2-azido-4-p-tolyl-thiazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-azido-4-p-tolyl-thiazole
• 英文别名: 4--2-azido-thiazol；2-Azido-4-(4-methylphenyl)-1,3-thiazole；2-azido-4-(4-methylphenyl)-1,3-thiazole
• 化学式: C₁₀H₈N₄S
• 分子量: 216.266
• InChiKey: AYVMZPCKJNSYNB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  55.5
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-azido-4-p-tolyl-thiazole 、 乙酰乙酸乙酯 在 sodium methylate 、 水 、 sodium hydroxide 、 盐酸 作用下， 以 甲醇 、 水 为溶剂， 反应 1.0h， 以82%的产率得到5-methyl-1-[4-(4-methylphenyl)-1,3-thiazol-2-yl]-1H-1,2,3-triazole-4-carboxylic acid
  参考文献：
  名称：

  Synthesis of 2-Azido-1,3-thiazoles as 1,2,3-Triazole Precursors

  摘要：

  By diazotization of 2-aminothiazoles and reaction with sodium azide, the derivatives of 2-azidothiazole were synthesized. Conditions of diazotization were selected according to the nature of a substituent in thiazoles. 2-Azidothiazole derivatives were studied in the base-catalysed condensation reactions with activated methylenic compounds to yield new 1-(1,3-thiazol-2-yl)-1H-1,2,3-triazole-4-carboxylic acids.

  DOI：

  10.1080/00397910902981274
• 作为产物：
  描述：

  2-氨基-4-(对甲苯基)噻唑 在 磷酸 、 硝酸 、 sodium nitrite 、 sodium azide 作用下， 以 水 为溶剂， 以29%的产率得到2-azido-4-p-tolyl-thiazole
  参考文献：
  名称：

  Synthesis of 2-Azido-1,3-thiazoles as 1,2,3-Triazole Precursors

  摘要：

  By diazotization of 2-aminothiazoles and reaction with sodium azide, the derivatives of 2-azidothiazole were synthesized. Conditions of diazotization were selected according to the nature of a substituent in thiazoles. 2-Azidothiazole derivatives were studied in the base-catalysed condensation reactions with activated methylenic compounds to yield new 1-(1,3-thiazol-2-yl)-1H-1,2,3-triazole-4-carboxylic acids.

  DOI：

  10.1080/00397910902981274

文献信息

• Synthesis of 2-Azido-1,3-thiazoles as 1,2,3-Triazole Precursors
  作者：Nazariy T. Pokhodylo、Roman D. Savka、Nazar I. Pidlypnyi、Vasyl S. Matiychuk、Mykola D. Obushak

  DOI：10.1080/00397910902981274

  日期：2010.1.14

  By diazotization of 2-aminothiazoles and reaction with sodium azide, the derivatives of 2-azidothiazole were synthesized. Conditions of diazotization were selected according to the nature of a substituent in thiazoles. 2-Azidothiazole derivatives were studied in the base-catalysed condensation reactions with activated methylenic compounds to yield new 1-(1,3-thiazol-2-yl)-1H-1,2,3-triazole-4-carboxylic acids.