三甲基铟 | 3385-78-2

• 物质功能分类: 有机原料 - 有机金属类化合物 - 有机铋、钴、镨、钆、镓、铱、铼、钇、铽等
• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机过渡后金属化合物
• 中文名称: 三甲基铟
• 中文别名: 高纯三甲基铟
• 英文名称: TRIMETHYLINDIUM
• 英文别名: InMe₃；trimethylindigane
• CAS: 3385-78-2
• 化学式: C₃H₉In
• 分子量: 159.924
• InChiKey: IBEFSUTVZWZJEL-UHFFFAOYSA-N

物化性质

• 熔点：
  88°C
• 沸点：
  135.7°C
• 密度：
  1,568 g/cm3
• 闪点：
  -18°C
• 稳定性/保质期：

  遵照规定使用和储存，则不会发生分解。

计算性质

• 辛醇/水分配系数(LogP)：
  1.37
• 重原子数：
  4
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

ADMET

毒理性

• 副作用

Dermatotoxin - 皮肤烧伤。

Dermatotoxin - Skin burns.

来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

安全信息

• TSCA：
  Yes
• 危险等级：
  4.2
• 安全说明：
  S16,S43,S45,S7
• 危险类别码：
  R14,R17,R34
• 海关编码：
  2931900090
• 危险类别：
  4.2
• 危险品运输编号：
  UN 2845
• 储存条件：
  存储于阴凉干燥处。

SDS

---

Section 1: Product Identification
Chemical Name: Trimethylindium, elec. gr. (99.999%-In) PURATREM **S STEEL CYL EXTRA** **Can be ampouled**
CAS Registry Number: 3385-78-2
Formula: (CH3)3In
EINECS Number: 222-200-9
Chemical Family: metal alkyl
Synonym: Indium, trimethyl

---

Section 2: Composition and Information on Ingredients
Ingredient CAS Number Percent ACGIH (TWA) OSHA (PEL)
Title Compound 3385-78-2 100% 0.1mg/m3 (as In) no data

---

Section 3: Hazards Identification
Pyrophoric material. Ignites spontaneously on contact with air causing thermal burns. Burning solid/liquid
Emergency Overview:
clings to clothing and skin.
Primary Routes of Exposure: Inhalation, skin, eyes
Eye Contact: Dust causes severe thermal burns to eyes. Irritating fumes.
Skin Contact: Solid ignites. Hard to extinguish burning gel on the skin and clothing.
White fumes from burning solid irritating to the tissues of the nose, mucous membranes, and respiratory tract.
Inhalation:
Ingestion: Ingestion of burning solid is unlikely.
Solid is pyrophoric and bursts into flames causing severe thermal burns. Dense white smoke is irritating to
Acute Health Affects:
skin, eyes and respiratory tract.
Chronic Health Affects: No information on long-term chronic effects.
NTP: No
IARC: No
OSHA: No

---

SECTION 4: First Aid Measures
Immediately flush the eyes with copious amounts of water for at least 10-15 minutes. A victim may need
Eye Exposure:
assistance in keeping their eye lids open. Get immediate medical attention.
Wash the affected area immediately with water. Remove contaminated clothing if necessary. Seek medical
Skin Exposure:
assistance if irritation persists.
Remove the victim to fresh air. Closely monitor the victim for signs of respiratory problems, such as difficulty
Inhalation:
in breathing, coughing, wheezing, or pain. In such cases seek immediate medical assistance.
Seek medical attention immediately. Keep the victim calm. Give the victim water (only if conscious). Induce
Ingestion:
vomiting only if directed by medical personnel.

---

SECTION 5: Fire Fighting Measures
Flash Point: -1°F
Autoignition Temperature: pyrophoric
Explosion Limits: no data
Extinguishing Medium: carbon dioxide, dry powder or foam
If this product is involved in a fire, fire fighters should be equipped with a NIOSH approved positive pressure
Special Fire Fighting Procedures:
self- contained breathing apparatus and full protective clothing.
Hazardous Combustion and If involved in a fire this material may emit irritating fumes of indium oxide.
Decomposion Products:
Unusual Fire or Explosion Hazards: Pyrophoric material. Material will ignite spontaneously in contact with air.

---

SECTION 6: Accidental Release Measures
The material will ignite spontaneously in air. Burning material may release toxic fumes. Leave the area unless
Spill and Leak Procedures:
fitted with a self-contained breathing apparatus. Smother fire with dry powder. Do not use water.

---

SECTION 7: Handling and Storage
Store cold. Handle and store the material under an inert atmosphere of nitrogen or argon. Prepare for the
Handling and Storage:
possibility of fire in transfer lines and containers after use. Keep away from heat.

