8-(4-Chlorophenyl)-11,11-dimethyl-5,9-dioxo-6,8,10,12-tetrahydroquinolino[1,2-a]quinazoline-7-carbonitrile | 960236-57-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 8-(4-Chlorophenyl)-11,11-dimethyl-5,9-dioxo-6,8,10,12-tetrahydroquinolino[1,2-a]quinazoline-7-carbonitrile
• CAS: 960236-57-1
• 化学式: C₂₅H₂₀ClN₃O₂
• 分子量: 429.906
• InChiKey: RPIWUCSETBSCAN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  31
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  73.2
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  5,5-二甲基-1,3-环己二酮 在 CuO nanoparticles 作用下， 以 水 为溶剂， 反应 1.33h， 生成 8-(4-Chlorophenyl)-11,11-dimethyl-5,9-dioxo-6,8,10,12-tetrahydroquinolino[1,2-a]quinazoline-7-carbonitrile
  参考文献：
  名称：

  Nanocrystalline Copper(II) Oxide–Catalyzed One-Pot Synthesis of Imidazo[1,2-a]quinoline and Quinolino[1,2-a]quinazoline Derivatives via a Three-Component Condensation

  摘要：

  A simple, efficient, and practical procedure for the synthesis of imidazo[1,2-a]quinoline and quinolino[1,2-a]quinazoline derivatives using CuO nanoparticles as a novel catalyst in excellent yields is described. The catalyst can be recovered conveniently and reused at least four times without any loss of activity.

  DOI：

  10.1080/00397910903576693

文献信息

• Nanocrystalline Copper(II) Oxide–Catalyzed One-Pot Synthesis of Imidazo[1,2-<i>a</i>]quinoline and Quinolino[1,2-<i>a</i>]quinazoline Derivatives via a Three-Component Condensation
  作者：Seyed Javad Ahmadi、Morteza Hosseinpour、Sodeh Sadjadi

  DOI：10.1080/00397910903576693

  日期：2011.1.25

  A simple, efficient, and practical procedure for the synthesis of imidazo[1,2-a]quinoline and quinolino[1,2-a]quinazoline derivatives using CuO nanoparticles as a novel catalyst in excellent yields is described. The catalyst can be recovered conveniently and reused at least four times without any loss of activity.