LG2-81 | 1011472-13-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: LG2-81
• 英文别名: 1-[3-[8-(4-Morpholin-4-ylanilino)imidazo[1,2-a]pyrazin-3-yl]phenyl]ethanone
• CAS: 1011472-13-1
• 化学式: C₂₄H₂₃N₅O₂
• 分子量: 413.479
• InChiKey: YKKJHPHHEMQARK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  31
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  71.8
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  LG2-77 、 3-乙酰基苯硼酸频那醇酯 在 四(三苯基膦)钯 potassium carbonate 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 0.17h， 以48%的产率得到LG2-81
  参考文献：
  名称：

  WO2008/30795

  摘要：

  公开号：

文献信息

• COMPOSITIONS AND METHODS FOR INHIBITION OF TYROSINE KINASES
  申请人：Bornmann William

  公开号：US20100144743A1

  公开（公告）日：2010-06-10

  Compositions for inhibiting the catalytic activity of tyrosine kinases comprising compounds represented by Formulas (I), (II), and (III). Methods for treating proliferative diseases comprising administering a therapeutically effective amount of the above compositions.

  抑制酪氨酸激酶催化活性的组合物包括由公式（I）、（II）和（III）所表示的化合物。治疗增殖性疾病的方法包括给予上述组合物的治疗有效量。
• Kinase inhibitors for preventing or treating pathogen infection and method of use thereof
  申请人：Emory University

  公开号：EP2364702A2

  公开（公告）日：2011-09-14

  A composition is provided which comprises one or more Kinase inhibitors for use for preventing or treating a pathogenic infection caused by a broad array of pathogens in a patient in need thereof.

  本发明提供了一种组合物，其中包含一种或多种激酶抑制剂，用于预防或治疗由多种病原体引起的病原体感染。
• Kinase Inhibitors for Preventing or Treating Pathogen Infection and Method of Use Thereof
  申请人：Emory University

  公开号：EP2471529A2

  公开（公告）日：2012-07-04

  A composition is provided which comprises one or more Kinase inhibitors for use for preventing or treating a pathogenic infection caused by a broad array of pathogens in a patient in need thereof.

  本发明提供了一种组合物，其中包含一种或多种激酶抑制剂，用于预防或治疗由多种病原体引起的病原体感染。
• KINASE INHIBITORS FOR PREVENTING OR TREATING PATHOGEN INFECTION AND METHOD OF USE THEREOF
  申请人：Kalman Daniel

  公开号：US20120302565A1

  公开（公告）日：2012-11-29

  The present invention provides compositions and methods of use thereof to prevent and/or treat pathogenic infection. In particular, the present invention provides the use of kinase inhibitors to inhibit kinases that involve in pathogen-host cell interactions that are associated with or cause pathogenic infections, therefore, to effectively prevent and/or treat pathogenic infections with far less likely to engender resistance as compared to conventional antibiotics and anti-viral drugs. The present invention further provides the use of kinase inhibitors for the treatment of acute pathogenic infections for a short period of time to avoid toxicities that may caused by long term use of these kinase inhibitors.
• US8268809B2
  申请人：——

  公开号：US8268809B2

  公开（公告）日：2012-09-18