氯甲基三甲基锡 | 4554-90-9

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机过渡后金属化合物
• 中文名称: 氯甲基三甲基锡
• 英文名称: (chloromethyl)trimethylstannane
• 英文别名: Chlormethyl-trimethyl-stannan；Chlormethyl-trimethyl-zinn；Chloromethyltrimethyltin；chloromethyl(trimethyl)stannane
• CAS: 4554-90-9
• 化学式: C₄H₁₁ClSn
• 分子量: 213.294
• InChiKey: UJYUUICSINMICU-UHFFFAOYSA-N

物化性质

• 沸点：
  70°C 57mm
• 密度：
  1.4893 g/cm3
• 闪点：
  39°C (102°F)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  6
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

安全信息

• TSCA：
  No
• 安全说明：
  S23,S36/37/39
• 危险类别码：
  R20/21/22,R36/37/38
• 海关编码：
  2931900090

反应信息

• 作为反应物：
  描述：

  氯甲基三甲基锡 在 KF 作用下， 以 二乙二醇二甲醚 为溶剂， 以32.6%的产率得到Fluormethyl-trimethyl-stannan
  参考文献：
  名称：

  Khrapov, V. V.; Goldanskii, V. I.; Prokofev, A. K., Zhurnal Obshchei Khimii, 1967, vol. 37, p. 1 - 7

  摘要：

  DOI：
• 作为产物：
  描述：

  trichloromethyl-trimethyl tin 在 三正丁基氢锡 作用下， 以 乙醚 为溶剂， 以8%的产率得到氯甲基三甲基锡
  参考文献：
  名称：

  有机金属反应。第十六部分。三卤代甲基锡化合物：其制备，性质和反应

  摘要：

  三烷基（二乙基氨基）锡化合物容易与卤代形式反应，生成相应的三烷基（三卤代甲基）锡，R 3 Sn·CX 3；这些然后可以通过三烷基锡氢化物，或通过氢化铝锂进行还原，得到二-和单- halogenomethyltin化合物中，R 3的Sn·CHX 2和R 3的Sn·CH 2 X，分别。已经研究了这些产物的一些性质和反应。

  DOI：

  10.1039/j39690001896

文献信息

• [EN] AZA PYRIDONE ANALOGS USEFUL AS MELANIN CONCENTRATING HORMONE RECEPTOR-1 ANTAGONISTS<br/>[FR] ANALOGUES D'AZAPYRIDONE UTILES COMME ANTAGONISTES DU RÉCEPTEUR 1 DE L'HORMONE CONCENTRANT LA MÉLANINE
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2010104818A1

  公开（公告）日：2010-09-16

  MCHR1 antagonists are provided having the following Formula (I): A1 and A2 are independently C or N; E is C or N; Q1, Q2, and Q3 are independently C or N provided that at least one of Q1, Q2, and Q3 is N but not more than one of Q1, Q2, and Q3 is N; D1 is a bond, -CR8R9 X-, -XCR8R9-, -CHR8CHR9-, -CR10=CR10'-, -C≡C-, or 1,2-cyclopropyl; X is O, S or NR11; R1, R2, and R3 are independently selected from the group consisting of hydrogen, halogen, lower alkyl, lower cycloalkyl, -CF3, -OCF3, -OR12 and -SR12; G is O, S or -NR15; D2 is lower alkyl, lower cycloalkyl, lower alkylcycloalkyl, lower cycloalkylalkyl, lower cycloalkoxyalkyl or lower alkylcycloalkoxy or when G is NR15, G and D2 together may optionally form an azetidine, pyrrolidine or piperidine ring; Z1 and Z2 are independently hydrogen, lower alkyl, lower cycloalkyl, lower alkoxy, lower cycloalkoxy, halo, -CF3, -OCONR14R14', -CN, -CONR14R14', -SOR12, -SO2R12, -NR14COR14', -NR14CO2R14', -CO2R12, NR14SO2R12 or COR12; R5, R6, and R7 are independently selected from the group consisting of hydrogen lower alkyl, lower cycloalkyl, -CF3, -SR12, lower alkoxy, lower cycloalkoxy, -CN, -CONR14R14', SOR12, SO2R12, NR14COR14', NR14CO2R12, CO2R12, NR14SO2R12 and -COR12; R8, R9, R10, R10', R11 are independently hydrogen or lower alkyl; R12 is lower alkyl or lower cycloalkyl; R14 and R14' are independently H, lower alkyl, lower cycloalkyl or R14 and R14' together with the N to which they are attached form a ring having 4 to 7 atoms; and R15 is independently selected from the group consisting of hydrogen and lower alkyl. Such compounds are useful for the treatment of MCHR1 mediated diseases, such as obesity, diabetes, IBD, depression, and anxiety.

