tert-butyl-[[(4R,5R)-5-[(1Z,3S)-3-methoxy-3-methylhexa-1,5-dienyl]-2,2-dimethyl-1,3-dioxolan-4-yl]methoxy]-diphenylsilane | 1015481-92-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: tert-butyl-[[(4R,5R)-5-[(1Z,3S)-3-methoxy-3-methylhexa-1,5-dienyl]-2,2-dimethyl-1,3-dioxolan-4-yl]methoxy]-diphenylsilane
• CAS: 1015481-92-1
• 化学式: C₃₀H₄₂O₄Si
• 分子量: 494.747
• InChiKey: DLBUTWDGLLFCRE-OOGQOLOASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.62
• 重原子数：
  35
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  36.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  tert-butyl-[[(4R,5R)-5-[(1Z,3S)-3-methoxy-3-methylhexa-1,5-dienyl]-2,2-dimethyl-1,3-dioxolan-4-yl]methoxy]-diphenylsilane 在 palladium on activated charcoal 氢气 作用下， 以 甲苯 为溶剂， 以89%的产率得到
  参考文献：
  名称：

  Total synthesis of A-315675 based on the cascade Overman rearrangement

  摘要：

  The chiral and stereoselective total synthesis of A-315675 1, an antiinfluenza agent, is described. The vicinal diamino moiety in 1 was stereoselectively constructed by the cascade Overman rearrangement of a vicinal allylic-homoallylic diol derived from D-tartrate. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.12.080
• 作为产物：
  描述：

  、 碘甲烷 以 N,N-二甲基甲酰胺 为溶剂， 以93%的产率得到tert-butyl-[[(4R,5R)-5-[(1Z,3S)-3-methoxy-3-methylhexa-1,5-dienyl]-2,2-dimethyl-1,3-dioxolan-4-yl]methoxy]-diphenylsilane
  参考文献：
  名称：

  Total synthesis of A-315675 based on the cascade Overman rearrangement

  摘要：

  The chiral and stereoselective total synthesis of A-315675 1, an antiinfluenza agent, is described. The vicinal diamino moiety in 1 was stereoselectively constructed by the cascade Overman rearrangement of a vicinal allylic-homoallylic diol derived from D-tartrate. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.12.080

文献信息

• Total synthesis of A-315675 based on the cascade Overman rearrangement
  作者：Takayuki Momose、Naoto Hama、Chiharu Higashino、Hideyuki Sato、Noritaka Chida

  DOI：10.1016/j.tetlet.2007.12.080

  日期：2008.2

  The chiral and stereoselective total synthesis of A-315675 1, an antiinfluenza agent, is described. The vicinal diamino moiety in 1 was stereoselectively constructed by the cascade Overman rearrangement of a vicinal allylic-homoallylic diol derived from D-tartrate. (c) 2007 Elsevier Ltd. All rights reserved.