daphnicyclidin G

• 分子结构分类: 有机化合物 - 碳氢化合物 - 不饱和烃
• 英文名称: daphnicyclidin G
• 英文别名: (2S,3R,5S,6R,10S)-5-hydroxy-2,6-dimethyl-14-oxa-8-azahexacyclo[11.6.1.15,19.02,10.03,8.017,20]henicosa-1(19),13(20),17-trien-21-one
• 化学式: C₂₁H₂₅NO₃
• 分子量: 339.434
• InChiKey: BJHCYYSZMWMXBE-JYYDYUEOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  25
• 可旋转键数：
  0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  49.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  达菲环素D 在 氢氧化钾 、 碘苯二乙酸 、 对甲苯磺酸 作用下， 以 水 、 苯 为溶剂， 反应 96.0h， 生成 daphnicyclidin G
  参考文献：
  名称：

  Daphnicyclidins A−H, Novel Hexa- or Pentacyclic Alkaloids from Two Species of Daphniphyllum

  摘要：

  Eight highly modified Daphniphyllum alkaloids with unprecedented fused hexa- or pentacyclic skeletons, daphnicyclidins A-H (1-8), have been isolated from the stems of Daphniphyllum humile and D. teijsmanni, and their structures were elucidated on the basis of spectroscopic data and chemical means. The stereochemistry was elucidated by combination of NOESY correlations, X-ray crystallographic data, and CD analyses.

  DOI：

  10.1021/ja016955e

文献信息

• Daphnicyclidins A−H, Novel Hexa- or Pentacyclic Alkaloids from Two Species of <i>Daphniphyllum</i>
  作者：Jun'ichi Kobayashi、Yasutada Inaba、Motoo Shiro、Naotoshi Yoshida、Hiroshi Morita

  DOI：10.1021/ja016955e

  日期：2001.11.1

  Eight highly modified Daphniphyllum alkaloids with unprecedented fused hexa- or pentacyclic skeletons, daphnicyclidins A-H (1-8), have been isolated from the stems of Daphniphyllum humile and D. teijsmanni, and their structures were elucidated on the basis of spectroscopic data and chemical means. The stereochemistry was elucidated by combination of NOESY correlations, X-ray crystallographic data, and CD analyses.