(R)-3-hydroxyhexane-2,5-dione

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (R)-3-hydroxyhexane-2,5-dione
• 英文别名: (3R)-3-hydroxyhexane-2,5-dione
• 化学式: C₆H₁₀O₃
• 分子量: 130.144
• InChiKey: MXGSILCFPNVDMX-ZCFIWIBFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  丙酮 、 丙酮醛 在 C₃₂H₂₉N₃O₃S 作用下， 以 水 为溶剂， 反应 12.0h， 以94%的产率得到(R)-3-hydroxyhexane-2,5-dione
  参考文献：
  名称：

  Aqueous Enantioselective Aldol Reaction of Methyl- and Phenylglyoxal Organocatalyzed by N-Tosyl-(S a)-binam-l-prolinamide

  摘要：

  DOI：

  10.1055/s-0034-1379969

文献信息

• SYNTHETIC PROCESS FOR AMINOCYCLOHEXYL ETHER COMPOUNDS
  申请人：Cardiome Pharma Corp.

  公开号：US20150336887A1

  公开（公告）日：2015-11-26

  Methods for the preparation of stereoisomerically substantially aminocyclohexyl ether compounds such as trans-(1R,2R)-aminocyclohexyl ether compounds and/or trans-(1S,2S)-aminocyclohexyl ether compounds as well as various intermediates and substrates are disclosed.

  本发明公开了制备立体异构的氨基环己基醚化合物的方法，例如trans-(1R,2R)-氨基环己基醚化合物和/或trans-(1S,2S)-氨基环己基醚化合物，以及各种中间体和底物。
• NOVEL DICARBOXYLIC ACID LINKED AMINO ACID AND PEPTIDE PRODRUGS OF OPIOIDS AND USES THEREOF
  申请人：Franklin Richard

  公开号：US20100286186A1

  公开（公告）日：2010-11-11

  The present invention concerns dicarboxylic acid linked amino acid and peptide prodrugs of opioid analgesics and pharmaceutical compositions containing such prodrugs. Methods for providing pain relief, decreasing the adverse GI side effects of the opioid analgesic and increasing the bioavailability of the opioid analgesic with the aforementioned prodrugs are also provided. In one embodiment, prodrugs having the amino acid side chains of valine, leucine, isoleucine and glycine; and mono-, di- and tripeptides thereof are provided.
• Aqueous Enantioselective Aldol Reaction of Methyl- and Phenylglyoxal Organocatalyzed by N-Tosyl-(S a)-binam-l-prolinamide
  作者：Gabriela Guillena、Carmen Nájera、Fernando Moles

  DOI：10.1055/s-0034-1379969

  日期：——