  MCHR1拮抗剂具有以下化学式（I）：A1和A2独立地为C或N；E为C或N；Q1、Q2和Q3独立地为C或N，但至少其中一个为N，但不超过一个为N；D1为键，-CR8R9 X-，-XCR8R9-，-CHR8CHR9-，-CR10=CR10'-，-C≡C-，或1,2-环丙基；X为O、S或NR11；R1、R2和R3独立地从氢、卤素、低烷基、低环烷基、-CF3、-OCF3、-OR12和-SR12组成的群体中选择；G为O、S或-NR15；D2为低烷基、低环烷基、低烷基环烷基、低环烷基烷基、低环烷氧基烷基或低烷基环烷氧基，或当G为NR15时，G和D2一起可以选择形成氮杂环丙烷、吡咯烷或哌啶环；Z1和Z2独立地为氢、低烷基、低环烷基、低烷氧基、低环烷氧基、卤素、-CF3、-OCONR14R14'、-CN、-CONR14R14'、-SOR12、-SO2R12、-NR14COR14'、-NR14CO2R14'、-CO2R12、NR14SO2R12或COR12；R5、R6和R7独立地从氢、低烷基、低环烷基、-CF3、-SR12、低烷氧基、低环烷氧基、-CN、-CONR14R14'、SOR12、SO2R12、NR14COR14'、NR14CO2R12、CO2R12、NR14SO2R12和-COR12组成的群体中选择；R8、R9、R10、R10'、R11独立地为氢或低烷基；R12为低烷基或低环烷基；R14和R14'独立地为H、低烷基、低环烷基或R14和R14'与其连接的N一起形成具有4至7个原子的环；R15独立地从氢和低烷基组成的群体中选择。这些化合物对于治疗MCHR1介导的疾病，如肥胖症、糖尿病、炎症性肠病、抑郁症和焦虑症非常有用。
• Some group IVB derivatives of 1,6-methano[10]annulene. Synthesis, substituent effects and reactivity
  作者：William Kitching、Henry A. Olszowy、Inge Schott、William Adcock、D.P. Cox

  DOI：10.1016/0022-328x(86)80191-7

  日期：1986.8

  measure of the substituent effects exerted by metalloid-containing groups in this non-benzenoid aromatic system. Comparisons are made with the corresponding naphthalene and some anthracene derivatives. Protiodemetallations of a number of arylsilanes and -stannanes have been examined, and in protiodestannylation by CH3CO2H/dioxane at 27°C (an electrophilic aromatic substitution) the α- (or 2-) position of

  合成了1,6-甲基[10]环戊烯的某些IVB族衍生物，并记录和分配了它们的13 C核磁共振波谱，以测量这种非苯甲酸酯芳族化合物中含准金属的基团所产生的取代基作用。系统。与相应的萘和一些蒽衍生物进行了比较。已经研究了许多芳基硅烷和-锡烷基的金属丙酸酯化，并在27°C（亲电子芳族取代）下通过CH 3 CO 2 H /二恶烷进行金属甲酸酯化，在1,6-甲氧基的α-（或2-）位[ 10]环戊烯是约。反应活性是萘的α（或1-）位置的35倍，而在CF 3 CO 2 H / CH的丙硅烷基化中在27°C下3 CO 2 H约为。反应性高700倍。
• Group IVB metalloidal substituent effects by fluorine-19 resonance
  作者：Alan J. Smith、William Adcock、William Kitching

  DOI：10.1021/ja00724a007

  日期：1970.10

  Possible effects of substituents of the MR type (M = a group IVB metalloid, R = CH or CH) attached to an aryl system are evaluated and tested by examination of F substituent chemical shifts (SCS) of appropriate m- and p-fluorophenyl and 4,4′-fluorobiphenyl systems. (The extent to which a substituent electronically perturbs the C–F neighborhood is indicated by the substituent chemical shift (SCS), which

