2-[[4,5-dimethyl-1-(p-tolylamino)-1H-imidazol-2-yl]thio]-1-(4-fluorophenyl)ethanone

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-[[4,5-dimethyl-1-(p-tolylamino)-1H-imidazol-2-yl]thio]-1-(4-fluorophenyl)ethanone
• 英文别名: 2-[4,5-Dimethyl-1-(4-methylanilino)imidazol-2-yl]sulfanyl-1-(4-fluorophenyl)ethanone；2-[4,5-dimethyl-1-(4-methylanilino)imidazol-2-yl]sulfanyl-1-(4-fluorophenyl)ethanone
• 化学式: C₂₀H₂₀FN₃OS
• 分子量: 369.463
• InChiKey: AZAFSVDIOQJUMW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  72.2
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  对甲基苯肼 在 potassium carbonate 、 溶剂黄146 作用下， 以 丙酮 为溶剂， 生成 2-[[4,5-dimethyl-1-(p-tolylamino)-1H-imidazol-2-yl]thio]-1-(4-fluorophenyl)ethanone
  参考文献：
  名称：

  Synthesis and initial biological evaluation of substituted 1-phenylamino-2-thio-4,5-dimethyl-1H-imidazole derivatives

  摘要：

  In this work, some new 2-[(4,5-dimethyl-1-(arylamino)-1H-imidazol-2-yl)thio]-1-(aryl) ethanone derivatives were synthesized and investigated for their antibacterial, antifungal and anticancer activities. Toxicity of the most effective compounds was established by performing Brine-Shrimp lethality assay. Antifungal activity of the compounds was found to be higher than antibacterial and anticancer activities of the compounds. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2013.10.024

文献信息

• Synthesis and initial biological evaluation of substituted 1-phenylamino-2-thio-4,5-dimethyl-1H-imidazole derivatives
  作者：Leyla Yurttaş、Murat Duran、Şeref Demirayak、Hülya Karaca Gençer、Yağmur Tunalı

  DOI：10.1016/j.bmcl.2013.10.024

  日期：2013.12

  In this work, some new 2-[(4,5-dimethyl-1-(arylamino)-1H-imidazol-2-yl)thio]-1-(aryl) ethanone derivatives were synthesized and investigated for their antibacterial, antifungal and anticancer activities. Toxicity of the most effective compounds was established by performing Brine-Shrimp lethality assay. Antifungal activity of the compounds was found to be higher than antibacterial and anticancer activities of the compounds. (C) 2013 Elsevier Ltd. All rights reserved.