1-(2-(benzyloxy)phenyl)-3-hydroxy-4-(pyridin-3-yl)butan-1-one | 1083095-04-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(2-(benzyloxy)phenyl)-3-hydroxy-4-(pyridin-3-yl)butan-1-one
• 英文别名: 3-Hydroxy-1-(2-phenylmethoxyphenyl)-4-pyridin-3-ylbutan-1-one
• CAS: 1083095-04-8
• 化学式: C₂₂H₂₁NO₃
• 分子量: 347.414
• InChiKey: AVFGQMZHVJSNMT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  26
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  59.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3-(2-Phenylmethoxyphenyl)-5-(pyridin-3-ylmethyl)-4,5-dihydro-1,2-oxazole 在 水 、 铁粉 、 氯化铵 作用下， 以 乙醇 为溶剂， 反应 6.0h， 以35%的产率得到1-(2-(benzyloxy)phenyl)-3-hydroxy-4-(pyridin-3-yl)butan-1-one
  参考文献：
  名称：

  Reduction of Δ²-Isoxazolines to β-Hydroxy Ketones with Iron and Ammonium Chloride as Reducing Agent

  摘要：

  A detailed study of a procedure for the selective reduction of Delta(2)-isoxazolines to the corresponding beta-hydroxy ketones is reported. The use of iron and ammonium chloride as the reducing agent in the presence of water results in a facile and chemoselective protocol for the preparation of beta-hydroxy ketones, including the conjugated beta-hydroxy ketones.

  DOI：

  10.1021/jo801831c

文献信息

• Reduction of Δ²-Isoxazolines to β-Hydroxy Ketones with Iron and Ammonium Chloride as Reducing Agent
  作者：Dahong Jiang、Yuanwei Chen

  DOI：10.1021/jo801831c

  日期：2008.11.21

  A detailed study of a procedure for the selective reduction of Delta(2)-isoxazolines to the corresponding beta-hydroxy ketones is reported. The use of iron and ammonium chloride as the reducing agent in the presence of water results in a facile and chemoselective protocol for the preparation of beta-hydroxy ketones, including the conjugated beta-hydroxy ketones.