乙基 2,3,4,6-O-四乙酰基-ALPHA-D-硫代吡喃葡萄糖苷 | 52645-73-5

• 物质功能分类: 生物化工 - 糖类化合物 - 单糖
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 乙基 2,3,4,6-O-四乙酰基-ALPHA-D-硫代吡喃葡萄糖苷
• 中文别名: 乙基2,3,4,6-O-四乙酰基-ALPHA-D-硫代吡喃葡萄糖苷；乙基2,3,4,6-O-四乙酰基-alpha-D-硫代吡喃葡萄糖苷；乙基-2,3,4,6-四-O-乙酰基-Α-D-硫代吡喃葡萄糖苷
• 英文名称: (3,4,5-Triacetyloxy-6-ethylsulfanyl-oxan-2-yl)methyl ethanoate
• 英文别名: (3,4,5-triacetyloxy-6-ethylsulfanyloxan-2-yl)methyl acetate
• CAS: 52645-73-5
• 化学式: C₁₆H₂₄O₉S
• 分子量: 392.4
• InChiKey: YPNFVZQPWZMHIF-UHFFFAOYSA-N

物化性质

• 熔点：
  78-79 °C
• 沸点：
  453.2±45.0 °C(Predicted)
• 密度：
  1.27±0.1 g/cm3(Predicted)
• 溶解度：
  可溶于氯仿、乙酸乙酯

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  26
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  140
• 氢给体数：
  0
• 氢受体数：
  10

安全信息

• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335
• 储存条件：
  2-8℃，干燥，密封

文献信息

• Synthetic Method of 20 (S)-Ginsenoside Rh2
  申请人：Hui Yongzheng

  公开号：US20080275225A1

  公开（公告）日：2008-11-06

  A synthetic method of 20(s)-ginsenoside Rh2, that is 20(S)-protopanaxdiol-3-O-β-D-glucopyranoside, is comprised of: protecting protopanaxdiol (A1) selectively first to produce monosubstituted protopanaxdiol (A2); and Glycosidating the monosubstituted protopanaxdiol with Glucopyranosyl donor in the presence of Lewis acid catalyst; Deprotecting the product; Then separating and purifying to obtain 20(s)-ginsenoside Rh2. The method is conducted under mild condition at low cost, and affords product with high stereoselectivity, high yield and purity. Therefore, the synthetic method of the present invention is suitable for production on large scale.

  一种20（s）-人参皂苷Rh2的合成方法，即20（S）-原人参二醇-3-O-β-D-葡萄糖苷，包括：首先选择性地保护原人参二醇（A1）以生成单取代原人参二醇（A2）；然后在Lewis酸催化剂存在下将单取代原人参二醇与葡萄糖吡喃基供体进行糖苷化反应；脱保护产物；然后分离纯化以获得20（s）-人参皂苷Rh2。该方法在温和条件下，成本低廉，并且产物具有高立体选择性、高产率和纯度。因此，本发明的合成方法适用于大规模生产。
• Glycomimetic inhibitors of the PA-IL lectin, PA-IIL lectin or both the lectins from pseudomonas
  申请人：Magnani L. John

  公开号：US20070037775A1

  公开（公告）日：2007-02-15

  Compositions and methods are provided related to Pseudomonas bacteria. The compositions and methods may be used for diagnosis and therapy of medical conditions involving infection with Pseudomonas bacteria. Such infections include Pseudomonas aeruginosa in the lungs of patients with cystic fibrosis. A compound useful in the present methods may be used in combination with a therapeutic agent or may be linked to a therapeutic agent. Pseudomonas bacteria may be inhibited by blocking colonization, inhibiting virulence factors, arresting growth or killing the bacteria.

  提供与铜绿假单胞菌相关的组合物和方法。这些组合物和方法可用于诊断和治疗涉及铜绿假单胞菌感染的医疗状况。这些感染包括囊性纤维化患者肺部中的铜绿假单胞菌。在目前的方法中有用的化合物可以与治疗剂结合使用，或者可以与治疗剂连接。通过阻止定植、抑制毒力因子、阻止生长或杀死细菌可以抑制铜绿假单胞菌。
• GLYCOMIMETIC INHIBITORS OF THE PA-IL LECTIN, PA-IIL LECTIN OR BOTH THE LECTINS FROM PSEUDOMONAS
  申请人：Magnani John L.

  公开号：US20100041626A1

  公开（公告）日：2010-02-18

  Compositions and methods are provided related to Pseudomonas bacteria. The compositions and methods may be used for diagnosis and therapy of medical conditions involving infection with Pseudomonas bacteria. Such infections include Pseudomonas aeruginosa in the lungs of patients with cystic fibrosis. A compound useful in the present methods may be used in combination with a therapeutic agent or may be linked to a therapeutic agent. Pseudomonas bacteria may be inhibited by blocking colonization, inhibiting virulence factors, arresting growth or killing the bacteria.
• Radiohaloimatinibs and Methods of Their Synthesis and Use in PET Imaging of Cancers
  申请人：Bornmann William

  公开号：US20100322858A1

  公开（公告）日：2010-12-23

  We disclose methods of synthesizing radiohalidated organic compounds and their use in positron emission tomography (PET) imaging of cancer cells.
• US7517980B2
  申请人：——

  公开号：US7517980B2

  公开（公告）日：2009-04-14