HI-321

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: HI-321
• 英文别名: N-[(2R)-4-chloro-3-oxo-1-undecylsulfanylbutan-2-yl]acetamide
• 化学式: C₁₇H₃₂ClNO₂S
• 分子量: 349.966
• InChiKey: LCRQNDYIWWPBKI-INIZCTEOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  22
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  71.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N-乙酰-L-半胱氨酸 在 N-甲基吗啉 、 盐酸 、 氨 作用下， 以 四氢呋喃 、 甲醇 、 乙醚 、 乙酸乙酯 为溶剂， 生成 HI-321
  参考文献：
  名称：

  The S -alkyl chain length as a determinant of the anti-leukemic activity of cysteine chloromethyl ketone compounds

  摘要：

  A series of cysteine chloromethyl ketone compounds with a systematic variation of the S-alkyl chain length have been synthesized in order to gauge the effect of the alkyl chain length on the cytotoxicity of these compounds against human acute lymphoblastic leukemia cells. Comparable activities were observed for compounds with S-alkyl chains ranging from pentyl to dodecyl, with the best being undecyl (IC50 = 1.7 mu M) and dodecyl (IC50 = 2.0 mu M) against B-lineage leukemia cells and hexyl (IC50 = 0.7 mu M) against T-lineage leukemia cells. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00047-0

文献信息

• The S -alkyl chain length as a determinant of the anti-leukemic activity of cysteine chloromethyl ketone compounds
  作者：David A Perrey、Michael P Scannell、Rama Krishna Narla、Fatih M Uckun

  DOI：10.1016/s0960-894x(00)00047-0

  日期：2000.3

  A series of cysteine chloromethyl ketone compounds with a systematic variation of the S-alkyl chain length have been synthesized in order to gauge the effect of the alkyl chain length on the cytotoxicity of these compounds against human acute lymphoblastic leukemia cells. Comparable activities were observed for compounds with S-alkyl chains ranging from pentyl to dodecyl, with the best being undecyl (IC50 = 1.7 mu M) and dodecyl (IC50 = 2.0 mu M) against B-lineage leukemia cells and hexyl (IC50 = 0.7 mu M) against T-lineage leukemia cells. (C) 2000 Elsevier Science Ltd. All rights reserved.