N-[(Z)-(3-benzyl-4-oxo-1,3-thiazolidin-2-ylidene)amino]quinoline-2-carboxamide | 1125771-80-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-[(Z)-(3-benzyl-4-oxo-1,3-thiazolidin-2-ylidene)amino]quinoline-2-carboxamide
• CAS: 1125771-80-3
• 化学式: C₂₀H₁₆N₄O₂S
• 分子量: 376.439
• InChiKey: UIPQBKYHVUNZAG-ATJXCDBQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  100
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  N-benzyl-2-(quinolin-2-ylcarbonyl)hydrazincarbothioamide 、 溴乙酸乙酯 在 sodium acetate 作用下， 以 乙醇 为溶剂， 反应 3.0h， 以80%的产率得到N-[(Z)-(3-benzyl-4-oxo-1,3-thiazolidin-2-ylidene)amino]quinoline-2-carboxamide
  参考文献：
  名称：

  Synthesis and Reactions of Some New Quinoline Thiosemicarbazide Derivatives of Potential Biological Activity

  摘要：

  Quinoline-2-carbohydrazide (3) was reacted with aryl or alkyl isothiocyanates to give the corresponding quinoline thiosemicarbazides (4a-e). Cyclization of the substituted thiosemicarbazides with sodium hydroxide led to the formation of 5-(quinolin-2-yl)-2H-1, 2, 4-triazole-3(4H)-thiones (5a-e). Desulfurization of thiosemicarbazides by mercuric oxide gave 5-(quinolin-2-yl)-1, 3, 4-oxadiazol- 2-amines (6a-e). Treatment of thiosemicarbazides with ethyl bromoacetate or -bromopropionic acid yielded (Z)-N'-(3-substituted thiazolidin-4-oxo-2-ylidene) quinoline-2-carbohydrazides (7a-d), (8a-d), respectively. Treatment of thiosemicarbazides with chloroacetone furnished (Z)-N'-(4-methyl-3-substituted-thiazol-2(3H)-ylidene) quinoline-2-carbohydrazides (9a-d). Furthermore, the reaction of thiosemicarbazides with phosphorus oxychloride gave N-substituted-5-(quinolin-2-yl)-1,3,4-thiadiazol-2-amines (10a-e). All newly synthesized compounds were tested and evaluated for antimicrobial activity.

  DOI：

  10.1080/10426500701641304

文献信息

• Synthesis and Reactions of Some New Quinoline Thiosemicarbazide Derivatives of Potential Biological Activity
  作者：E. M. Keshk、S. I. El-Desoky、M. A. A. Hammouda、A. H. Abdel-Rahman、A. G. Hegazi

  DOI：10.1080/10426500701641304

  日期：2008.5.14

  Quinoline-2-carbohydrazide (3) was reacted with aryl or alkyl isothiocyanates to give the corresponding quinoline thiosemicarbazides (4a-e). Cyclization of the substituted thiosemicarbazides with sodium hydroxide led to the formation of 5-(quinolin-2-yl)-2H-1, 2, 4-triazole-3(4H)-thiones (5a-e). Desulfurization of thiosemicarbazides by mercuric oxide gave 5-(quinolin-2-yl)-1, 3, 4-oxadiazol- 2-amines (6a-e). Treatment of thiosemicarbazides with ethyl bromoacetate or -bromopropionic acid yielded (Z)-N'-(3-substituted thiazolidin-4-oxo-2-ylidene) quinoline-2-carbohydrazides (7a-d), (8a-d), respectively. Treatment of thiosemicarbazides with chloroacetone furnished (Z)-N'-(4-methyl-3-substituted-thiazol-2(3H)-ylidene) quinoline-2-carbohydrazides (9a-d). Furthermore, the reaction of thiosemicarbazides with phosphorus oxychloride gave N-substituted-5-(quinolin-2-yl)-1,3,4-thiadiazol-2-amines (10a-e). All newly synthesized compounds were tested and evaluated for antimicrobial activity.