---

SECTION 8: Exposure Controls and Personal Protection
Eye Protection: Always wear approved safety glasses when handling a chemical substance in the laboratory.
Skin Protection: Wear protective clothing and gloves. Consult with glove manufacturer to determine the proper type of glove.
Ventilation: Handle the material in an efficient fume hood.
If ventilation is not available a respirator should be worn. The use of respirators requires a Respirator
Respirator:
Protection Program to be in compliance with 29 CFR 1910.134.
Ventilation: Handle the material in an efficient fume hood.
Additional Protection: Wear a full face shield, lab apron and suitable gloves.

---

SECTION 9: Physical and Chemical Properties
Color and Form: white xtl.
Molecular Weight: 159.92
Melting Point: 88°
Boiling Point: 136°C
Vapor Pressure: no data
Specific Gravity: 1.568
Odor: none
Solubility in Water: reacts vigorously with water

---

SECTION 10: Stability and Reactivity
Stability: heat sensitive, moisture sensitive, pyrophoric
Hazardous Polymerization: no hazardous polymerization
Conditions to Avoid: contact with air
Incompatibility: oxygen, halogens, oxidizing agents and water
Decomposition Products: carbon dioxide, carbon monoxide, indium oxide, organic fumes.

---

SECTION 11: Toxicological Information
RTECS Data: No information available in the RTECS files.
Carcinogenic Effects: no data
Mutagenic Effects: no data
Tetratogenic Effects: no data

---

SECTION 12: Ecological Information
Ecological Information: No information available

---

SECTION 13: Disposal Considerations
Disposal: Dispose of according to federal, state, and local regulations.

---

SECTION 14: Transportation
Shipping Name (CFR): Organometallic substance, Solid,Pyrophoric,Water-reactive
Hazard Class (CFR): 4.2
Additional Hazard Class (CFR): 4.3
Packaging Group (CFR): I
UN ID Number (CFR): UN# 3393
Shipping Name (IATA): Forbidden
Hazard Class (IATA): NA
Additional Hazard Class (IATA): NA
Packaging Group (IATA): NA
UN ID Number (IATA): UN# 3393

---

SECTION 15: Regulatory Information
TSCA: Not listed in the TSCA inventory
SARA (Title 313): Title compound not listed.
Second Ingredient: none

---

SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

简介

三甲基铟在常温常压下为无色透明并具有特殊臭味的升华性结晶物。它遇冷水部分水解放出甲烷气体，并能与己烷、庚烷等脂肪族饱和烃，以及甲苯、二甲苯等芳香族烃任意比例相溶。三甲基铟在空气中易自燃，并可与砷化氢（AsH3）、磷化氢（PH3）、醚类、叔胺及其它路易士碱形成稳定的络合物。

物化性质

三甲基铟能与具有活性氢的醇类和酸类进行激烈反应。它还能与甲基醚、三甲基磷烷、三甲基砷烷等物质作用，形成配位化合物，但其稳定性比镓差。光照容易引起三甲基铟分解，在长期保存时需要存放在阴凉干燥之处。

用途

三甲基铟主要用于有机合成和化学气相淀积中，并在半导体生长技术领域有着重要应用，尤其是用于处延成长过程。它作为高质量固体铟源被广泛应用于发光二极管、激光二极管、晶体管以及高性能高效率太阳能电池的生产过程中。

制备

三甲基铟可通过以下方法制备：首先，在充满惰性气体的反应釜中投入铟镁合金原料，然后在醚类溶剂存在下进行搅拌。逐步加入卤代烷，通过控制滴加速度来调控溶剂回流速度。反应完成后，先将溶剂蒸出，再减压条件下得到三甲基铟与醚的配合物，最后解配得到纯净的三甲基铟。

生产方法

以铟和镁为原料，与一氯甲烷（CH3I）反应，并经解络、分馏等纯化手段可制得高纯度的三甲基铟。

反应信息

• 作为反应物：
  描述：

  三甲基铟 以 gaseous matrix 为溶剂， 生成 indium
  参考文献：
  名称：

  来自微波流反应器的铟纳米颗粒在半导体表面的受控形成和尺寸选择沉积

  摘要：

  在微波流反应器中通过三甲基铟的热分解合成了铟纳米颗粒。通过分子束采样从气相中提取粒子，在电场中偏转并沉积在半导体表面上。通过调整偏转电压来选择沉积颗粒的尺寸。发现尺寸选择的颗粒的几何标准偏差小于 10%。沉积方法与外延生长方法兼容，并通过纳米粒子技术增强了它们的潜力。

