the harsh conditions normally required for the nucleophilic addition of base-activated methylene compounds to a carbonyl group. Organocatalysts formed from dialkylamide-diallcylacetals in this manner may provide extensive synthetic utility for a number of well-established reactions in which the formation of enolates and enamines has been employed. Crown Copyright (C) 2012 Published by Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.03.028
• 作为产物：
  描述：

  丙二酸 、 N,N-二甲基甲酰胺 在 N,N-二甲基乙酰胺 作用下， 生成 [(二甲基氨基)亚甲基]丙二酸
  参考文献：
  名称：

  Catalytic enamines from dialkylamide-dialkylacetals

  摘要：

  The formation of a transient enamine derived from DMF-DMA provides an effective alternative to the harsh conditions normally required for the nucleophilic addition of base-activated methylene compounds to a carbonyl group. Organocatalysts formed from dialkylamide-diallcylacetals in this manner may provide extensive synthetic utility for a number of well-established reactions in which the formation of enolates and enamines has been employed. Crown Copyright (C) 2012 Published by Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.03.028

文献信息

• [EN] SUBSTITUTED NITROGEN CONTAINING COMPOUNDS<br/>[FR] COMPOSÉS CONTENANT DE L'AZOTE SUBSTITUÉ
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2018222795A1

  公开（公告）日：2018-12-06

  Disclosed are compounds of Formula (I): or a salt thereof, Formula (II) wherein R1 is: or; each W is independently NR1b or O; Z is a bond or CHR1d; and R1, R2, Rd, R3a, R3b, L1, B, V, Y, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of ROMK, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating cardiovascular diseases.

  揭示了以下式（I）的化合物或其盐，式（II）其中R1是：或；每个W独立地是NR1b或O；Z是键或CHR1d；以及R1、R2、Rd、R3a、R3b、L1、B、V、Y和n在此处被定义。还揭示了将这些化合物用作ROMK抑制剂的方法，以及包含这些化合物的药物组合物。这些化合物在治疗心血管疾病方面是有用的。
• SUBSTITUTED NITROGEN CONTAINING COMPOUNDS
  申请人：Bristol-Myers Squibb Company

  公开号：EP3630752A1

  公开（公告）日：2020-04-08
• [EN] SUSTAINABLE, ENERGY-CURABLE POLYESTER POLYOLS AND COATINGS OR RIGID FOAMS THEREFROM<br/>[FR] POLYESTERPOLYOLS DURABLES, DURCISSABLES PAR APPORT D'ÉNERGIE, ET REVÊTEMENTS OU MOUSSES RIGIDES OBTENUS À PARTIR DE CES DERNIERS
  申请人：RESINATE MAT GROUP INC

  公开号：WO2018160911A1

  公开（公告）日：2018-09-07

  Maleate polyester polyols and coatings made from the polyols are disclosed. The polyester polyols comprise recurring units of (a) a digested thermoplastic polyester or an aromatic dicarboxylate source; (b) a diol; (c) 5 to 95 mole % of an α,β-unsaturated monomer; and (d) 5 to 95 mole % of adipic acid, succinic acid, or a mixture thereof, where the mole % ranges for (c) and (d) are based on the combined molar amounts of (c) and (d). The polyols have hydroxyl numbers within the range of 25 to 450 mg KOH/g, an average of 0.5 to 2.5 reactive unsaturation sites per molecule, and a viscosity less than 1500 cP at 75°C. The polyols are thermally curable or energy- curable. Coatings made from the maleate polyester polyols are also described. Traditional coatings based on polyisocyanates and/or (meth)acrylates can be made, in some cases with improved properties and reduced reliance on the acrylate or isocyanate-based components. Surprisingly, the maleate polyester polyols can also be cured directly using UV to produce coatings under ambient conditions without the need for either acrylic or isocyanate functionality, and this allows coating formulators to reduce cost and more easily achieve regulatory compliance without sacrificing important coating properties. Rigid polyisocyanurate and polyurethane foams produced from the maleate polyester polyols have improved fire retardance.