Q4FA18

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Q4FA18
• 英文别名: 18-(2,3,4,5-Tetramethoxyphenyl)octadecan-1-ol
• 化学式: C₂₈H₅₀O₅
• 分子量: 466.702
• InChiKey: AXGSRKQYMMJCFM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.7
• 重原子数：
  33
• 可旋转键数：
  22
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  57.2
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2,3,4-三甲氧基苯甲醛 在 palladium on activated charcoal 哌啶 、 sodium hydroxide 、 N-溴代丁二酰亚胺(NBS) 、 四(三苯基膦)钯 、 氢气 、 间氯过氧苯甲酸 、 三氟乙酸 作用下， 以 甲醇 、 乙醇 、 二氯甲烷 、 丙酮 为溶剂， 反应 28.0h， 生成 Q4FA18
  参考文献：
  名称：

  Quinol fatty alcohols as promoters of axonal growth

  摘要：

  The synthesis of three series of quinol fatty alcohols (QFAs) and their biological activities on the promotion of axonal growth are described. Interestingly, the 15-(2,5-dimethoxyphenyl)pentadecan-1-ol, the QFA bearing 15 carbon atoms on the side chain (n=15), shows the most potent promotion of axonal growth in the presence of both permissive and non-permissive naturally occurring substrates such as Sema3A and myelin proteins. (C) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.02.041

文献信息

• Quinol fatty alcohols as promoters of axonal growth
  作者：Mazen Hanbali、Marta Vela-Ruiz、Dominique Bagnard、Bang Luu

  DOI：10.1016/j.bmcl.2006.02.041

  日期：2006.5

  The synthesis of three series of quinol fatty alcohols (QFAs) and their biological activities on the promotion of axonal growth are described. Interestingly, the 15-(2,5-dimethoxyphenyl)pentadecan-1-ol, the QFA bearing 15 carbon atoms on the side chain (n=15), shows the most potent promotion of axonal growth in the presence of both permissive and non-permissive naturally occurring substrates such as Sema3A and myelin proteins. (C) 2006 Elsevier Ltd. All rights reserved.