  DOI：

  10.1063/1.2012516
• 作为产物：
  描述：

  甲基氯化镁 在 indium(III) chloride 作用下， 以 四氢呋喃 为溶剂， 生成 三甲基铟
  参考文献：
  名称：

  [EN] TETRACYCLINE COMPOUNDS FOR THE TREATMENT OF RHEUMATOID ARTHRITIS AND RELATED METHODS OF TREATMENT
  [FR] COMPOSÉS DE TÉTRACYCLINE UTILISÉS DANS LE TRAITEMENT DE LA POLYARTHRITE RHUMATOÏDE ET MÉTHODES THÉRAPEUTIQUES ASSOCIÉES

  摘要：

  本发明涉及至少部分替代四环素化合物。本发明还涉及一种治疗类风湿性关节炎的方法，包括向受试者施用本发明的四环素化合物。

  公开号：

  WO2010033939A1
• 作为试剂：
  描述：

  四氢吡咯 、 4-甲苯基异腈 在 三甲基铟 、 盐酸 作用下， 以 正己烷 、 氘代苯 为溶剂， 反应 504024.0h， 生成
  参考文献：
  名称：

  Reactions of InMe3 with isocyanides in the presence of amines: chemical and mass spectrometric evidence of unprecedented insertion into InN bonds

  摘要：

  InMe3 reacts with CNR (R=C6H4-p-OMe, C6H4-p-Me) affording the corresponding adducts Me3InCNR, which are formed even in the presence of an excess of CNR. Me3InCNR reacts with pyrrolidine to give the [Me2InC(=NR)(Pyrr)] products [Pyrr = conjugated base of pyrrolidine], which form through the insertion of CNR into the In-N-Pyrr bond. These insertion products decompose easily to give the corresponding formamidines. (C) 2001 Elsevier Science B.V. All rights reserved.

  DOI：

  10.1016/s0022-328x(01)00649-0

文献信息

• Methylindium dialkylamido compounds: mono- and bis-dialkylamides involving four- and five-co-ordinated indium(III). X-Ray crystal structures of {Me2In[N(CH2)2N(Me)CH2CH2]}2, MeIn[MeNC(CH)4N]2, and MeIn{[MeN(CH2)2NMe]InMe2}2
  作者：Atta M. Arif、Donald C. Bradley、Helen Dawes、Dario M. Frigo、Michael B. Hursthouse、Bilquis Hussain

  DOI：10.1039/dt9870002159

  日期：——

  (Me2InL)2[L = [graphic omitted]H2(1), N(C6H11)2(2), and [graphic omitted]HMe (3)] is reported. The X-ray crystal structure of (1) shows an amido-bridged dimer; all the compounds appear as dimers in the mass spectra. Variable-temperature 1H n.m.r. of (3) shows that it exists as two conformational isomers which do not interconvert at room temperature. The synthesis of MeIn[MeN[graphic omitted]]2(4) and

  报告了（Me 2 InL）2 [L ＝ [图解省略的] H 2（1），N（C 6 H 11）2（2）和[图解省略的] HMe（3）]的合成。（1）的X射线晶体结构显示有酰胺桥联的二聚体。所有化合物在质谱图中均显示为二聚体。（3）的1 H nmr的变温表明，它以两种在室温下不相互转化的构象异构体的形式存在。MeIn [MeN [graphic省略]] 2（4）和MeIn [MeN（CH 2）2 NMe] InMe 2 } 2（5）也有报道，它们的X射线晶体结构显示出方形金字塔形的双（二烷基酰胺基）金属中心。（5）还包含两个外围的扭曲的四面体铟原子。
• [EN] NEW METAL N-AMINOGUANIDINATE COMPLEXES FOR USE IN THIN FILM FABRICATION AND CATALYSIS<br/>[FR] NOUVEAUX COMPLEXES MÉTALLIQUES DE N-AMINOGUANIDINATE DESTINÉS À ÊTRE UTILISÉS DANS LA FABRICATION DE COUCHE MINCE ET EN CATALYSE
  申请人：UMICORE AG & CO KG

  公开号：WO2016083471A1

  公开（公告）日：2016-06-02

  The present patent application relates to new metal complexes having at least one N-aminoguanidinate ligand. The patent application further relates to the preparation of the new metal complexes and also to their use. The new metal complexes are especially suitable as precursors for the preparation of functional layers by means of gas-phase thin-film processes such as CVD, MO-CVD, MOVPE and ALD. Additionally, they are also suitable as catalysts for olefin hydroamination and for olefin polymerization.

