4-(benzyloxy)-2-chloro-5-methylpyrimidine | 1366240-68-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-(benzyloxy)-2-chloro-5-methylpyrimidine
• 英文别名: 2-Chloro-5-methyl-4-phenylmethoxypyrimidine；2-chloro-5-methyl-4-phenylmethoxypyrimidine
• CAS: 1366240-68-7
• 化学式: C₁₂H₁₁ClN₂O
• 分子量: 234.685
• InChiKey: ARVKTISTUPUBEU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  35
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(benzyloxy)-2-chloro-5-methylpyrimidine 在 二苯甲酮亚胺 、 Pd(cin)Cl-IPent^An 、 sodium t-butanolate 作用下， 以 1,4-二氧六环 为溶剂， 以72 %的产率得到4-(benzyloxy)-5-methylpyrimidin-2-amine
  参考文献：
  名称：

  [EN] PTPN2 INHIBITORS
  [FR] INHIBITEURS DE PTPN2

  摘要：

  The present invention is generally directed to inhibitors of protein tyrosine phosphatase enzymes (PTPN1 and/or PTPN2) useful in the treatment of diseases and disorders modulated by said enzymes and having the Formula (I). Further disclosed a method of treating a disease or disorder associated with PTPN1/PTPN2, comprising of administering to a subject a compound or a pharmaceutical composition.

  公开号：

  WO2023220572A1
• 作为产物：
  描述：

  2,4-二氯-5-甲基嘧啶 、 苯甲醇 在 caesium carbonate 作用下， 以 乙腈 为溶剂， 以93 %的产率得到4-(benzyloxy)-2-chloro-5-methylpyrimidine
  参考文献：
  名称：

  [EN] PTPN2 INHIBITORS
  [FR] INHIBITEURS DE PTPN2

  摘要：

  The present invention is generally directed to inhibitors of protein tyrosine phosphatase enzymes (PTPN1 and/or PTPN2) useful in the treatment of diseases and disorders modulated by said enzymes and having the Formula (I). Further disclosed a method of treating a disease or disorder associated with PTPN1/PTPN2, comprising of administering to a subject a compound or a pharmaceutical composition.

  公开号：

  WO2023220572A1

文献信息

• [EN] 2-(3,5-DISUBSTITUTEDPHENYL)PYRIMIDIN-4(3H)-ONE DERIVATIVES<br/>[FR] DÉRIVÉS DE 2-(3,5-DISUBSTITUTEDPHENYL)PYRIMIDIN-4(3H)-ONE
  申请人：PFIZER

  公开号：WO2011158149A1

  公开（公告）日：2011-12-22

  O N NH R3 R2 O R1 168 ABSTRACT The present invention provides a 2-(3,5-disubstitutedphenyl)pyrimidin- 4(3H)-one compound of Formula (I) 5 (I) or a pharmaceutically acceptable salt thereof wherein R 1, R2 and R3 are as defined herein. The compounds of Formula (I) have been found to act as glucokinase activators. Consequently, the compounds of Formula (I) and 10 the pharmaceutical compositions thereof are useful for the treatment of diseases, disorders, or conditions mediated by glucokinase.

  本发明提供了一种Formula (I)的2-(3,5-二取代苯基)嘧啶-4(3H)-酮化合物或其药学上可接受的盐，其中R1、R2和R3如本文所定义。已发现Formula (I)的化合物可作为葡萄糖激酶激活剂。因此，Formula (I)的化合物及其药物组成物对于治疗由葡萄糖激酶介导的疾病、紊乱或症状是有用的。
• [EN] PTPN2 INHIBITORS<br/>[FR] INHIBITEURS DE PTPN2
  申请人：[en]NESS THERAPEUTICS, INC.

  公开号：WO2023220572A1

  公开（公告）日：2023-11-16

  The present invention is generally directed to inhibitors of protein tyrosine phosphatase enzymes (PTPN1 and/or PTPN2) useful in the treatment of diseases and disorders modulated by said enzymes and having the Formula (I). Further disclosed a method of treating a disease or disorder associated with PTPN1/PTPN2, comprising of administering to a subject a compound or a pharmaceutical composition.