N-(2-Biphenyl-4-yl-2-oxo-ethyl)-isonicotinamide

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-(2-Biphenyl-4-yl-2-oxo-ethyl)-isonicotinamide
• 英文别名: N-(2-[1,1'-Biphenyl]-4-YL-2-oxoethyl)isonicotinamide；N-[2-oxo-2-(4-phenylphenyl)ethyl]pyridine-4-carboxamide
• 化学式: C₂₀H₁₆N₂O₂
• 分子量: 316.359
• InChiKey: QEHQCQUZRAGRKS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  59.1
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-(2-Biphenyl-4-yl-2-oxo-ethyl)-isonicotinamide 在 硫酸 作用下， 生成 4-[5-(Biphenyl-4-yl)-1,3-oxazol-2-yl]pyridine
  参考文献：
  名称：

  Combinatorial discovery of novel fluorescent dyes based on Dapoxyl™

  摘要：

  We have developed a combinatorial method for the fast and effective synthesis of a library based on a known fluorescent dye, Dapoxyl(TM) using parallel solution-phase chemistry. By screening the 140 new compounds using fluorescence-based assays, we identified three new fluorescent dyes with novel properties. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)00999-1
• 作为产物：
  描述：

  异烟酸 、 p-Phenylphenacylamin 在 N,N'-二异丙基碳二亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 N-(2-Biphenyl-4-yl-2-oxo-ethyl)-isonicotinamide
  参考文献：
  名称：

  Combinatorial discovery of novel fluorescent dyes based on Dapoxyl™

  摘要：

  We have developed a combinatorial method for the fast and effective synthesis of a library based on a known fluorescent dye, Dapoxyl(TM) using parallel solution-phase chemistry. By screening the 140 new compounds using fluorescence-based assays, we identified three new fluorescent dyes with novel properties. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)00999-1