12-(β-D-glucopyranosyl)-12,13-dihydro-5H-pyrido[2,3-b]pyrido[3',2':4,5]pyrrolo[3,2-g]pyrrolo[3,4-e]indole-5,7(6H)-dione | 480434-61-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 12-(β-D-glucopyranosyl)-12,13-dihydro-5H-pyrido[2,3-b]pyrido[3',2':4,5]pyrrolo[3,2-g]pyrrolo[3,4-e]indole-5,7(6H)-dione
• 英文别名: 12-(beta-d-Glucopyranosyl)-12,13-dihydro-5h-pyrido[2,3-b]-pyrido[3',2':4,5]pyrrolo[3,2-g]pyrrolo[3,4-e]indole-5,7(6h)-dione；3-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,5,13,21,23-pentazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione
• CAS: 480434-61-5
• 化学式: C₂₄H₁₉N₅O₇
• 分子量: 489.444
• InChiKey: XRFQMXDZWCRLGE-MNMRIVKUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  36
• 可旋转键数：
  2
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  183
• 氢给体数：
  6
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  对甲苯磺酰氯 、 12-(β-D-glucopyranosyl)-12,13-dihydro-5H-pyrido[2,3-b]pyrido[3',2':4,5]pyrrolo[3,2-g]pyrrolo[3,4-e]indole-5,7(6H)-dione 在 potassium carbonate 作用下， 以 四氢呋喃 为溶剂， 反应 48.0h， 生成 12-(2-O-tosyl-β-D-glucopyranosyl)-12,13-dihydro-5H-pyrido[2,3-b]pyrido[3',2':4,5]pyrrolo[3,2-g]pyrrolo[3,4-e]indole-5,7(6H)-dione
  参考文献：
  名称：

  Pyrido-pyrido-pyrrolo pyrrolo-indole and pyrido-pyrrolo pyrrolo carbazole derivatives, method for the production thereof and pharmaceutical compositions containing said derivatives

  摘要：

  式(I)的化合物：其中：W1和W2与它们连接的碳原子一起表示苯基或吡啶基，且W1或W2中至少一个表示吡啶基，R1和R2分别表示如描述中所定义的U-V式的基团，X和X1分别表示氢原子或羟基、烷氧基、巯基或烷硫基，Y和Y1分别表示氢原子，或X和Y、X1和Y1连同携带它们的碳原子表示羰基或硫代羰基，R4和R5如描述中所定义，Q1、Q2表示氢原子，或Q1和Q2连同携带它们的碳原子形成芳香键。药物。

  公开号：

  US20040152721A1
• 作为产物：
  描述：

  6-[(benzyloxy)methyl]-12-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-12,13-dihydro-5H-pyrido[2,3-b]pyrido[3',2':4,5]pyrrolo[3,2-g]pyrrolo[3,4-e]indole-5,7(6H)-dione 在 palladium on activated charcoal ammonium hydroxide 、 氢气 作用下， 以 甲醇 、 水 、 乙酸乙酯 为溶剂， 40.0 ℃ 、100.0 kPa 条件下， 反应 45.0h， 生成 12-(β-D-glucopyranosyl)-12,13-dihydro-5H-pyrido[2,3-b]pyrido[3',2':4,5]pyrrolo[3,2-g]pyrrolo[3,4-e]indole-5,7(6H)-dione
  参考文献：
  名称：

  Syntheses and antiproliferative activities of rebeccamycin analogues bearing two 7-azaindole moieties

  摘要：

  As a part of structure activity relationship studies on rebeccamycin analogues, compounds containing two aza-indole moieties were synthesized bearing either a methyl group or a hydrogen atom on the imide nitrogen. The azaindole substructures were expected to enhance the cytotoxicity toward tumor cell lines through stronger hydrogen bonding with the target enzyme(s). The cytotoxicities of compounds 8, 10 and 19 against a panel of tumor cell lines were examined and compared with those of rebeccamycin, dechlorinated rebeccamycin 2 and N-methylated analogue A. Their effect on the L1210 cell cycle was also evaluated. Compound 19, having an imide NH function had the strongest cytotoxicity towards L1210 cells and induced the largest accumulation of cells in the G2 + M phases of the cell cycle. In contrast to their non-aza analogues, which were cytotoxic for all the cell lines tested, diaza compounds 10 and 19 showed selectivity for some cell lines. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(02)00532-1

文献信息

• US7001906B2
  申请人：——

  公开号：US7001906B2

  公开（公告）日：2006-02-21