3-methyl-bicyclo[13.1.0]hexadecan-5-one | 942117-24-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-methyl-bicyclo[13.1.0]hexadecan-5-one
• 英文别名: 3-Methylbicyclo[13.1.0]hexadecan-5-one
• CAS: 942117-24-0
• 化学式: C₁₇H₃₀O
• 分子量: 250.425
• InChiKey: JRSHICPBEJSBKV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  18
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  二碘甲烷 、 (Z)-5-muscenone 在 diethylzinc 作用下， 以 甲基叔丁基醚 、 甲苯 为溶剂， 以39.3%的产率得到3-methyl-bicyclo[13.1.0]hexadecan-5-one
  参考文献：
  名称：

  Cyclopropanated macrocyclic ketone

  摘要：

  公开号：

  EP1712538B1

文献信息

• Cyclopropanated macrocyclic ketones and lactones
  申请人：Narula P.S. Anubhav

  公开号：US20060234883A1

  公开（公告）日：2006-10-19

  The present invention is directed to novel cyclopropanated macrocyclic ketone and lactone compounds of the general formula wherein X is an atom or a functional group selected from the group consisting of 0, N, S, CH, or CH 2 ; wherein Y is a straight or branched hydrocarbon moiety consisting of 1 to 20 carbon atoms; wherein W is a straight or branched hydrocarbon moiety of consisting of 1 to 20 carbon atoms; and wherein O is an oxygen atom; and the use of these novel compounds in creating fragrances, and scents in items such as perfumes, colognes and personal care products.

  本发明涉及一种新颖的环丙基化的大环酮和内酯化合物，其一般化学式为其中X是从0、N、S、CH或CH2组成的原子或官能团；Y是由1至20个碳原子组成的直链或支链碳氢基团；W是由1至20个碳原子组成的直链或支链碳氢基团；O是氧原子；以及这些新颖化合物在制造香水、古龙香水和个人护理产品等物品中的用途。
• [EN] CYCLOPROPANATION OF SUBSTITUTED ALKENES<br/>[FR] CYCLOPROPANATION D'ALCÈNES SUBSTITUÉS
  申请人：INT FLAVORS & FRAGRANCES INC

  公开号：WO2017024126A1

  公开（公告）日：2017-02-09

  Disclosed is a cyclopropanation process comprising the step of reacting an alkene compound having at least one carbon-carbon double bond with at least one dihaloalkane. The reaction is carried out in the presence of (i) particulate metal Zn, (ii) catalytically effective amount of particulate metal Cu or a salt thereof, (iii) at least one haloalkylsilane, and (iv) at least one solvent.

  公开了一种环丙烷化过程，包括将至少具有一个碳-碳双键的烯烃化合物与至少一种二卤代烷反应的步骤。反应在（i）粒状金属Zn，（ii）具有催化作用的粒状金属Cu或其盐，（iii）至少一种卤代烷基硅烷和（iv）至少一种溶剂的存在下进行。
• CYCLOPROPANATION OF SUBSTITUTED ALKENES
  申请人：International Flavors & Fragrances Inc.

  公开号：US20190177247A1

  公开（公告）日：2019-06-13

  Disclosed is a cyclopropanation process comprising the step of reacting an alkene compound having at least one carbon-carbon double bond with at least one dihaloalkane. The reaction is carried out in the presence of (i) particulate metal Zn, (ii) catalytically effective amount of particulate metal Cu or a salt thereof, (iii) at least one haloalkylsilane, and (iv) at least one solvent.

  公开了一种环丙烷化过程，包括将至少具有一个碳-碳双键的烯烃化合物与至少一种二卤代烷反应的步骤。在（i）颗粒状金属锌，（ii）颗粒状金属铜或其盐的催化剂有效量，（iii）至少一种卤代烷基硅烷和（iv）至少一种溶剂的存在下进行反应。
• Cyclopropanated Macrocyclic Ketones and Lactones
  申请人：Narula Anubhav P.S.

  公开号：US20090087402A1

  公开（公告）日：2009-04-02

  The present invention is directed to novel cyclopropanated macrocyclic ketone and lactone compounds of the general formula: wherein X is an atom or a functional group selected from the group consisting of O, N, S, R—CH, and CH2; wherein R is a C1-C3 alkyl group; wherein Y and W independently represent is a linear or branched alkyl or alkenyl group, optionally substituted, consisting of less than 10 and preferably less than 7 carbon atoms; and wherein O is an oxygen atom, and the use of these novel compounds in creating fragrances and scents in items such as perfumes, colognes, and personal care products.

  本发明涉及新的环丙基化的大环酮和内酯化合物，其一般式如下：其中X为从O、N、S、R—CH和CH2组成的群体中选取的原子或官能团；其中R为C1-C3烷基；其中Y和W分别表示线性或支链烷基或烯基，可选地取代，由少于10个碳原子组成，优选少于7个碳原子；并且O为氧原子。这些新化合物在创造香水、古龙香水和个人护理产品等物品的香味和气味方面有用。
• Cyclopropanated macrocyclic lactone
  申请人：International Flavors & Fragrances Inc.

  公开号：EP2301927A1

  公开（公告）日：2011-03-30

  The present invention is directed to a cyclopropanated macrocyclic lactone compound of the formula and the use of this compound in creating fragrances, and scents in items such as perfumes, colognes and personal care products.

  本发明涉及一种式如下的环丙烷化大环内酯化合物 以及该化合物在香水、古龙水和个人护理产品等产品中制造香料和香味的用途。