2-fluoro-6-O-(4-nitrophenylethyl)-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-2'-deoxyinosine

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: 2-fluoro-6-O-(4-nitrophenylethyl)-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-2'-deoxyinosine
• 英文别名: 9-[(6aR,8R,9aS)-2,2,4,4-tetra(propan-2-yl)-6a,8,9,9a-tetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl]-2-fluoro-6-[2-(4-nitrophenyl)ethoxy]purine
• 化学式: C₃₀H₄₄FN₅O₇Si₂
• 分子量: 661.878
• InChiKey: XTUPLTILXXGDNG-JIMJEQGWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.74
• 重原子数：
  45
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.63
• 拓扑面积：
  136
• 氢给体数：
  0
• 氢受体数：
  11

反应信息

• 作为产物：
  描述：

  6-O-(4-nitrophenylethyl)-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-2'-deoxyguanosine 在 亚硝酸特丁酯 作用下， 以 甲苯 为溶剂， 生成 2-fluoro-6-O-(4-nitrophenylethyl)-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-2'-deoxyinosine
  参考文献：
  名称：

  Synthetic Oligonucleotide Combinatorial Libraries. 3. Synthesis of Polyamevonucleosides

  摘要：

  Synthesis of polyamino-2'-deoxynucleosides was studied. A synthesis of 2'-deoxyadenosine and 2'-deoxyguanosine derivatives carrying a protected spermine moiety at N-6 and N-2 positions respectively is described using unprotected polyamines as substrates. The question of reactivity of primary and secondary amino groups present in polyamines was studied. The evidence that only primary amino groups react with the synthesised precursors was accomplished from experiments with a secondary amine (di-n-butylamine). An approach to analyse properties of polyaminooligonucleotides using their synthetic combinatorial libraries is discussed.

  DOI：

  10.1080/07328319908044615

文献信息

• Synthetic Oligonucleotide Combinatorial Libraries. 3. Synthesis of Polyamevonucleosides
  作者：Przemyslaw Godzina、Katarzyna Adrych-Rozek、Wojciech T. Markiewicz

  DOI：10.1080/07328319908044615

  日期：1999.11

  Synthesis of polyamino-2'-deoxynucleosides was studied. A synthesis of 2'-deoxyadenosine and 2'-deoxyguanosine derivatives carrying a protected spermine moiety at N-6 and N-2 positions respectively is described using unprotected polyamines as substrates. The question of reactivity of primary and secondary amino groups present in polyamines was studied. The evidence that only primary amino groups react with the synthesised precursors was accomplished from experiments with a secondary amine (di-n-butylamine). An approach to analyse properties of polyaminooligonucleotides using their synthetic combinatorial libraries is discussed.