  通过检查适当的间氟苯基和对氟苯基的 F 取代基化学位移 (SCS) 来评估和测试连接到芳基系统的 MR 型取代基（M = IVB 族准金属，R = CH 或 CH）的可能影响。 4,4'-氟联苯系统。（取代基对 C-F 邻域的电子干扰程度由取代基化学位移 (SCS) 表示，其定义为未取代的氟代芳烃和取代的氟代芳烃化学位移之间的差异。）（CH）Si取代基参与对氟苯基三甲基硅烷和 4-氟-4'-三甲基甲硅烷基联苯的共轭电子撤回，而 (CH)Ge 基团在 4-氟-4'-三甲基锗基联苯中产生净电子撤回。全面的，证据表明所有 M(CH) 取代基都参与了 dπ-pπ 电子撤回，但这可能被屏蔽机制掩盖了。M(CH) 中的 CH 被苯基和乙烯基等电负性基团取代会导致更负的 SCS 值，因为准金属中心的有效电负性增加。还与五氟苯基系统的结果进行了比较。CHMR 类型的取代基（如上的 M 和 R）在对氟时产生大的正
• Halomethyl—metal compounds L. Preparation of monohalomethyl derivatives of germanium, tin, lead and mercury via halomethylzinc halides
  作者：Dietmar Seyferth、S. Brian Andrews

  DOI：10.1016/s0022-328x(00)90195-5

  日期：1971.7

  of iodomethylzinc iodide with trimethylchlorogermane gave in low yield both Me3GeCH2I and Me3GeCH2GeMe3. These compounds were obtained in much better yield when ICH2ZnI was allowed to react with germanium tetrachloride and the reaction product was methylated with MeMgBr. The reaction of iodomethyl-tin compounds with silver chloride and bromine in acetonitrile served well in the preparation of Me3SnCH2Cl

  Me 3 SnCH 2 I，Me 3 SnCH 2 Br，Me 2 Sn（CH 2 I）2，Me 2 Sn（ CH 2 Br）2，Me 2 PhSnCH 2 I，Ph 3 SnCH 2 I，Sn（CH 2 I）4，Ph 3 PbCH 2 I，Hg（CH 2 I）2和Hg（CH 2 Br）2。在大多数情况下，产品的产量非常好。碘代碘化锌锌与三甲基氯锗烷的反应均产生了低收率的Me 3 GeCH 2 I和Me 3 GeCH 2 GeMe 3。当使ICH 2 ZnI与四氯化锗反应并将反应产物用MeMgBr甲基化时，这些化合物的收率要好得多。碘甲基锡化合物与氯化银和溴在乙腈中的反应对于制备Me 3 SnCH 2 Cl，Me 3 SnCH 2 Br，Me 2 Sn（CH 2 Cl）2，Me2 Sn（CH 2 Br）2和Me 2 PhSnCH 2 Cl。
• TIN DODECAMERS AND RADIATION PATTERNABLE COATINGS WITH STRONG EUV ABSORPTION
  申请人：Inpria Corporation

  公开号：US20190308998A1

  公开（公告）日：2019-10-10

  Patterning compositions are described based on organo tin dodecamers with hydrocarbyl ligands, oxo ligands, hydroxo ligands and carboxylato ligands. Alternative dodecamer embodiments have organo tin ligands in place of hydrocarbyl ligands. The organo tin ligands can be incorporated into the dodecamers from a monomer with the structure (RCC) 3 SnQ, where R is a hydrocarbyl group and Q is a alkyl tin moiety with a carbon bonded to the Sn atom of the monomer and with a Sn bonded as a replacement of a quaternary carbon atom with bonds to 4 carbon atoms. Some or all of the carboxylato and hydroxyl ligands can be replaced with fluoride ions. Good EUV patterning results are obtained with the dodecamer based patterning compositions.

  基于具有烃基配体、氧配体、羟基配体和羧酸盐配体的有机锡十二聚体的图案化组合物被描述。替代的十二聚体实体具有代替烃基配体的有机锡配体。有机锡配体可以从具有结构（RCC）3SnQ的单体中并入十二聚体中，其中R是烃基团，Q是与单体的Sn原子连接的烷基锡基团，具有将Sn键合为代替四价碳原子并与4个碳原子键合的位置。一些或所有的羧酸盐和羟基配体可以被氟离子取代。基于十二聚体的图案化组合物获得良好的EUV图案化结果。