  本专利申请涉及具有至少一个N-氨基胍配体的新金属配合物。该专利申请进一步涉及新金属配合物的制备以及它们的用途。这些新金属配合物特别适用于通过气相薄膜工艺（如CVD、MO-CVD、MOVPE和ALD）制备功能层的前体。此外，它们还适用于烯烃氢胺化和烯烃聚合的催化剂。
• [EN] METAL COMPLEXES WITH N-AMINOAMIDINATE LIGANDS<br/>[FR] COMPLEXES MÉTALLIQUES CONTENANT DES LIGANDS N-AMINOAMIDINATE
  申请人：UMICORE AG & CO KG

  公开号：WO2012113761A1

  公开（公告）日：2012-08-30

  The invention relates to new metal complexes having N-aminoamidinate ligands, more particularly metal complexes having Ν,Ν'-bis(dimethylamino)acetamidinate, N,N'-bis(dimethylamino)formamidinate, N-dimethylaminoacetamidinate or N-dimethylamino-N'-isopropyl-acetamidinate ligands as well as to their preparation and use. The metal complexes are characterized by a five-membered chelate ring. The metal complexes are formed with the metals from the main groups of the PTE, but also with transition-group elements such as tantalum (Ta), iron (Fe), cobalt (Co), nickel (Ni), copper (Cu) or zinc (Zn), and also with precious metals such as palladium (Pd). The complexes of the invention find use as precursors for the preparation of functional layers by means of gas-phase thin-film processes such as CVD, MO-CVD and ALD. Additionally they may be used as catalysts for olefin hydroamination and for olefin polymerization.

  该发明涉及具有N-氨基甲酸酰胺配体的新金属配合物，更具体地说，涉及具有Ν,Ν'-双(二甲氨基)乙酰胺基甲酸酰胺基、N,N'-双(二甲氨基)甲酰胺基甲酸酰胺基、N-二甲氨基乙酰胺基甲酸酰胺基或N-二甲氨基-N'-异丙基乙酰胺基甲酸酰胺基配体的金属配合物，以及它们的制备和使用。这些金属配合物的特点是具有五元螯合环。这些金属配合物与主族元素PTE的金属形成，也与过渡族元素如钽（Ta）、铁（Fe）、钴（Co）、镍（Ni）、铜（Cu）或锌（Zn）以及贵金属如钯（Pd）形成。该发明的配合物可用作通过气相薄膜工艺（如CVD、MO-CVD和ALD）制备功能层的前体。此外，它们还可用作烯烃氢胺化和烯烃聚合的催化剂。
• IMIDAZO[1,2-a]PYRAZINE DERIVATIVES AND THEIR USE FOR THE PREVENTION OR TREATMENT OF NEUROLOGICAL, PSYCHIATRIC AND METABOLIC DISORDERS AND DISEASES
  申请人：Bartolomé-Nebreda José Manuel

  公开号：US20120329792A1

  公开（公告）日：2012-12-27

  The present invention relates to novel imidazo[1,2-a]pyrazine derivatives which are inhibitors of the phosphodiesterase 10 enzyme (PDE10) and which are useful for the treatment or prevention of neurological, psychiatric and metabolic disorders in which the PDE10 enzyme is involved. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes to prepare such compounds and compositions, to the use of such compounds or pharmaceutical compositions for the prevention or treatment of neurological, psychiatric and metabolic disorders and diseases.

  本发明涉及新型咪唑并[1,2-a]吡嗪衍生物，其为磷酸二酯酶10（PDE10）的抑制剂，并且适用于治疗或预防涉及PDE10酶的神经、精神和代谢性疾病。该发明还涉及包含这类化合物的药物组合物，制备这类化合物和组合物的方法，以及利用这类化合物或药物组合物预防或治疗神经、精神和代谢性疾病和疾病。
• Triorganoindium Reagents in Rh-Catalyzed C–H Activation/C–C Cross-Coupling Reactions of 2-Arylpyridines
  作者：Ricardo Riveiros、Rubén Tato、José Pérez Sestelo、Luis Sarandeses

  DOI：10.3390/molecules23071582

  日期：——

  catalytic reactions using transition metals is an important challenge in organic chemistry in which the intermediates are related to those produced in the classical cross-coupling reactions. As part of our research program devoted to the development of metal-catalyzed reactions using indium organometallics, a protocol for the C⁻H activation and C⁻C coupling of 2-arylpyridines with triorganoindium reagents

  通过使用过渡金属的催化反应来活化C⁻H键是有机化学中的重要挑战，在有机化学中，中间体与经典交叉偶联反应中产生的中间体有关。作为我们致力于开发使用铟有机金属的金属催化反应的研究计划的一部分，据报道，在Rh（I）催化下，2-芳基吡啶与三有机铟试剂进行C⁻H活化和C⁻C偶联的方案。在优化的条件下，我们发现Me₃In和Ar₃In试剂在Rh（PPh₃）：Cl的存在下于PhCl / THF（9：1）中与2-芳基吡啶和相关化合物在120°C下反应48小时，得到中等产量的邻偶合产物。

表征谱图