6-Chloro-7-(4-chloro-phenylamino)-2,3-di-pyridin-2-yl-quinoxaline-5,8-dione

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 6-Chloro-7-(4-chloro-phenylamino)-2,3-di-pyridin-2-yl-quinoxaline-5,8-dione
• 英文别名: 6-Chloro-7-(4-chloroanilino)-2,3-dipyridin-2-ylquinoxaline-5,8-dione
• 化学式: C₂₄H₁₃Cl₂N₅O₂
• 分子量: 474.306
• InChiKey: BCHZLOBLFNAZSN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  33
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  97.7
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  二(2-吡啶基)乙二酮 在 盐酸 、 硝酸 作用下， 以 乙醇 、 水 为溶剂， 反应 6.0h， 生成 6-Chloro-7-(4-chloro-phenylamino)-2,3-di-pyridin-2-yl-quinoxaline-5,8-dione
  参考文献：
  名称：

  Synthesis and biological evaluation of quinoxaline-5,8-diones that inhibit vascular smooth muscle cell proliferation

  摘要：

  A series of 6-arylamino-2,3-bis(pyridin-2-yl)-7-chloro-quinoxaline-5,8-diones were synthesized and evaluated for their inhibitory activity on rat aortic smooth muscle cell (RAoSMC) proliferation. The quinoxaline-5,8-diones exhibited a potent antiproliferative activity. Further mechanistic study revealed that the inhibitory effect of one representative quinoxaline-5,8-dione on SMC proliferation was mediated by modulation of the extracellular signal-regulated kinase 1/2 signaling pathway in the RAoSMCs. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.05.022

文献信息

• Synthesis and biological evaluation of quinoxaline-5,8-diones that inhibit vascular smooth muscle cell proliferation
  作者：Hwa-Jin Chung、Ok-Jai Jung、Mi Jin Chae、Sung-Yu Hong、Kwang-Hoe Chung、Sang Kook Lee、Chung-Kyu Ryu

  DOI：10.1016/j.bmcl.2005.05.022

  日期：2005.7

  A series of 6-arylamino-2,3-bis(pyridin-2-yl)-7-chloro-quinoxaline-5,8-diones were synthesized and evaluated for their inhibitory activity on rat aortic smooth muscle cell (RAoSMC) proliferation. The quinoxaline-5,8-diones exhibited a potent antiproliferative activity. Further mechanistic study revealed that the inhibitory effect of one representative quinoxaline-5,8-dione on SMC proliferation was mediated by modulation of the extracellular signal-regulated kinase 1/2 signaling pathway in the RAoSMCs. (c) 2005 Elsevier Ltd. All rights reserved.