LG2-77 | 1011472-12-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: LG2-77
• 英文别名: 3-bromo-N-(4-morpholin-4-ylphenyl)imidazo[1,2-a]pyrazin-8-amine
• CAS: 1011472-12-0
• 化学式: C₁₆H₁₆BrN₅O
• 分子量: 374.24
• InChiKey: QQROMFAAITZUDV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  54.7
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  LG2-77 、 3-乙酰基苯硼酸频那醇酯 在 四(三苯基膦)钯 potassium carbonate 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 0.17h， 以48%的产率得到LG2-81
  参考文献：
  名称：

  WO2008/30795

  摘要：

  公开号：
• 作为产物：
  描述：

  4-(4-吗啉基)苯胺 、 3,5-二溴咪唑[1,2-A]吡嗪 在 N,N-二异丙基乙胺 作用下， 以 三氟乙醇 为溶剂， 反应 5.0h， 以14%的产率得到LG2-77
  参考文献：
  名称：

  WO2008/30795

  摘要：

  公开号：

文献信息

• COMPOSITIONS AND METHODS FOR INHIBITION OF TYROSINE KINASES
  申请人：Bornmann William

  公开号：US20100144743A1

  公开（公告）日：2010-06-10

  Compositions for inhibiting the catalytic activity of tyrosine kinases comprising compounds represented by Formulas (I), (II), and (III). Methods for treating proliferative diseases comprising administering a therapeutically effective amount of the above compositions.

  抑制酪氨酸激酶催化活性的组合物包括由公式（I）、（II）和（III）所表示的化合物。治疗增殖性疾病的方法包括给予上述组合物的治疗有效量。
• Kinase inhibitors for preventing or treating pathogen infection and method of use thereof
  申请人：Emory University

  公开号：EP2364702A2

  公开（公告）日：2011-09-14

  A composition is provided which comprises one or more Kinase inhibitors for use for preventing or treating a pathogenic infection caused by a broad array of pathogens in a patient in need thereof.

  本发明提供了一种组合物，其中包含一种或多种激酶抑制剂，用于预防或治疗由多种病原体引起的病原体感染。
• Kinase Inhibitors for Preventing or Treating Pathogen Infection and Method of Use Thereof
  申请人：Emory University

  公开号：EP2471529A2

  公开（公告）日：2012-07-04

  A composition is provided which comprises one or more Kinase inhibitors for use for preventing or treating a pathogenic infection caused by a broad array of pathogens in a patient in need thereof.

  本发明提供了一种组合物，其中包含一种或多种激酶抑制剂，用于预防或治疗由多种病原体引起的病原体感染。
• KINASE INHIBITORS FOR PREVENTING OR TREATING PATHOGEN INFECTION AND METHOD OF USE THEREOF
  申请人：Kalman Daniel

  公开号：US20120302565A1

  公开（公告）日：2012-11-29

  The present invention provides compositions and methods of use thereof to prevent and/or treat pathogenic infection. In particular, the present invention provides the use of kinase inhibitors to inhibit kinases that involve in pathogen-host cell interactions that are associated with or cause pathogenic infections, therefore, to effectively prevent and/or treat pathogenic infections with far less likely to engender resistance as compared to conventional antibiotics and anti-viral drugs. The present invention further provides the use of kinase inhibitors for the treatment of acute pathogenic infections for a short period of time to avoid toxicities that may caused by long term use of these kinase inhibitors.
• HETEROAROMATIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS
  申请人：PFIZER INC.

  公开号：US20170037049A1

  公开（公告）日：2017-02-09

  The present invention provides, in part, compounds of Formula (I): and pharmaceutically acceptable salts thereof; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds or salts, and their uses for treating D1-mediated (or D1-associated) disorders including, e.g., schizophrenia (e.g., its cognitive and negative symptoms), schizotypal personality disorder, cognitive impairment (e.g., cognitive impairment associated with schizophrenia, AD, PD, or pharmacotherapy therapy), ADHD, Parkinson's disease, anxiety, and depression.