2,3,5,6-Tetrachloro-4-methylbenzenesulfonic acid | 2077-49-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,3,5,6-Tetrachloro-4-methylbenzenesulfonic acid
• CAS: 2077-49-8
• 化学式: C₇H₄Cl₄O₃S
• 分子量: 310.0
• InChiKey: XJPGVEGFLLZVAY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  62.8
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Process for producing 2,6-difluorobenzonitrile
  申请人：ISHIHARA SANGYO KAISHA, LTD.

  公开号：EP0073372A1

  公开（公告）日：1983-03-09

  A process for producing 2,6-difluorobenzonitrile comprises reducing a chloro fluorobenzonitrile selected from 3- chtoro-2,6-difluorobenzonitrile, 3,5-dichloro-2,6-difluorobenzonitrile or a mixture thereof by hydrogen gas in the presence of a palladium or platinum catalyst at a temperature of 0 to 200 °C.

  一种生产 2,6-二氟苯腈的工艺包括在钯或铂催化剂存在下，用氢气在 0 至 200 ℃ 的温度下还原选自 3-氯-2,6-二氟苯腈、3,5-二氯-2,6-二氟苯腈或它们的混合物的氯氟苯腈。
• US4406841A
  申请人：——

  公开号：US4406841A

  公开（公告）日：1983-09-27
• [EN] IMMUNOCONJUGATE SYNTHESIS METHOD<br/>[FR] PROCÉDÉ DE SYNTHÈSE D'IMMUNOCONJUGUÉ
  申请人：BOLT BIOTHERAPEUTICS INC

  公开号：WO2021046347A1

  公开（公告）日：2021-03-11

  The invention provides a method for producing an immunoconjugate, the method comprising combining one or more compounds of Formula I and an antibody construct of Formula II to provide the immunoconjugate of Formula III, wherein TA is a therapeutic agent, L is a linker, r is an integer from 1 to 50, Ar is an aromatic moiety comprising a substituent selected from PEG, ‑SO2CX3, ‑NR3 +, ‑NO2, ‑SO3R, ‑SO2R, ‑CN, ‑CX3, ‑PO3R2, ‑OPO3R2,, and salts thereof, each R independently is H, CX3, or C1-C4 alkyl, each X independently is hydrogen or a halogen, Y is CH2, PEG, or a bond, n is an integer from 1 to 4, and PEG has the formula: –(CH2CH2O)m–(CH2)p–, where p is an integer from 1 to 5 and m is an integer from 2 to 50. The invention also provides an immunconjugate and a composition of immunoconjugates formed from said method.