(+/-)-4-(3-chlorophenyl)-6-[hydroxy(1-methyl-1H-imidazol-5-yl)-2-thiazolylmethyl]-1-methyl-2(1H)-quinolinone | 406216-75-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (+/-)-4-(3-chlorophenyl)-6-[hydroxy(1-methyl-1H-imidazol-5-yl)-2-thiazolylmethyl]-1-methyl-2(1H)-quinolinone
• 英文别名: 4-(3-Chlorophenyl)-6-[hydroxy-(3-methylimidazol-4-yl)-(1,3-thiazol-2-yl)methyl]-1-methylquinolin-2-one
• CAS: 406216-75-9
• 化学式: C₂₄H₁₉ClN₄O₂S
• 分子量: 462.959
• InChiKey: RTIIWSLYROAYKY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  32
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  99.5
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4-(3-chlorophenyl)-6-[hydroxy(1-methyl-1H-imidazol-5-yl)-2-thiazolylmethyl]-2(1H)-quinolinone 生成 (+-)-4-(3-chlorophenyl)-6-[methoxy(1-methyl-1-imidazol-5-yl)-2-thia zolylmethyl]-1-methyl-2(1H)-quinolinone ethanedioate 、 (+/-)-4-(3-chlorophenyl)-6-[hydroxy(1-methyl-1H-imidazol-5-yl)-2-thiazolylmethyl]-1-methyl-2(1H)-quinolinone
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• Farnesyl transferase inhibiting 6-heterocyclylmethyl quinolinone derivatives
  申请人：——

  公开号：US20030199547A1

  公开（公告）日：2003-10-23

  This invention comprises the novel compounds of formula (I) 1 wherein r, t, y 1 —y 2 , R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 have defined meanings, having farnesyl transferase inhibiting activity; their preparation, compositions containing them and their use as a medicine.

  这项发明涉及具有法尼醇转移酶抑制活性的新型化合物，其化学式为(I)1，其中r、t、y1—y2、R1、R2、R3、R4、R5、R6和R7具有定义的含义；它们的制备、含有它们的组合物以及它们作为药物的用途。
• FARNESYL TRANSFERASE INHIBITING 6-HETEROCYCLYLMETHYL QUINOLINONE DERIVATIVES
  申请人：JANSSEN PHARMACEUTICA N.V.

  公开号：EP1322644A1

  公开（公告）日：2003-07-02
• US7067531B2
  申请人：——

  公开号：US7067531B2

  公开（公告）日：2006-06-27
• [EN] FARNESYL TRANSFERASE INHIBITING 6-HETEROCYCLYLMETHYL QUINOLINONE DERIVATIVES<br/>[FR] DERIVES DE 6-HETEROCYCLYLMETHYL QUINOLINONE INHIBANT LA FARNESYL TRANSFERASE
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2002024687A1

  公开（公告）日：2002-03-28

  This invention comprises the novel compounds of formula (I) wherein r, t, Y?1-Y2, R1, R2, R3, R4, R5, R6 and R7¿ have defined meanings, having farnesyl transferase inhibiting activity; their preparation, compositions containing them and their use as a medicine.