2-(3,4-dichlorophenyl)quinoline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-(3,4-dichlorophenyl)quinoline
• 化学式: C₁₅H₉Cl₂N
• 分子量: 274.149
• InChiKey: UUEPGGCAFIRGRJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-(3,4-二氯苯基)-喹啉-4-羧酸 生成 2-(3,4-dichlorophenyl)quinoline
  参考文献：
  名称：

  The Pfitzinger Reaction in the Synthesis of Quinoline Derivatives

  摘要：

  DOI：

  10.1021/jo50015a019

文献信息

• Ruthenium-catalyzed acceptorless dehydrogenative coupling of o-aminobenzyl alcohols with ketones to quinolines in the presence of carbonate salt
  作者：Xiangchao Xu、Yao Ai、Rongzhou Wang、Liping Liu、Jiazhi Yang、Feng Li

  DOI：10.1016/j.jcat.2020.12.016

  日期：2021.3

  Cl][Cl] was designed, synthesized and found to be a general and highly efficient catalyst for the synthesis of quinolines via acceptorless dehydrogenative coupling of o-aminobenzyl alcohols with ketones in the presence of carbonate salt. It was confirmed that NH units in the ligand are crucial for catalytic activity. The application of this catalytic system for the scale-gram synthesis of biologically

  设计，合成了带有功能性2,2'-联苯并咪唑配体[（p- Cymene）Ru（BiBzImH 2）Cl] [Cl]的钌配合物，它是通过无受体合成喹啉的通用高效催化剂。碳酸盐存在下邻氨基苄醇与酮的脱氢偶联。证实了配体中的NH单元对于催化活性至关重要。还进行了该催化体系在生物活性分子的规模克合成中的应用。值得注意的是，这项研究展示了金属-配体双功能催化剂在无受体脱氢反应中的新潜力。
• An efficient synthesis of quinolines via copper-catalyzed C–N cleavage
  作者：Long-Yi Xi、Ruo-Yi Zhang、Lei Zhang、Shan-Yong Chen、Xiao-Qi Yu

  DOI：10.1039/c5ob00075k

  日期：——

  An efficient method to synthesize substituted quinolines from ketones and 2-amino benzylamines is described.

  描述了一种从酮和2-氨基苄胺合成取代喹啉的高效方法。

• The preparation of a Co@C₃N₄ catalyst and applications in the synthesis of quinolines from 2-aminobenzyl alcohols with ketones
  作者：Fei Cao、Anruo Mao、Bobin Yang、Chenyang Ge、Dawei Wang

  DOI：10.1039/d0nj05767c

  日期：——

  recyclable catalyst, which could easily be reused. Therefore, a heterogeneous catalyst was synthesized through Co-doping of C3N4, and the Co-nanoparticles on C3N4 revealed high catalytic activity for the synthesis of quinolines with good recovery performance.

  合成了不对称的二苯基膦基吡啶基三唑配体，并通过红外，核磁共振和质谱对其进行了表征，并制备了相应的地球上富金属的金属配合物（钴）。考虑到能源消耗和环境友好性，有必要将这种二苯基膦基-吡啶基-三唑钴配合物转变为可循环使用的催化剂，以使其易于再利用。因此，非均相催化剂通过的C CO掺杂合成3 Ñ 4，和C上的钴纳米颗粒3 Ñ 4显示高的催化活性为具有良好的恢复性能喹啉的合成。
• Visible-Light-Mediated Oxidative Cyclization of 2-Aminobenzyl Alcohols and Secondary Alcohols Enabled by an Organic Photocatalyst
  作者：Jing-xiu Xu、Nan-lian Pan、Jia-xi Chen、Jin-wu Zhao

  DOI：10.1021/acs.joc.1c01386

  日期：2021.8.6

  This paper describes a visible-light-mediated oxidative cyclization of 2-aminobenzyl alcohols and secondary alcohols to produce quinolines at room temperature. This photocatalytic method employed anthraquinone as an organic small-molecule catalyst and DMSO as an oxidant. According to this present procedure, a series of quinolines were prepared in satisfactory yields.

  本文描述了 2-氨基苯甲醇和仲醇在室温下通过可见光介导的氧化环化生产喹啉的方法。该光催化方法采用蒽醌作为有机小分子催化剂，DMSO作为氧化剂。根据本程序，以令人满意的收率制备了一系列喹啉。
• N-type calcium channel antagonists for the treatment of pain
  申请人：D'Amico Derin

  公开号：US20050131020A1

  公开（公告）日：2005-06-16

  Compounds useful for the treatment of pain in accord with the following structural diagram, wherein A, R 1 , b, R 3 , d, R 4 , R 5 , R 6 and R 7 are any of a number of groups as defined in the specification, and pharmaceutical compositions and methods of treatment utilizing such compounds.

  以下化学结构图所示的化合物可用于治疗疼痛，其中A、R1、b、R3、d、R4、R5、R6和R7是规范中定义的许多基团中的任何一个，以及使用这些化合物的制药组合物和治疗方法。