beta-D-半乳糖基胺 | 74867-91-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: beta-D-半乳糖基胺
• 英文名称: glucopyranosylamine
• 英文别名: 2-Amino-6-(hydroxymethyl)oxane-3,4,5-triol
• CAS: 74867-91-7；6318-23-6
• 化学式: C₆H₁₃NO₅
• 分子量: 179.173
• InChiKey: WCWOEQFAYSXBRK-UHFFFAOYSA-N

物化性质

• 熔点：
  128-133°C
• 沸点：
  416.4±45.0 °C(Predicted)
• 密度：
  1.563±0.06 g/cm3(Predicted)
• 溶解度：
  溶于甲醇、水

计算性质

• 辛醇/水分配系数(LogP)：
  -2.8
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  116
• 氢给体数：
  5
• 氢受体数：
  6

安全信息

• 海关编码：
  2932999099

反应信息

• 作为反应物：
  描述：

  beta-D-半乳糖基胺 、 在 三乙胺 作用下， 以 水 、 N,N-二甲基甲酰胺 为溶剂， 以98 %的产率得到
  参考文献：
  名称：

  通过嵌入潜在二硫化物对噻吩基共轭聚合物进行高效、模块化的生物功能化

  摘要：

  生物功能化的共轭聚合物（即携带酶、抗体和核酸）对于许多生物应用来说非常有意义，但在生物相容性条件下共轭聚合物的有效生物功能化具有挑战性。我们报告了一种简单的策略，通过嵌入潜在二硫键官能团的硫醇-烯化学来制造生物功能化共轭聚合物。这是通过含环状二硫化物的二氧噻吩的设计实现的，该二氧噻吩可以通过酸催化的链增长聚合整合到一系列共轭聚合物中。这种具有葡萄糖氧化酶的生物功能化聚合物的实用性已经在有机电化学晶体管中用于葡萄糖的选择性传感中进行了检验。这项工作为创建生物功能有机半导体提供了场所。

  DOI：

  10.1021/jacs.3c10321

文献信息

• CATIONIC LIPIDS, METHODS FOR PREPARING THE SAME, AND DELIVERY SYSTEMS HAVING ABILITY TO TRANSITION INTO CELLS COMPRISING THE SAME
  申请人：Park Myung-Ok

  公开号：US20130123485A1

  公开（公告）日：2013-05-16

  The present invention provides cationic lipids, methods for preparing the same, and delivery systems comprising the same. The present invention can provide cationic lipids which enhance the efficiency of intracellular or in vivo delivery of multiple-anionic target compounds such as drugs, anticancer agents, nucleic acids, etc., have no intracellular toxicity, but show increased stability, methods for preparing the same, and delivery systems comprising the same.

  本发明提供了阳离子脂质、其制备方法以及包含该脂质的传递系统。本发明可以提供增强多阴离子靶向化合物（如药物、抗癌剂、核酸等）在细胞内或体内传递效率的阳离子脂质，不具有细胞内毒性，但表现出增加的稳定性，以及其制备方法和包含该脂质的传递系统。
• SYNTHETIC CATALYSTS FOR CARBOHYDRATE PROCESSING
  申请人：Iowa State University Research Foundation, Inc.

  公开号：US20220016612A1

  公开（公告）日：2022-01-20

  The disclosure relates to molecularly-imprinted cross-linked micelles that can selectively hydrolyze carbohydrates.

  该披露涉及分子印迹交联微胶束，可以选择性地水解碳水化合物。
• Combination of pentacyclic triterpenes and hydroxytyrosol and derivatives thereof
  申请人：Natac Biotech, S.L.

  公开号：EP2813221A1

  公开（公告）日：2014-12-17

  The present invention is related to a product comprising a pentacyclic triterpene and hydroxytyrosol or derivatives thereof, uses, and pharmaceutical composition thereof.

  本发明涉及一种包含五环三萜和羟基酪醇或其衍生物的产品、用途及其药物组合物。
• BIO-INSPIRED POLYMERS FOR USE AS SYNTHETIC MUCINS
  申请人：Massachusetts Institute of Technology

  公开号：US20190117682A1

  公开（公告）日：2019-04-25

  Provided are glycosylated polymers that derive from carboxymethyl cellulose and may function as synthetic mucins. The carboxymethyl cellulose backbone of the polymers provide structures amenable to glycosylation by amidation of the carboxyl groups with glycosylamine moieties. The polymers can inhibit microbial virulence and may be useful in a variety of applications, such as treating microbial infections, preventing biofilm formation, and improving gastrointestinal health. Thus, provided are compositions (e.g., pharmaceutical, prebiotic, nutraceutical, food product) comprising the polymers, lubricants comprising the polymers, coatings comprising the polymers, methods of inhibiting microbial virulence, methods of inhibiting and/or preventing biofilm formation, methods of treating and/or preventing infection (e.g., bacterial, protozoan, or fungal infection). Also provided are methods of preparing the polymers described herein.
• COMPOSITIONS AND METHODS FOR DELIVERY OF NUCLEIC ACID TO PLANT CELLS
  申请人：The University of Bristol

  公开号：US20200392525A1

  公开（公告）日：2020-12-17

  The present proposals relate to the delivery of nucleic acids to plant cells and particularly, although not exclusively, to bioengineering of plants by delivery of DNA and expression in a host plant. The proposals also relates to enhancement of photosynthesis in plants and to algaecidal compositions. In these proposals, the CND compound has the formula: CND-[(L) y -X] in which: CND is a carbon nanodot having a diameter in the range 0.5-20 nm; L is a linker selected from C 1-20 alkylene, or C 1-20 alkenylene groups optionally including 1-5 heteroatoms selected from —O—, —N(H)—, and —S—; X is selected from: a) PEG-(NR 2 ) q , in which each R is independently H or C 1-6 alkyl and the integer q is 0 or 1 and in which the PEG-(NR2)q is optionally associated with a nucleic acid; b) a sugar moiety; and c) an NR2 group, in which each R is independently H or C 1-6 alkyl wherein PEG is a polyethylene glycol having a weight average molecular weight (Mw) greater than 200 the integer y is 0 or 1; wherein when y is 1, each of the CND and X moieties is attached to the L group either directly or via an amide bond; and z is an integer greater than or equal to 1.