7-(imidazolidin-1-ylmethyl)quinoline-8-ol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 7-(imidazolidin-1-ylmethyl)quinoline-8-ol
• 英文别名: 7-(Imidazolidin-1-ylmethyl)quinolin-8-ol
• 化学式: C₁₃H₁₅N₃O
• 分子量: 229.282
• InChiKey: AEVVSQZBOBUKBQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  48.4
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  8-羟基喹啉 、 1,3,5,7-四氮杂三环[3.3.2.2(3,7)]十二烷 以 1,4-二氧六环 为溶剂， 反应 24.0h， 以56%的产率得到7-(imidazolidin-1-ylmethyl)quinoline-8-ol
  参考文献：
  名称：

  7-(Imidazolidin-1-ylmethyl)quinolin-8-ol: An Unexpected Product from a Mannich-type Reaction in Basic Medium

  摘要：

  7-(Imldazolidin- 1 -ylmethyl)quinoline-8-ol, an N-substituted imidazolidine, was synthesized in a one-step reaction between 1,3,6,8-tetraazatricyclo[4.4.1.1(3,8)]dodecane (TATD) and 8-hydroxyquinoline. Obtaining this substance enhanced the scope of possibilities in the synthesis of unsymmetrically NN-disubstituted imidazolidines. H-1-NMR spectral studies revealed that this type of substance does not undergo ring-chain tautomerism.

  DOI：

  10.3987/com-05-10642

文献信息

• 7-(Imidazolidin-1-ylmethyl)quinolin-8-ol: An Unexpected Product from a Mannich-type Reaction in Basic Medium
  作者：Augusto Rivera、Jaime R弛s-Motta、Miguel Angel Navarro

  DOI：10.3987/com-05-10642

  日期：——

  7-(Imldazolidin- 1 -ylmethyl)quinoline-8-ol, an N-substituted imidazolidine, was synthesized in a one-step reaction between 1,3,6,8-tetraazatricyclo[4.4.1.1(3,8)]dodecane (TATD) and 8-hydroxyquinoline. Obtaining this substance enhanced the scope of possibilities in the synthesis of unsymmetrically NN-disubstituted imidazolidines. H-1-NMR spectral studies revealed that this type of substance does not undergo ring-chain tautomerism.