4-(3-(3-fluoro-4-hydroxyphenyl)-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile
中文名称
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中文别名
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英文名称
4-(3-(3-fluoro-4-hydroxyphenyl)-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile
英文别名
4-(3-(3-Fluoro-4-hydroxyphenyl)-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile；4-[3-(3-fluoro-4-hydroxyphenyl)-4,4-dimethyl-5-oxo-2-sulfanylideneimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile
CAS
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化学式
C19H13F4N3O2S
mdl
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分子量
423.391
InChiKey
ALEVEZMLPKTOBM-UHFFFAOYSA-N
BEILSTEIN
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EINECS
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物化性质
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计算性质
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ADMET
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安全信息
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SDS
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制备方法与用途
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上下游信息
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文献信息
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表征谱图
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同类化合物
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相关功能分类
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相关结构分类
计算性质
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辛醇/水分配系数(LogP)：4
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重原子数：29
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可旋转键数：2
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环数：3.0
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sp3杂化的碳原子比例：0.21
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拓扑面积：99.7
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氢给体数：1
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氢受体数：8
上下游信息
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下游产品
中文名称 英文名称 CAS号 化学式 分子量 —— 4-(3-(4-(difluoromethoxy)-3-fluorophenyl)-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile —— C20H13F6N3O2S 473.399 —— 4-(3-(3-fluoro-4-(2-hydroxyethoxy)phenyl)-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile —— C21H17F4N3O3S 467.444 —— 2-(4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluorophenoxy)acetic acid —— C21H15F4N3O4S 481.427 —— 4-(3-(4-((azetidin-3-yl)oxy)-3-fluorophenyl)-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile —— C22H18F4N4O2S 478.47 —— (R)-4-(3-(4-(2,3-dihydroxypropoxy)-3-fluorophenyl)-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile —— C22H19F4N3O4S 497.47 —— (S)-4-(3-(4-(2,3-dihydroxypropoxy)-3-fluorophenyl)-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile —— C22H19F4N3O4S 497.47 —— (S)-4-(3-(4-(2,3-dihydroxypropoxy)-3-fluorophenyl)-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile —— C22H19F4N3O4S 497.47 —— 4-(3-(4-((1,3-dihydroxypropan-2-yl)oxy)-3-fluorophenyl)-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile —— C22H19F4N3O4S 497.47 —— 2-(4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluorophenoxy)-N-methylacetamide —— C22H18F4N4O3S 494.47 —— 4-(3-(3-fluoro-4-(3-(methylsulfonyl)propoxy)phenyl)-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile —— C23H21F4N3O4S2 543.563 —— 4-(3-(3-fluoro-4-(oxiran-2-ylmethoxy)phenyl)-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile —— C22H17F4N3O3S 479.455 —— methyl 2-(4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluorophenoxy)acetate —— C22H17F4N3O4S 495.454 —— 4-(3-(3-fluoro-4-((oxetan-3-yl)oxy)phenyl)-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile —— C22H17F4N3O3S 479.455 —— 4-(3-(4-((1-aminocyclopropyl)methoxy)-3-fluorophenyl)-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile —— C23H20F4N4O2S 492.497 —— 4-(3-(4-((1-cyanocyclopropyl)methoxy)-3-fluorophenyl)-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile —— C24H18F4N4O2S 502.492 —— 4-(3-(3-fluoro-4-((piperidin-4-yl)oxy)phenyl)-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile —— C24H22F4N4O2S 506.524 —— 4-(3-(3-fluoro-4-((tetrahydrofuran-3-yl)methoxy)phenyl)-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile —— C24H21F4N3O3S 507.509 —— 4-(3-(3-fluoro-4-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile —— C24H21F4N3O3S 507.509 —— 4-(3-(3-fluoro-4-((1-methylpiperidin-4-yl)oxy)phenyl)-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile —— C25H24F4N4O2S 520.551 —— 4-(3-(3-fluoro-4-((pyrrolidin-3-yl)oxy)phenyl)-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile —— C23H20F4N4O2S 492.497 —— (S)-4-(3-(3-fluoro-4-((pyrrolidin-3-yl)oxy)phenyl)-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile —— C23H20F4N4O2S 492.497 —— 1-((4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluorophenoxy)methyl)cyclopropanecarboxylic acid —— C24H19F4N3O4S 521.492 —— (R)-4-(3-(3-fluoro-4-((tetrahydrofuran-3-yl)oxy)phenyl)-4,4-dimethyl-5-oxo-2-thi oxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile —— C23H19F4N3O3S 493.482 —— (S)-4-(3-(3-fluoro-4-((tetrahydrofuran-3-yl)oxy)phenyl)-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile —— C23H19F4N3O3S 493.482 —— 4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluorophenyl trifluoromethanesulfonate —— C20H12F7N3O4S2 555.454 —— 1-((4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluorophenoxy)methyl)-N-methylcyclopropanecarboxamide —— C25H22F4N4O3S 534.534 —— (S)-4-(3-(3-fluoro-4-((1-methylpyrrolidin-3-yl)oxy)phenyl)-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile —— C24H22F4N4O2S 506.524 —— 4-(3-(3-fluoro-4-((1-methylpyrrolidin-3-yl)oxy)phenyl)-4,4-dimethyl-5-oxo-2-thi oxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile —— C24H22F4N4O2S 506.524 —— 4-(3-(4-((2,2-dimethyl-1,3-dioxan-5-yl)oxy)-3-fluorophenyl)-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile —— C25H23F4N3O4S 537.535 —— 4-(3-(4-((1,1-dioxidotetrahydro-2H-thiopyran-4-yl)oxy)-3-fluorophenyl)-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile —— C24H21F4N3O4S2 555.574 —— 4-(3-(3-fluoro-4-((4-hydroxytetrahydrofuran-3-yl)oxy)phenyl)-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile —— C23H19F4N3O4S 509.481 —— 4-(3-(3-fluoro-4-(((3S,4S)-4-hydroxytetrahydrofuran-3-yl)oxy)phenyl)-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile —— C23H19F4N3O4S 509.481 —— ethyl 1-((4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluorophenoxy)methyl)cyclopropanecarboxylate —— C26H23F4N3O4S 549.546 —— 2-(4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluorophenoxy)benzoic acid ——