S-(2-nitrobenzyl)-L-cysteine | 61543-53-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: S-(2-nitrobenzyl)-L-cysteine
• 英文别名: 2-azaniumyl-3-[(2-nitrophenyl)methylsulfanyl]propanoate
• CAS: 61543-53-1
• 化学式: C₁₀H₁₂N₂O₄S
• mdl: MFCD09949803
• 分子量: 256.282
• InChiKey: QLUTZSRKFWJIGM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  139
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  S-(2-nitrobenzyl)-L-cysteine 在 N-甲基吗啉 、 4-二甲氨基吡啶 sodium dithionite 、 potassium tert-butylate 、 一水合肼 作用下， 以 1,4-二氧六环 、 乙醇 、 二氯甲烷 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 46.0h， 生成 (3-Amino-2-oxo-3,4-dihydro-2H,6H-benzo[c][1,5]thiazocin-1-yl)-acetic acid tert-butyl ester
  参考文献：
  名称：

  Synthesis of a new dipeptide-type 5,1-benzothiazocine system

  摘要：

  DOI：

  10.1016/s0040-4039(00)80047-7

文献信息

• Chemically patterned hydrogels, manufacture and use thereof
  申请人：Shoichet Molly

  公开号：US20080286360A1

  公开（公告）日：2008-11-20

  A chemically patterned modified hydrogel formed from a modified hydrogel is provided. The hydrogel is conjugated with a multiphoton photocleavable molecule. The molecule has a multiphoton-labile protective group and a protected group. The protective group is cleavable upon multiphoton excitation to deprotect the protected group, without substantial polymerization of the hydrogel. The chemically patterned modified hydrogel is formed by exposing the modified hydrogel to multiphoton excitation to deprotect a portion of the protected groups.

  提供了一种化学图案化的改性水凝胶，该水凝胶由改性水凝胶形成。水凝胶与多光子光可裂解分子偶联。该分子具有多光子敏感保护基团和受保护基团。保护基团在多光子激发下可裂解，以解除对受保护基团的保护，而不会显著聚合水凝胶。通过将改性水凝胶暴露于多光子激发以解除部分受保护基团的保护，形成化学图案化的改性水凝胶。
• LYSINE COMPOUNDS AND THEIR USE IN SITE- AND CHEMOSELECTIVE MODIFICATION OF PEPTIDES AND PROTEINS
  申请人：Ovaa Huib

  公开号：US20120135913A1

  公开（公告）日：2012-05-31

  The present invention concerns new thiolysine and selenolysine compounds that can be used as building blocks for peptides and proteins, providing ligation handles for site- and chemoselective modification of said peptides and proteins. In particular, the invention provides. In particular, the invention provides (the use of) the compounds 5-thiolysine (also referred to as δ-thiolysine); 4-thiolysine (also referred to as γ-thiolysine); 5-selenolysine (also referred to as δ-selenolysine) and 4-selenolysine (also referred to as γ-selenolysine). The positioning of the thiol or selenol group at the respective carbon atom allows for a very efficient intramolecular transfer reaction to take place after conjugation with a selected ligand, and the thiol or selenol group may subsequently be removed using reported procedures, thereby restoring the native lysine structure, or be used as an additional conjugation handle. The methodology is fast and gives well-defined material.

  本发明涉及新的巯基赖氨酸和硒基赖氨酸化合物，可用作肽和蛋白质的构建块，为所述肽和蛋白质的位点和化学选择性修饰提供连接手柄。具体而言，本发明提供了化合物5-巯基赖氨酸（也称为δ-巯基赖氨酸）；4-巯基赖氨酸（也称为γ-巯基赖氨酸）；5-硒基赖氨酸（也称为δ-硒基赖氨酸）和4-硒基赖氨酸（也称为γ-硒基赖氨酸）的使用。将巯基或硒基团位于相应的碳原子上，可在与所选配体共轭后发生非常高效的分子内转移反应，巯基或硒基团随后可使用已知的程序去除，从而恢复天然的赖氨酸结构，或用作额外的连接手柄。该方法快速且给出明确的材料。
• Matrices comprising modified polysaccharides and modified polysaccharides
  申请人：Albert-Ludwigs-Universität Freiburg

  公开号：EP2735318A1

  公开（公告）日：2014-05-28

  The present invention discloses a matrix comprising a modified primary hydroxyl groups containing polysaccharide comprising repeating disaccharide units wherein in at least part of the disaccharide units the primary hydroxyl group is replaced by functional groups selected from halide groups or groups comprising sulfur or phosphorus atoms, like e.g. sulfate groups, sulfonate groups, phosphonate groups and phosphate groups.

  本发明公开了一种基质，该基质包含含有改性伯羟基的多糖，该多糖包含重复的二糖单元，其中至少有一部分二糖单元中的伯羟基被官能团取代，官能团选自卤化物基团或包含硫原子或磷原子的基团，如硫酸酯基团、磺酸酯基团、膦酸酯基团和磷酸酯基团。
• PIF1-LIKE HELICASE AND APPLICATION THEREOF
  申请人：Qitan Technology Ltd., Beijing

  公开号：EP4063382A9

  公开（公告）日：2022-11-16

  A modified Pifl-like helicase, a construct containing a Pifl-like helicase, and an application thereof in characterizing a target polynucleotide or controlling the movement of a target polynucleotide passing through pores. The present invention also relates to a method for characterizing a target polynucleotide or controlling the movement of a target polynucleotide passing through pores. The Pifl-like helicase can effectively control the movement of a polynucleotide passing through pores and increase the accuracy of a chain sequencing process.

  一种改进的类 Pifl 螺旋酶、一种含有类 Pifl 螺旋酶的构建体及其在表征目标多核苷酸或控制目标多核苷酸穿过孔隙的运动中的应用。本发明还涉及一种表征目标多核苷酸或控制目标多核苷酸穿过孔隙的方法。Pifl 样螺旋酶可有效控制穿过孔隙的多核苷酸的运动，提高链测序过程的准确性。
• Antibodies and methods for treating estrogen receptor-associated diseases
  申请人：BEIJING SHENOGEN PHARMA GROUP LTD.

  公开号：US10233249B2

  公开（公告）日：2019-03-19

  Provided herein in certain embodiments are antibodies, antibody fragments, pharmaceutical compositions, methods for modulating the functions of estrogen receptor alpha 36, and methods for preventing and/or treating diseases mediated by estrogen receptor alpha 36.

  本文在某些实施方案中提供了抗体、抗体片段、药物组合物、调节雌激素受体α36功能的方法以及预防和/或治疗由雌激素受体α36介导的疾病的方法。