(3aRS,5RS,6aRS)-5-[3-(cyclopentyloxy)-4-methoxyphenyl]-1,3a,4,5,6,6a-hexahydro-2-pentalenecarboxylic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (3aRS,5RS,6aRS)-5-[3-(cyclopentyloxy)-4-methoxyphenyl]-1,3a,4,5,6,6a-hexahydro-2-pentalenecarboxylic acid
• 英文别名: (3aS,5S,6aS)-5-(3-cyclopentyloxy-4-methoxyphenyl)-1,3a,4,5,6,6a-hexahydropentalene-2-carboxylic acid
• 化学式: C₂₁H₂₆O₄
• 分子量: 342.435
• InChiKey: ARWWIGAWUZBEBE-OAGGEKHMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (3aRS,5RS,6aRS)-5-[3-(cyclopentyloxy)-4-methoxyphenyl]-1,3a,4,5,6,6a-hexahydro-2-pentalenecarboxylic acid 在 palladium on activated charcoal 氢气 作用下， 以 甲醇 为溶剂， 反应 4.0h， 以54%的产率得到(2R,3aS,5S,6aR)-5-(3-Cyclopentyloxy-4-methoxy-phenyl)-octahydro-pentalene-2-carboxylic acid
  参考文献：
  名称：

  Design, synthesis, and biological evaluation of new phosphodiesterase type 4 inhibitors

  摘要：

  The design, synthesis, and biological evaluation of new phosphodiesterase type 4 inhibitors, which possess new templates instead of a cyclohexane ring, are described. The mode of interaction with the enzyme is discussed based on the structure-activity relationship (SAR) data obtained for the synthesized inhibitors. Furthermore, the roles of three pharmacophores, a catechol moiety, a nitrile moiety, and acidic moieties, are discussed using in silico docking studies. More detailed biological evaluations of selected compounds are also presented. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2004.07.040
• 作为产物：
  描述：

  4-溴-2-(环戊基氧基)苯甲醚 在 palladium on activated charcoal 吡啶 、 氢氧化钾 、 正丁基锂 、 cerium(III) chloride 、 氢气 、 对甲苯磺酸 、 甲基磺酰氯 、 三乙胺 、 zinc(II) iodide 、 三氯氧磷 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 二氯甲烷 、 乙二醇 、 丙酮 为溶剂， 反应 61.5h， 生成 (3aRS,5RS,6aRS)-5-[3-(cyclopentyloxy)-4-methoxyphenyl]-1,3a,4,5,6,6a-hexahydro-2-pentalenecarboxylic acid
  参考文献：
  名称：

  Design, synthesis, and biological evaluation of new phosphodiesterase type 4 inhibitors

  摘要：

  The design, synthesis, and biological evaluation of new phosphodiesterase type 4 inhibitors, which possess new templates instead of a cyclohexane ring, are described. The mode of interaction with the enzyme is discussed based on the structure-activity relationship (SAR) data obtained for the synthesized inhibitors. Furthermore, the roles of three pharmacophores, a catechol moiety, a nitrile moiety, and acidic moieties, are discussed using in silico docking studies. More detailed biological evaluations of selected compounds are also presented. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2004.07.040

文献信息

• Design, synthesis, and biological evaluation of new phosphodiesterase type 4 inhibitors
  作者：Hiroshi Ochiai、Yoshihiko Odagaki、Tazumi Ohtani、Akiharu Ishida、Kensuke Kusumi、Katuya Kishikawa、Susumu Yamamoto、Hiroshi Takeda、Takaaki Obata、Kaoru Kobayashi、Hisao Nakai、Masaaki Toda

  DOI：10.1016/j.bmc.2004.07.040

  日期：2004.10

  The design, synthesis, and biological evaluation of new phosphodiesterase type 4 inhibitors, which possess new templates instead of a cyclohexane ring, are described. The mode of interaction with the enzyme is discussed based on the structure-activity relationship (SAR) data obtained for the synthesized inhibitors. Furthermore, the roles of three pharmacophores, a catechol moiety, a nitrile moiety, and acidic moieties, are discussed using in silico docking studies. More detailed biological evaluations of selected compounds are also presented. (C) 2004 Elsevier Ltd. All rights reserved.