(3-fluorophenyl)(quinolin-3-yl)methanone

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (3-fluorophenyl)(quinolin-3-yl)methanone
• 英文别名: (3-fluorophenyl)-quinolin-3-ylmethanone
• 化学式: C₁₆H₁₀FNO
• 分子量: 251.26
• InChiKey: AZQHACLDMUVDTR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  30
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  苯甲醯亞胺酸 、 二甲基亚砜 、 3'-氟苯乙酮 在 Selectfluor 作用下， 反应 24.0h， 以58%的产率得到(3-fluorophenyl)(quinolin-3-yl)methanone
  参考文献：
  名称：

  通过 Selectfluor 介导的 C(sp3)-H 键活化从苯乙酮和蒽醌高效合成 3-酰基喹啉†

  摘要：

  已经描述了一种从市售苯乙酮和蒽醌合成 3-官能化喹啉的有效方法。Selectfluor 推动苯乙酮的 C(sp 3 )-H 键活化和邻氨基苯甲酸酯的 aza-Michael 加成，从而以中等至高产率产生环状 3-酰基喹啉。DMSO 不仅充当溶剂，而且在反应中充当单碳供体。

  DOI：

  10.1039/c9ra01481k

文献信息

• Trisubstitutedsilylphenoxyheterocycles and analogues
  申请人：Bayer CropScience Aktiengesellschaft

  公开号：US10683311B2

  公开（公告）日：2020-06-16

  The present disclosure relates to fungicidal active compounds, more specifically to trisubstitutedsilylphenoxyhetero-cycles and analogues thereof, processes and, intermediates for their preparation and use thereof as fungicidal active compound, particularly in the form of fungicide compositions. The present disclosure also relates to methods for the control of phytopathogenic fungi of plants using these compounds or compositions comprising thereof.

  本公开涉及杀真菌活性化合物，更具体地说，涉及三取代硅基苯氧基杂环及其类似物、制备它们的工艺和中间体以及它们作为杀真菌活性化合物的用途，特别是以杀真菌剂组合物的形式。本公开还涉及使用这些化合物或包含这些化合物的组合物控制植物的植物病原真菌的方法。
• TRISUBSTITUTED SILYLPHENOXYHETEROCYCLES AND ANALOGUES
  申请人：Bayer CropScience Aktiengesellschaft

  公开号：EP3368514B1

  公开（公告）日：2021-08-18
• TRISUBSTITUTEDSILYLPHENOXYHETEROCYCLES AND ANALOGUES
  申请人：Bayer CropScience Aktiengesellschaft

  公开号：US20190233444A1

  公开（公告）日：2019-08-01

  The present disclosure relates to fungicidal active compounds, more specifically to trisubstitutedsilylphenoxyhetero-cycles and analogues thereof, processes and, intermediates for their preparation and use thereof as fungicidal active compound, particularly in the form of fungicide compositions. The present disclosure also relates to methods for the control of phytopathogenic fungi of plants using these compounds or compositions comprising thereof.
• [EN] TRISUBSTITUTEDSILYLPHENOXYHETEROCYCLES AND ANALOGUES<br/>[FR] HÉTÉROCYCLES SILYLPHÉNOXY TRISUBSTITUÉS ET ANALOGUES
  申请人：BAYER CROPSCIENCE AG

  公开号：WO2017072283A1

  公开（公告）日：2017-05-04

  The present disclosure relates to fungicidal active compounds, more specifically to trisubstitutedsilylphenoxyheterocycles and analogues thereof, processes and, intermediates for their preparation and use thereof as fungicidal active compound, particularly in the form of fungicide compositions. The present disclosure also relates to methods for the control of phytopathogenic fungi of plants using these compounds or compositions comprising thereof.
• An efficient 3-acylquinoline synthesis from acetophenones and anthranil<i>via</i>C(sp³)–H bond activation mediated by Selectfluor
  作者：Yejun Gao、Robert C. Hider、Yongmin Ma

  DOI：10.1039/c9ra01481k

  日期：——

  method for the synthesis of 3-functionalized quinolines from commercially available acetophenones and anthranil has been described. Selectfluor propels the C(sp3)–H bond activation of the acetophenones and aza-Michael addition of anthranil resulting in annulated 3-acylquinolines in moderate to high yields. DMSO acts not only as a solvent but also as a one carbon donor in the reaction.

  已经描述了一种从市售苯乙酮和蒽醌合成 3-官能化喹啉的有效方法。Selectfluor 推动苯乙酮的 C(sp 3 )-H 键活化和邻氨基苯甲酸酯的 aza-Michael 加成，从而以中等至高产率产生环状 3-酰基喹啉。DMSO 不仅充当溶剂，而且在反应中充当单碳供体。